Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Natanael Spisak"'
Publikováno v:
eLife, Vol 13 (2024)
B-cell repertoires are characterized by a diverse set of receptors of distinct specificities generated through two processes of somatic diversification: V(D)J recombination and somatic hypermutations. B-cell clonal families stem from the same V(D)J r
Externí odkaz:
https://doaj.org/article/e9640bc963ad4785be72a3e83d8576f9
Autor:
Christoph Kreer, Cosimo Lupo, Meryem S. Ercanoglu, Lutz Gieselmann, Natanael Spisak, Jan Grossbach, Maike Schlotz, Philipp Schommers, Henning Gruell, Leona Dold, Andreas Beyer, Armita Nourmohammad, Thierry Mora, Aleksandra M. Walczak, Florian Klein
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract HIV-1 broadly neutralizing antibodies (bNAbs) are able to suppress viremia and prevent infection. Their induction by vaccination is therefore a major goal. However, in contrast to antibodies that neutralize other pathogens, HIV-1-specific bN
Externí odkaz:
https://doaj.org/article/e900725c8c9741e5a635d16c5aac862f
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010652 (2023)
Adaptive immunity's success relies on the extraordinary diversity of protein receptors on B and T cell membranes. Despite this diversity, the existence of public receptors shared by many individuals gives hope for developing population-wide vaccines
Externí odkaz:
https://doaj.org/article/bb2bc1f4fbc1448596f53841e4f6c619
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010167 (2022)
Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations of the immunoglobulin gene. It also includes deletions and insertions o
Externí odkaz:
https://doaj.org/article/973030ca05f644d6a2d14d1d90e625c6
Autor:
Christoph Kreer, Cosimo Lupo, Meryem S. Ercanoglu, Lutz Gieselmann, Natanael Spisak, Jan Grossbach, Maike Schlotz, Philipp Schommers, Henning Gruell, Leona Dold, Andreas Beyer, Armita Nourmohammad, Thierry Mora, Aleksandra M. Walczak, Florian Klein
HIV-1 broadly neutralizing antibodies (bNAbs) are able to suppress viremia and prevent infection. Their induction by vaccination is therefore a major goal. However, in contrast to antibodies that neutralize other pathogens, HIV-1-specific bNAbs frequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0deefd9e2906fa19b52d9dc926238edf
https://doi.org/10.1101/2022.07.11.499584
https://doi.org/10.1101/2022.07.11.499584
Publikováno v:
Phys Rev E
Simulation-based inference enables learning the parameters of a model even when its likelihood cannot be computed in practice. One class of methods uses data simulated with different parameters to infer models of the likelihood-to-evidence ratio, or
B-cell repertoires are characterized by a diverse set of receptors of distinct specificities generated through two processes of somatic diversification: V(D)J recombination and somatic hypermutations. B cell clonal families stem from the same V(D)J r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd939257b5bf318a62c8fcdada003d83
Publikováno v:
bioRxiv
Adaptive immunity’s success relies on the extraordinary diversity of protein receptors on B and T cell membranes. Despite this diversity, the existence of public receptors shared by many individuals gives hope for developing population wide vaccine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b258780b277a1022bdb85d715837d2b
https://doi.org/10.1101/2021.12.17.473105
https://doi.org/10.1101/2021.12.17.473105
Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations of the immunoglobulin gene. It also includes deletions and insertions o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3cd11d06b3ec1906067122333efdab
http://arxiv.org/abs/2112.07953
http://arxiv.org/abs/2112.07953
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, 48, pp.10702-10712. ⟨10.1093/nar/gkaa825⟩
Nucleic Acids Research, Oxford University Press, 2020, 48, pp.10702-10712. ⟨10.1093/nar/gkaa825⟩
Somatic hypermutations of immunoglobulin (Ig) genes occurring during affinity maturation drive B-cell receptors’ ability to evolve strong binding to their antigenic targets. The landscape of these mutations is highly heterogeneous, with certain reg