Zobrazeno 1 - 10
of 3 928
pro vyhledávání: '"Natarajan V."'
Autor:
Priya Mittal, Jacquelyn A. Myers, Raymond D. Carter, Sandi Radko-Juettner, Hayden A. Malone, Wojciech Rosikiewicz, Alexis N. Robertson, Zhexin Zhu, Ishwarya V. Narayanan, Baranda S. Hansen, Meadow Parrish, Natarajan V. Bhanu, Robert J. Mobley, Jerold E. Rehg, Beisi Xu, Yiannis Drosos, Shondra M. Pruett-Miller, Mats Ljungman, Benjamin A. Garcia, Gang Wu, Janet F. Partridge, Charles W. M. Roberts
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are mutated in nearly 25% of cancers. To gain insight into the mechanisms by which SWI/SNF mutations drive cancer, we contributed ten rhabdoid tumor (RT) cell lines muta
Externí odkaz:
https://doaj.org/article/fb1fbd9e73e346ad922fc3783cc2f771
Autor:
Dennis Huang, Angeliki Mela, Natarajan V. Bhanu, Benjamin A. Garcia, Peter Canoll, Patrizia Casaccia
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101042- (2024)
Proneural gliomas are brain tumors characterized by enrichment of oligodendrocyte progenitor cell (OPC) transcripts and genetic alterations. In this study we sought to identify transcriptional and epigenetic differences between OPCs with Trp53 deleti
Externí odkaz:
https://doaj.org/article/6db1d6b7c3b943999a65b9f97ac8f027
Autor:
Lorna A. Farrelly, Shuangping Zheng, Nadine Schrode, Aaron Topol, Natarajan V. Bhanu, Ryan M. Bastle, Aarthi Ramakrishnan, Jennifer C Chan, Bulent Cetin, Erin Flaherty, Li Shen, Kelly Gleason, Carol A. Tamminga, Benjamin A. Garcia, Haitao Li, Kristen J. Brennand, Ian Maze
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Schizophrenia (SZ) is a severe psychiatric disorder; unfortunately, only ~1/3 of patients respond favorably to treatment. Here, the authors reveal hyperacetylation of histone H2A.Z in SZ neurons and postmortem SZ human brain tissues. They further sho
Externí odkaz:
https://doaj.org/article/82c68feb169f4133ac1edea10af43af7
Autor:
Jennifer C. Chan, Christopher P. Morgan, N. Adrian Leu, Amol Shetty, Yasmine M. Cisse, Bridget M. Nugent, Kathleen E. Morrison, Eldin Jašarević, Weiliang Huang, Nickole Kanyuch, Ali B. Rodgers, Natarajan V. Bhanu, Dara S. Berger, Benjamin A. Garcia, Seth Ament, Maureen Kane, C. Neill Epperson, Tracy L. Bale
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Evidence for sperm small noncoding RNA-mediated intergenerational transmission implies communication from responsive somatic cells to sperm. Here, authors show that epididymal cells alter extracellular vesicle cargo after stress exposure, to impact o
Externí odkaz:
https://doaj.org/article/25257cea7d2d42d8a29025504d0f0690
Autor:
Li Tan, Zhonghe Ke, Gregory Tombline, Nicholas Macoretta, Kevin Hayes, Xiao Tian, Ruitu Lv, Julia Ablaeva, Michael Gilbert, Natarajan V. Bhanu, Zuo-Fei Yuan, Benjamin A. Garcia, Yujiang G. Shi, Yang Shi, Andrei Seluanov, Vera Gorbunova
Publikováno v:
Stem Cell Reports, Vol 9, Iss 5, Pp 1721-1734 (2017)
Summary: Naked mole rat (NMR) is a valuable model for aging and cancer research due to its exceptional longevity and cancer resistance. We observed that the reprogramming efficiency of NMR fibroblasts in response to OSKM was drastically lower than th
Externí odkaz:
https://doaj.org/article/555f64213cd742b0b9d42f0735085c92
Autor:
Johayra Simithy, Simone Sidoli, Zuo-Fei Yuan, Mariel Coradin, Natarajan V. Bhanu, Dylan M. Marchione, Brianna J. Klein, Gleb A. Bazilevsky, Cheryl E. McCullough, Robert S. Magin, Tatiana G. Kutateladze, Nathaniel W. Snyder, Ronen Marmorstein, Benjamin A. Garcia
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
A number of histone lysine modifications related to acetylation have been identified, but their functional significance is unclear. Here, the authors use in vitro and in vivo assays to characterize eight acyl histone post-translational modifications
Externí odkaz:
https://doaj.org/article/d14a3bef3d85449ebebdccbdcf9b9c22
Autor:
Maithili P. Dalvi, Lei Wang, Rui Zhong, Rahul K. Kollipara, Hyunsil Park, Juan Bayo, Paul Yenerall, Yunyun Zhou, Brenda C. Timmons, Jaime Rodriguez-Canales, Carmen Behrens, Barbara Mino, Pamela Villalobos, Edwin R. Parra, Milind Suraokar, Apar Pataer, Stephen G. Swisher, Neda Kalhor, Natarajan V. Bhanu, Benjamin A. Garcia, John V. Heymach, Kevin Coombes, Yang Xie, Luc Girard, Adi F. Gazdar, Ralf Kittler, Ignacio I. Wistuba, John D. Minna, Elisabeth D. Martinez
Publikováno v:
Cell Reports, Vol 19, Iss 8, Pp 1669-1684 (2017)
Although non-small cell lung cancer (NSCLC) patients benefit from standard taxane-platin chemotherapy, many relapse, developing drug resistance. We established preclinical taxane-platin-chemoresistance models and identified a 35-gene resistance signa
Externí odkaz:
https://doaj.org/article/b799525f4c5f4794b566dfe7987f5ae9
Autor:
Vivek Behera, Aaron J. Stonestrom, Nicole Hamagami, Chris C. Hsiung, Cheryl A. Keller, Belinda Giardine, Simone Sidoli, Zuo-Fei Yuan, Natarajan V. Bhanu, Michael T. Werner, Hongxin Wang, Benjamin A. Garcia, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 400-415.e5 (2019)
Summary: Global changes in chromatin organization and the cessation of transcription during mitosis are thought to challenge the resumption of appropriate transcription patterns after mitosis. The acetyl-lysine binding protein BRD4 has been previousl
Externí odkaz:
https://doaj.org/article/8b145c50765d4778bd5ce4df11b251aa
Autor:
Huang, Dennis, Mela, Angeliki, Bhanu, Natarajan V., Garcia, Benjamin A., Canoll, Peter, Casaccia, Patrizia
Publikováno v:
In Neoplasia November 2024 57
Publikováno v:
In Ore and Energy Resource Geology October 2024 17