Zobrazeno 1 - 10
of 509
pro vyhledávání: '"Natarajan, Kannan"'
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Fructosamine-3-kinases (FN3Ks) are a conserved family of repair enzymes that phosphorylate reactive sugars attached to lysine residues in peptides and proteins. Although FN3Ks are present across the Tree of Life and share detectable sequence
Externí odkaz:
https://doaj.org/article/4538014328d94853bd8449e652e1b0c6
Autor:
Neuenschwander, Beat, Roychoudhury, Satrajit, Wandel, Simon, Natarajan, Kannan, Zuber, Emmanuel
The call for patient-focused drug development is loud and clear, as expressed in the 21st Century Cures Act and in recent guidelines and initiatives of regulatory agencies. Among the factors contributing to modernized drug development and improved he
Externí odkaz:
http://arxiv.org/abs/2112.10404
Autor:
Yanxiang Meng, Sarah E. Garnish, Katherine A. Davies, Katrina A. Black, Andrew P. Leis, Christopher R. Horne, Joanne M. Hildebrand, Hanadi Hoblos, Cheree Fitzgibbon, Samuel N. Young, Toby Dite, Laura F. Dagley, Aarya Venkat, Natarajan Kannan, Akiko Koide, Shohei Koide, Alisa Glukhova, Peter E. Czabotar, James M. Murphy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The necroptosis pathway is a lytic, pro-inflammatory mode of cell death that is widely implicated in human disease, including renal, pulmonary, gut and skin inflammatory pathologies. The precise mechanism of the terminal steps in the pathway
Externí odkaz:
https://doaj.org/article/3125421e28064554a4a1522779b6993c
Autor:
Hipólito Nicolás Cuesta-Hernández, Julia Contreras, Pablo Soriano-Maldonado, Jana Sánchez-Wandelmer, Wayland Yeung, Ana Martín-Hurtado, Inés G. Muñoz, Natarajan Kannan, Marta Llimargas, Javier Muñoz, Iván Plaza-Menacho
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Autophosphorylation controls the transition between discrete functional and conformational states in protein kinases, yet the structural and molecular determinants underlying this fundamental process remain unclear. Here we show that c-termi
Externí odkaz:
https://doaj.org/article/c3b166424ee543e296abfd732eab6d76
Autor:
Jones, Charles H., Madhavan, Subha, Natarajan, Kannan, Corbo, Michael, True, Jane M., Dolsten, Mikael
Publikováno v:
In Drug Discovery Today September 2024 29(9)
Autor:
Saber Soleymani, Nathan Gravel, Liang-Chin Huang, Wayland Yeung, Elika Bozorgi, Nathaniel G. Bendzunas, Krzysztof J. Kochut, Natarajan Kannan
Publikováno v:
PeerJ, Vol 11, p e16087 (2023)
The Protein Kinase Ontology (ProKinO) is an integrated knowledge graph that conceptualizes the complex relationships among protein kinase sequence, structure, function, and disease in a human and machine-readable format. In this study, we have signif
Externí odkaz:
https://doaj.org/article/78b90c5c43b64d39a100206dd4b76e41
Autor:
Aarya Venkat, Grace Watterson, Dominic P Byrne, Brady O'Boyle, Safal Shrestha, Nathan Gravel, Emma E Fairweather, Leonard A Daly, Claire Bunn, Wayland Yeung, Ishan Aggarwal, Samiksha Katiyar, Claire E Eyers, Patrick A Eyers, Natarajan Kannan
Publikováno v:
eLife, Vol 12 (2023)
Catalytic signaling outputs of protein kinases are dynamically regulated by an array of structural mechanisms, including allosteric interactions mediated by intrinsically disordered segments flanking the conserved catalytic domain. The doublecortin-l
Externí odkaz:
https://doaj.org/article/f4f43ea236f54c43b1f0fe6ed2bbb536
Autor:
Mariah V. Salcedo, Nathan Gravel, Abbas Keshavarzi, Liang-Chin Huang, Krzysztof J. Kochut, Natarajan Kannan
Publikováno v:
PeerJ, Vol 11, p e15815 (2023)
The 534 protein kinases encoded in the human genome constitute a large druggable class of proteins that include both well-studied and understudied “dark” members. Accurate prediction of dark kinase functions is a major bioinformatics challenge. H
Externí odkaz:
https://doaj.org/article/f9a6f8aea0fa42169043d7129c3f323f
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Pneumococcal pneumonia remains a WHO high-priority disease despite multivalent conjugate vaccines administered in clinical practice worldwide. A protein-based, serotype-independent vaccine has long-promised comprehensive coverage of most cli
Externí odkaz:
https://doaj.org/article/7ab18a78e12f48469744497f1a264f16
Autor:
Shanmuga, Sundar S., Natarajan, Kannan, Zsolt, Sarang, Priya, Lakshminarayanan Srimathi, Ayyar, Manikandan, Anboo, Sasikala, Nissapatorn, Veeranoot, Jonna, Narendranath, Vasanthapalaniappan, Kamalakannan, Packirisamy, Rajavelu, Dolma, Karma Gyurmey
Publikováno v:
Zeitschrift für Physikalische Chemie; Jul2024, Vol. 238 Issue 7, p1345-1360, 16p