Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Natarajan Perumal"'
Autor:
Till Grandjean, Natarajan Perumal, Caroline Manicam, Björn Matthey, Tao Wu, Daniel G. E. Thiem, Stefan Stein, Dirk Henrich, Peer W. Kämmerer, Bilal Al-Nawas, Ulrike Ritz, Sebastian Blatt
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Introduction:Autologous platelet concentrate (APC) are pro-angiogenic and can promote wound healing and tissue repair, also in combination with other biomaterials. However, challenging defect situations remain demanding. 3D bioprinting of an APC base
Externí odkaz:
https://doaj.org/article/f94a2e03f41a4c73ad8bb71eefec4252
Publikováno v:
Cells, Vol 13, Iss 9, p 775 (2024)
Glaucoma is a heterogeneous group of optic neuropathies characterized by a progressive degeneration of the retinal ganglion cells (RGCs), leading to irreversible vision loss. Nowadays, the traditional therapeutic approach to glaucoma consists of lowe
Externí odkaz:
https://doaj.org/article/c08e0828d37949c29e5fec71efd247c6
Autor:
Thu Nguyen Minh Pham, Natarajan Perumal, Caroline Manicam, Marion Basoglu, Stefan Eimer, Dominik C. Fuhrmann, Claus U. Pietrzik, Albrecht M. Clement, Hagen Körschgen, Jana Schepers, Christian Behl
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102943- (2023)
Accumulation of misfolded proteins or perturbation of calcium homeostasis leads to endoplasmic reticulum (ER) stress and is linked to the pathogenesis of neurodegenerative diseases. Hence, understanding the ability of neuronal cells to cope with chro
Externí odkaz:
https://doaj.org/article/2ab18361f6574f718608e4d28f325c01
Autor:
Jiong Hu, Marco Sisignano, Roman Brecht, Natarajan Perumal, Carlo Angioni, Iris-Sofia Bibli, Beate Fisslthaler, Hartmut Kleinert, Norbert Pfeiffer, Ingrid Fleming, Caroline Manicam
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Cytochrome P450 (CYP) signalling pathway has been shown to play a vital role in the vasoreactivity of wild type mouse ophthalmic artery. In this study, we determined the expression, vascular responses and potential mechanisms of the CYP-deri
Externí odkaz:
https://doaj.org/article/7c86336bfbe8447db07c79cc9df5eb60
Autor:
Kristian Nzogang Fomo, Carsten Schmelter, Joshua Atta, Vanessa M. Beutgen, Rebecca Schwarz, Natarajan Perumal, Gokul Govind, Thomas Speck, Norbert Pfeiffer, Franz H. Grus
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Glaucoma is a group of optic neuropathies characterized by the progressive degeneration of retinal ganglion cells (RGCs) as well as their axons leading to irreversible loss of sight. Medical management of the intraocular pressure (IOP) still represen
Externí odkaz:
https://doaj.org/article/be9975dab87343bd95db90f512ed5cbf
Autor:
Carsten Schmelter, Kristian Nzogang Fomo, Alina Brueck, Natarajan Perumal, Sascha D. Markowitsch, Gokul Govind, Thomas Speck, Norbert Pfeiffer, Franz H. Grus
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1161 (2023)
Glaucoma is a complex, multifactorial optic neuropathy mainly characterized by the progressive loss of retinal ganglion cells (RGCs) and their axons, resulting in a decline of visual function. The pathogenic molecular mechanism of glaucoma is still n
Externí odkaz:
https://doaj.org/article/25283b0e702941078922273d250ec03c
Autor:
Pia Grotegut, Natarajan Perumal, Sandra Kuehn, Andreas Smit, H. Burkhard Dick, Franz H. Grus, Stephanie C. Joachim
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-23 (2020)
Abstract Background Previous studies noted that intravitreal injection of S100B triggered a glaucoma-like degeneration of retina and optic nerve as well as microglia activation after 14 days. The precise role of microglia in our intravitreal S100B mo
Externí odkaz:
https://doaj.org/article/c77997c383484aeabed7d22f0e6f0e5d
Autor:
Carsten Schmelter, Alina Brueck, Natarajan Perumal, Sichang Qu, Norbert Pfeiffer, Franz H. Grus
Publikováno v:
Molecules, Vol 28, Iss 2, p 648 (2023)
The glycosylation of proteins is one of the most common post-translational modifications (PTMs) and plays important regulatory functions in diverse biological processes such as protein stability or cell signaling. Accordingly, glycoproteins are also
Externí odkaz:
https://doaj.org/article/938f01d16bc24ec9b0c2288def70ca9f
Autor:
David P. Herzog, Natarajan Perumal, Caroline Manicam, Giulia Treccani, Jens Nadig, Milena Rossmanith, Jan Engelmann, Tanja Jene, Annika Hasch, Michael A. van der Kooij, Klaus Lieb, Nils C. Gassen, Franz H. Grus, Marianne B. Müller
Publikováno v:
Neurobiology of Stress, Vol 15, Iss , Pp 100404- (2021)
Delayed onset of antidepressant action is a shortcoming in depression treatment. Ketamine and its metabolite (2R,6R)-hydroxynorketamine (HNK) have emerged as promising rapid-acting antidepressants. However, their mechanism of action remains unknown.
Externí odkaz:
https://doaj.org/article/d8aba74592bc42718b2bc6bf8e42ffef
Publikováno v:
Cells, Vol 11, Iss 21, p 3494 (2022)
Cytochrome P450 (CYP) gene mutations are a common predisposition associated with glaucoma. Although the molecular mechanisms are largely unknown, omega-3 polyunsaturated fatty acids (ω-3 PUFA) and their CYP-derived bioactive mediators play crucial r
Externí odkaz:
https://doaj.org/article/f2b636b7794e422b888e5b8001c9d995