Zobrazeno 1 - 10 of 93 pro vyhledávání: '"Natalya U, Fedosova"'
1
Akademický článek
N-3-Methylbutyl-benzisoselenazol-3(2H)-one Exerts Antifungal Activity In Vitro and in a Mouse Model of Vulvovaginal Candidiasis
Autor: Xiuyi Liang, Agata J. Pacuła-Miszewska, Richa Vartak, Milankumar Prajapati, Haiyan Zheng, Caifeng Zhao, Ganming Mao, Ketankumar Patel, Natalya U. Fedosova, Jacek Ścianowski, Blase Billack
Publikováno v: Current Issues in Molecular Biology, Vol 46, Iss 3, Pp 2480-2496 (2024)
In the present work, we evaluated the antifungal activities of two novel ebselen analogs, N-allyl-benzisoselenazol-3(2H)-one (N-allyl-bs) and N-3-methylbutylbenzisoselenazol-3(2H)-one (N-3mb-bs). Colorimetric and turbidity assays were performed to de
Externí odkaz: https://doaj.org/article/4a91e05672c8411f90f04ef30d76a8e7
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2
Akademický článek
Selected N-Terpenyl Organoselenium Compounds Possess Antimycotic Activity In Vitro and in a Mouse Model of Vulvovaginal Candidiasis
Autor: Xiuyi Liang, Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Richa Vartak, Ganming Mao, Ketankumar Patel, Natalya U. Fedosova, Jacek Ścianowski, Blase Billack
Publikováno v: Molecules, Vol 28, Iss 21, p 7377 (2023)
In the present work, a series of N-terpenyl organoselenium compounds (CHB1-6) were evaluated for antimycotic activity by determining the minimum inhibitory concentration (MIC) for each compound in fluconazole (FLU)-sensitive (S1) and FLU-resistant (S
Externí odkaz: https://doaj.org/article/e385197d90344e9a947b7182c2dbc7ca
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4
Benzamil-mediated urine alkalization is caused by the inhibition of H+-K+-ATPases
Autor: Jesper Frank Andersen, Charles S. Wingo, Jens Leipziger, Niklas Ayasse, I. Jeanette Lynch, Natalya U. Fedosova, Samuel L Svendsen, Mads V. Sorensen, Peder Berg
Publikováno v: Ayasse, N, Berg, P, Andersen, J F, Svendsen, S L S C, Sørensen, M V, Fedosova, N, Wingo, C, Lynch, I J & Leipziger, J G 2021, ' Benzamil-mediated urine alkalization is caused by the inhibition of H +, K + ATPases ', American Journal of Physiology: Renal Physiology, vol. 320, no. 4, pp. F596-F607 . https://doi.org/10.1152/ajprenal.00444.2020
Epithelial Na+ channel (ENaC) blockers elicit acute and substantial increases of urinary pH. The underlying mechanism remains to be understood. Here, we evaluated if benzamil-induced urine alkalization is mediated by an acute reduction in H+ secretio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb42c5990e38c42a7751b24b66b2eba
https://doi.org/10.1152/ajprenal.00444.2020
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6
The Na,K-ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state
Autor: Marlene U. Fruergaard, Ingrid Dach, Jacob L. Andersen, Mette Ozol, Azadeh Shahsavar, Esben M. Quistgaard, Hanne Poulsen, Natalya U. Fedosova, Poul Nissen
Publikováno v: Fruergaard, M U, Dach, I, Andersen, J L, Ozol, M, Shasavar, A, Quistgaard, E M H, Poulsen, H, Fedosova, N & Nissen, P 2022, ' The Na,K-ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state. ', Journal of Biological Chemistry, vol. 298, no. 9, 102317 . https://doi.org/10.1016/j.jbc.2022.102317
The journal of biological chemistry 298(9), 102317 (2022). doi:10.1016/j.jbc.2022.102317
JBC papers in press 298(9), 102317 (2022). doi:10.1016/j.jbc.2022.102317
The Na$^+$,K$^+$-ATPase generates electrochemical gradients of Na$^+$ and K$^+$ across the plasma membrane via a functional cycle that includes various phosphoenzyme interm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42c5d3878478c4bbbcd9041ed40d9ee
https://pure.au.dk/portal/da/publications/the-nakatpase-in-complex-with-beryllium-fluoride-mimics-an-atpase-phosphorylated-state(1db2fbbb-0727-405f-83c3-8325e923b576).html
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7
Measurements of Na+-occluded intermediates during the catalytic cycle of the Na+/K+-ATPase provide novel insights into the mechanism of Na+ transport
Autor: Santiago E. Faraj, Wanda M. Valsecchi, Mariela Ferreira-Gomes, Mercedes Centeno, Elina Malén Saint Martin, Natalya U. Fedosova, Juan Pablo FC. Rossi, Mónica R. Montes, Rolando C. Rossi
Publikováno v: Faraj, S E, Valsecchi, W M, Ferreira-Gomes, M, Centeno, M, Saint Martin, E M S, Fedosova, N, Rossi, J P F C, Montes, M & Rossi, R C 2023, ' Measurements of Na+-occluded intermediates during the catalytic cycle of the Na+/K+-ATPase provide novel insights into the mechanism of Na+ transport ', Journal of Biological Chemistry . https://doi.org/10.1016/j.jbc.2022.102811
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0cf47f4cd05d6f1accab6520063c5ba
https://doi.org/10.1016/j.jbc.2022.102811
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8
The beryllium fluoride form of the Na+,K+-ATPase and the intermediates of the functional cycle
Autor: Azadeh Shasavar, Hanne Poulsen, Natalya U. Fedosova, Mette Ozol, Marlene U. Fruergaard, Jacob Andersen, Poul Nissen, Esben M. Quistgaard, Ingrid Dach
The Na+,K+-ATPase generates electrochemical gradients of Na+ and K+ across the plasma membrane. Here, we describe a 4.0 Å resolution crystal structure of the pig kidney Na+,K+-ATPase stabilized by beryllium fluoride (denoted E2-BeFx). The structure
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc2f8eacb851cca5c4db14deb9fcd1c8
https://doi.org/10.1101/2021.11.08.467847
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9
Geometry and water accessibility of the inhibitor binding site of Na+-pump:Pulse- and CW-EPR study
Autor: Ren-Wang Jiang, Natalya U. Fedosova, Derek Marsh, Rosa Bartucci, Jin-Hua Guo, Erika Aloi, Lucy Kate Ladefoged, Mikael Esmann, Rita Guzzi
Publikováno v: Aloi, E, Guo, J H, Guzzi, R, Jiang, R W, Ladefoged, L K, Marsh, D, Esmann, M, Bartucci, R & Fedosova, N U 2021, ' Geometry and water accessibility of the inhibitor binding site of Na +-pump : Pulse-and CW-EPR study ', Biophysical Journal, vol. 120, no. 13, pp. 2679-2690 . https://doi.org/10.1016/j.bpj.2021.05.018
Spin labels based on cinobufagin, a specific inhibitor of the Na,K-ATPase, have proved valuable tools to characterize the binding site of cardiotonic steroids (CTSs), which also constitutes the extracellular cation pathway. Because existing literatur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771be57af7ec0adefc2aecf64a629bb1
https://pure.au.dk/portal/da/publications/geometry-and-water-accessibility-of-the-inhibitor-binding-site-of-napump(62a38489-ca08-4e8b-a50b-3569b2d1d1a6).html
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