Zobrazeno 1 - 10
of 475
pro vyhledávání: '"Natarajan, Muthusamy"'
Autor:
Jessica Nunes, Rakeb Tafesse, Charlene Mao, Matthew Purcell, Xiaokui Mo, Liwen Zhang, Meixiao Long, Matthew G. Cyr, Christoph Rader, Natarajan Muthusamy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Siglec-6 is a lectin receptor with restricted expression in the placenta, mast cells and memory B-cells. Although Siglec-6 is expressed in patients with chronic lymphocytic leukemia (CLL), its pathophysiological role has not been elucidated.
Externí odkaz:
https://doaj.org/article/77c2a2030f1740c4a3efc4a6ce473897
Autor:
Wing Keung Chan, Jessica Williams, Kinnari Sorathia, Betsy Pray, Kaled Abusaleh, Zehua Bian, Archisha Sharma, Ian Hout, Shamama Nishat, Walter Hanel, Shelby L. Sloan, Aneeq Yasin, Nathan Denlinger, Xiaoli Zhang, Natarajan Muthusamy, Sumithira Vasu, Marcos de Lima, Yiping Yang, Robert Baiocchi, Lapo Alinari
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-15 (2023)
Abstract Background Mantle cell lymphoma (MCL) is a rare B-cell non-Hodgkin lymphoma subtype which remains incurable despite multimodal approach including chemoimmunotherapy followed by stem cell transplant, targeted approaches such as the BTK inhibi
Externí odkaz:
https://doaj.org/article/71313e0e10e94b959e6046c399c56a84
Autor:
Logan A. Walker, Michael G. Sovic, Chi-Ling Chiang, Eileen Hu, Jiyeon K. Denninger, Xi Chen, Elizabeth D. Kirby, John C. Byrd, Natarajan Muthusamy, Ralf Bundschuh, Pearlly Yan
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-15 (2020)
Abstract Background Direct cDNA preamplification protocols developed for single-cell RNA-seq have enabled transcriptome profiling of precious clinical samples and rare cell populations without the need for sample pooling or RNA extraction. We term th
Externí odkaz:
https://doaj.org/article/8a786197ad0e41daa5e49c748c1252f5
Autor:
Sara Elgamal, Emanuele Cocucci, Ellen J. Sass, Xiaokui M. Mo, Angela R. Blissett, Edward P. Calomeni, Kerry A. Rogers, Jennifer A. Woyach, Seema A. Bhat, Natarajan Muthusamy, Amy J. Johnson, Karilyn T. Larkin, John C. Byrd
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
In chronic lymphocytic leukemia (CLL) and very likely all cancer types, extracellular vesicles (EVs) are a common mechanism by which intercellular messages are communicated between normal, diseased, and transformed cells. Studies of EVs in CLL and ot
Externí odkaz:
https://doaj.org/article/830710c6a2f04339a049c9c1b33e7304
Autor:
Nyla A. Heerema, Natarajan Muthusamy, Qiuhong Zhao, Amy S. Ruppert, Heather Breidenbach, Leslie A. Andritsos, Michael R. Grever, Kami J. Maddocks, Jennifer Woyach, Farrukh Awan, Meixiao Long, Amber Gordon, Caitlin Coombes, John C. Byrd
Publikováno v:
Haematologica, Vol 106, Iss 6 (2020)
Mutations of the IGH variable region in patients with chronic lymphocytic leukemia (CLL) are associated with a favorable prognosis. Cytogenetic complexity (>3 unrelated aberrations) and translocations have been associated with an unfavorable prognosi
Externí odkaz:
https://doaj.org/article/c1f8c37f9c954bf6a8dafb620cb0ea2a
Autor:
Yo-Ting Tsai, Aparna Lakshmanan, Amy Lehman, Bonnie K. Harrington, Fabienne McClanahan Lucas, Minh Tran, Ellen J. Sass, Meixiao Long, Alan D. Flechtner, Florinda Jaynes, Krista La Perle, Vincenzo Coppola, Gerard Lozanski, Natarajan Muthusamy, John C. Byrd, Michael R. Grever, David M. Lucas
Publikováno v:
Blood Advances, Vol 1, Iss 24, Pp 2147-2160 (2017)
Abstract: Mutated mitogen-activated protein kinase (MAPK) pathway components promote tumor survival, proliferation, and immune evasion in solid tumors. MAPK mutations occur in hematologic cancers as well, but their role is less clear and few models a
Externí odkaz:
https://doaj.org/article/c6e0f46b0f7340d6824ced467f0fcaeb
Autor:
Max Yano, Chia Sharpe, J. Rachel Lance, Janani Ravikrishnan, Kevan Zapolnik, Xiaokui Mo, Jennifer A. Woyach, Deepa Sampath, Adam S. Kittai, Sumithira Vasu, Seema Bhat, Kerry A. Rogers, Dean A. Lee, Natarajan Muthusamy, John C. Byrd
Publikováno v:
Blood Advances. 6:5641-5654
Successes with anti-CD20 antibodies in chronic lymphocytic leukemia (CLL) and enhanced activity of Fc-engineered vs unmodified antibody therapy suggest a potentially impactful role for natural killer (NK) cells and other innate immune cells in contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff7d9c8eee3c64f177101fec5cc3cd6
https://doi.org/10.1182/bloodadvances.2021005883
https://doi.org/10.1182/bloodadvances.2021005883
Autor:
Max Yano, Jessica Nunes, Xiaokui Mo, Kerry A. Rogers, Jennifer A. Woyach, John C. Byrd, Natarajan Muthusamy
Publikováno v:
Blood Advances. 6:5440-5448
Cytotoxic T lymphocyte antigen 4 (CTLA4) is a major immune checkpoint and target for cancer immunotherapy. Although originally discovered and primarily studied on T cells, its role on other cell types has also been recognized in recent years. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33feaecb8feba74739f0d02803d26df7
https://doi.org/10.1182/bloodadvances.2021005571
https://doi.org/10.1182/bloodadvances.2021005571
Autor:
James P. Collard, Mary K. McKenna, Sunil K. Noothi, Sara S. Alhakeem, Jacqueline R. Rivas, Vivek M. Rangnekar, Natarajan Muthusamy, Subbarao Bondada
Publikováno v:
Leukemia & Lymphoma. 63:1810-1822
The chronic lymphocytic leukemia (CLL) microenvironment has been receiving an increasing amount of attention, but there is currently limited data surrounding how the microenvironment affects initial development of CLL. We determined that the spleen i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1eddd657d553309959bf664036a9991
https://doi.org/10.1080/10428194.2022.2045596
https://doi.org/10.1080/10428194.2022.2045596
Autor:
Jürgen Moll, Natarajan Muthusamy, Norbert Kraut, Darryl B. McConnell, Mark Pearson, Segundo Gonzalez, Peter Ettmayer, Sumithira Vasu, Swagata Goswami, Girish Rajgolikar, Michael P. Sanderson, Thomas Gerstberger, Renate Schnitzer, Andreas Zoephel, Heribert Arnhof, Dirk Scharn, Jark Böttcher, Seila Lorenzo-Herrero, Marc Kerenyi, Sebastian Carotta, Maria A. Impagnatiello, Harald Engelhardt, Rajeswaran Mani, Marco H. Hofmann
Supplementary Data including Table S1-Table S5 and Figure S1 - Figure S9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d553495bd4441df245e0ecc2903f83f
https://doi.org/10.1158/1535-7163.22520835
https://doi.org/10.1158/1535-7163.22520835
