Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Natarajan Balasubramaniyan"'
Autor:
Natarajan Balasubramaniyan, Michael W. Devereaux, David J. Orlicky, Ronald J. Sokol, Frederick J. Suchy
Publikováno v:
Hepatology Communications, Vol 3, Iss 12, Pp 1674-1686 (2019)
Adenosine triphosphate–binding cassette subfamily C member 2 (ABCC2/Abcc2) is critically important to biliary excretion of many endobiotic and xenobiotic compounds, and is a major driving force for bile acid–independent bile flow. Abcc2 expressio
Externí odkaz:
https://doaj.org/article/aebd4adb52da46959b40f92d286b48d8
Autor:
Karim C. El Kasmi, Padade M. Vue, Aimee L. Anderson, Michael W. Devereaux, Swati Ghosh, Natarajan Balasubramaniyan, Sophie A. Fillon, Carola Dahrenmoeller, Ayed Allawzi, Crystal Woods, Sarah McKenna, Clyde J. Wright, Linda Johnson, Angelo D’Alessandro, Julie A. Reisz, Eva Nozik-Grayck, Frederick J. Suchy, Ronald J. Sokol
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The authors previously developed a mouse model of parenteral nutrition-associated cholestasis (PNAC) that is dependent on parenteral phytosterols and intestinal injury with DSS. Here they refine the model and show that PNAC pathology is dependent on
Externí odkaz:
https://doaj.org/article/2a266070415e43ab8b818dd620dfebf5
Autor:
Francesca Aguilo, SiDe Li, Natarajan Balasubramaniyan, Ana Sancho, Sabina Benko, Fan Zhang, Ajay Vashisht, Madhumitha Rengasamy, Blanca Andino, Chih-hung Chen, Felix Zhou, Chengmin Qian, Ming-Ming Zhou, James A. Wohlschlegel, Weijia Zhang, Frederick J. Suchy, Martin J. Walsh
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 479-492 (2016)
The Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) is a transcriptional co-activator that plays a central role in adapted metabolic responses. PGC-1α is dynamically methylated and unmethylated at the residue K779 by t
Externí odkaz:
https://doaj.org/article/4ddbc33d3daa49898928b13d47416b8c
Autor:
Sandrine Dubrac, Steven R. Lear, Meena Ananthanarayanan, Natarajan Balasubramaniyan, Jaya Bollineni, Sarah Shefer, Hideyuki Hyogo, David E. Cohen, Patricia J. Blanche, Ronald M. Krauss, Ashok K. Batta, Gerald Salen, Frederick J. Suchy, Nobuyo Maeda, Sandra K. Erickson
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 1, Pp 76-85 (2005)
The CYP27A gene encodes a mitochondrial cytochrome P450 enzyme, sterol 27-hydroxylase, that is expressed in many different tissues and plays an important role in cholesterol and bile acid metabolism. In humans, CYP27A deficiency leads to cerebrotendi
Externí odkaz:
https://doaj.org/article/f6777aacfb9c46448d115da3c88a52e5
Autor:
Sandra K. Erickson, Steven R. Lear, Sean Deane, Sandrine Dubrac, Sandra L. Huling, Lien Nguyen, Jaya S. Bollineni, Sarah Shefer, Hideyuki Hyogo, David E. Cohen, Benjamin Shneider, Ephraim Sehayek, Meena Ananthanarayanan, Natarajan Balasubramaniyan, Fredrick J. Suchy, Ashok K. Batta, Gerald Salen
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 5, Pp 1001-1009 (2003)
Cholesterol 7α-hydroxylase, a rate-limiting enzyme for bile acid synthesis, has been implicated in genetic susceptibility to atherosclerosis. The gene, CYP7A1, encoding a protein with this activity, is expressed normally only in hepatocytes and is h
Externí odkaz:
https://doaj.org/article/b1870655655549448295e9a0ea9dcbd8
Autor:
Raman, Rajagopalan, Natarajan, Balasubramaniyan, subbiah, Vijaya, Anandan, Sambandam, Kamalakannan, Shanmugasundaram, Prakash, Muthuramalingam
Publikováno v:
In Optical Materials December 2022 134 Part A
Autor:
Michael W. Devereaux, Frederick J. Suchy, Angelo D'Alessandro, Ronald J. Sokol, Swati Ghosh, Colin T. Shearn, Karim C. El Kasmi, David J. Orlicky, Aimee L. Anderson, Natarajan Balasubramaniyan
Publikováno v:
Hepatology. 75:252-265
Parenteral nutrition (PN)-associated cholestasis (PNAC) complicates the care of patients with intestinal failure. In PNAC, phytosterol containing PN synergizes with intestinal injury and IL-1β derived from activated hepatic macrophages to suppress h
Autor:
Natarajan Balasubramaniyan
Publikováno v:
Natarajan Balasubramaniyan
The Zinc Ferrites (ZnFe2O4) nanoparticles (NPs) successfully synthesized by co-precipitation method. As prepared NPs were annealed withdifferent temperature at 800 and 1000C. The crystalline phase, surface morphology andelemental distribution were
Autor:
David J. Orlicky, Frederick J. Suchy, Aimee L. Anderson, Colin T. Shearn, Michael W. Devereaux, Ronald J. Sokol, Karim C. El Kasmi, Natarajan Balasubramaniyan
Publikováno v:
JPEN. Journal of parenteral and enteral nutritionREFERENCES. 46(5)
BACKGROUND We have recently reported a mouse model of PN-associated cholestasis (PNAC) in which combining intestinal inflammation and PN infusion results in cholestasis, hepatic macrophage activation, and transcriptional suppression of canalicular bi
Autor:
Natarajan Balasubramaniyan, Frederick J. Suchy, David J. Orlicky, Ronald J. Sokol, Michael W. Devereaux
Publikováno v:
The Journal of Biological Chemistry
ATP-binding cassette, sub-family B member 11 (ABCB11) is an efflux transporter for bile acids on the liver canalicular membrane. The expression of this transporter is reduced in cholestasis; however, the mechanisms contributing to this reduction are