NK-92 cells retain vitality and functionality when grown in standard cell culture conditions

Autor: Rebecca Kotzur, Alexandra Duev-Cohen, Inbal Kol, Adi Reches, Ofer Mandelboim, Natan Stein

Publikováno v: PLoS ONE, Vol 17, Iss 3 (2022)

NK-92 cells are an off-the-shelf, cell-based immunotherapy currently in clinical trials for a variety of cancer types. As the most ‘NK-like’ cell line available, it is also an important research tool. To date, NK-92 cells have been cultivated in

Externí odkaz: https://doaj.org/article/401963b8101f47fc94e660f5469724ec

Nectin4 is a novel TIGIT ligand which combines checkpoint inhibition and tumor specificity

Autor: Barbara Seliger, Adi Reches, Yael Ophir, Natan Stein, Inbal Kol, Batya Isaacson, Yoav Charpak Amikam, Afek Elnekave, Pinchas Tsukerman, Paola Kucan Brlic, Tihana Lenac, Stipan Jonjic

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Background The use of checkpoint inhibitors has revolutionized cancer therapy. Unfortunately, these therapies often cause immune-related adverse effects, largely due to a lack of tumor specificity.Methods We stained human natural killer cells using f

Externí odkaz: https://doaj.org/article/45b2224866764c9a9d776a55b1156865

High percentages and activity of synovial fluid NK cells present in patients with advanced stage active Rheumatoid Arthritis

Autor: Chamutal Gur, Issam Hindi, Natan Stein, Anat Scheiman-Elazary, Suhail Aamar, Rachel Yamin, Orit Berhani, Moriya Gamliel, Hagit Peleg

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports

Rheumatoid Arthritis (RA) causes chronic inflammation of joints. The cytokines TNFα and IFNγ are central players in RA, however their source has not been fully elucidated. Natural Killer (NK) cells are best known for their role in elimination of vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c539d2d165b2a69ef58ca201b97fc117
http://link.springer.com/article/10.1038/s41598-018-37448-z

Nectin4 is a novel TIGIT ligand which combines checkpoint inhibition and tumor specificity

Autor: Tihana Lenac, Inbal Kol, Yoav Charpak Amikam, Batya Isaacson, Barbara Seliger, Paola Kucan Brlic, Afek Elnekave, Pinchas Tsukerman, Adi Reches, Yael Ophir, Stipan Jonjić, Natan Stein, Ofer Mandelboim

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer
Volume 8
Issue 1

BackgroundThe use of checkpoint inhibitors has revolutionized cancer therapy. Unfortunately, these therapies often cause immune-related adverse effects, largely due to a lack of tumor specificity.MethodsWe stained human natural killer cells using fus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9090aa95b550fc939ddbb1d63a507f5f
https://jitc.bmj.com/content/8/1/e000266.full

NK Cell Recognition of Candida glabrata through Binding of NKp46 and NCR1 to Fungal Ligands Epa1, Epa6, and Epa7

Autor: Brendan P. Cormack, Yoav Charpak-Amikam, Chamutal Gur, Ofer Mandelboim, Moriya Gamliel, Liat Dassa, Ronen Ben-Ami, Rachel Yamin, Alon Vitenshtein, Nir Osherov, Carlos Gomez, Orit Berhani, Yoav Bauman, Ariella Glasner, Batya Isaacson, Natan Stein

Publikováno v: Cell hostmicrobe. 20(4)

Natural killer (NK) cells form an important arm of the innate immune system and function to combat a wide range of invading pathogens, ranging from viruses to bacteria. However, the means by which NK cells accomplish recognition of pathogens with a l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e18e1deeba5050dda9578b9db938dc
https://pubmed.ncbi.nlm.nih.gov/27816327