Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Natalya Seredkina"'
Autor:
Dhivya Thiyagarajan, Hege L. Pedersen, Natalya Seredkina, Kjersti D. Horvei, Lorena Arranz, Ramon Sonneveld, Tom Nijenhuis, Johan van der Vlag, Ole P. Rekvig
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Recently we described that endonuclease inactive DNase I translocated into the nucleus in response to increased endogenous IL-1β expression. Here, we demonstrate impact and function of translocated DNase I in tubular cells. Effect of cytokines on ex
Externí odkaz:
https://doaj.org/article/d4988ea9b4414b269dc994d85dfdd27a
Autor:
Kjersti Daae Horvei, Hege Lynum Pedersen, Silje Fismen, Dhivya Thiyagarajan, Andrea Schneider, Ole Petter Rekvig, Thomas H Winkler, Natalya Seredkina
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188863 (2017)
FcγRIIB-/-yaa mice develop severe lupus glomerulonephritis due to lack of an inhibitory immune cell receptor combined with a Y-chromosome linked autoimmune accelerator mutation. In the present study, we have investigated nephritis development and pr
Externí odkaz:
https://doaj.org/article/e2576dc027e14fcab0d095178ea53b38
Publikováno v:
Molecular Medicine, Vol 19, Iss 1, Pp 161-169 (2013)
Abstract Autoantibodies to components of chromatin, which include double-stranded DNA (dsDNA), histones and nucleosomes, are central in the pathogenesis of lupus nephritis. How anti-chromatin autoantibodies exert their nephritogenic activity, however
Externí odkaz:
https://doaj.org/article/95f37a4639644a489c858aab733e9b9b
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129485 (2015)
We have demonstrated that the renal endonuclease DNaseI is up-regulated in mesangial nephritis while down-regulated during progression of the disease. To determine the basis for these reciprocal DNaseI expression profiles we analyse processes account
Externí odkaz:
https://doaj.org/article/6120f2f503fe441e908a43ecf03d7dad
Autor:
Dhivya Thiyagarajan, Silje Fismen, Natalya Seredkina, Søren Jacobsen, Thomas Elung-Jensen, Anne-Lise Kamper, Christopher Graham Fenton, Ole Petter Rekvig, Elin Synnøve Mortensen
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34080 (2012)
Recent studies demonstrate that transformation of mild lupus nephritis into end-stage disease is imposed by silencing of renal DNaseI gene expression in (NZBxNZW)F1 mice. Down-regulation of DNaseI results in reduced chromatin fragmentation, and in de
Externí odkaz:
https://doaj.org/article/c26c61e448d443bc8c418af79aa4a0f8
Autor:
Kristin Fenton, Silje Fismen, Annica Hedberg, Natalya Seredkina, Chris Fenton, Elin Synnøve Mortensen, Ole Petter Rekvig
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8474 (2009)
BACKGROUND:Lupus nephritis is characterized by deposition of chromatin fragment-IgG complexes in the mesangial matrix and glomerular basement membranes (GBM). The latter defines end-stage disease. METHODOLOGY/PRINCIPALS: In the present study we deter
Externí odkaz:
https://doaj.org/article/e78c062ddb8641c2be7670a0f7356db3
Autor:
Dhivya Thiyagarajan, Gabriella Moroni, Gunnstein Bakland, Natalya Seredkina, Ole Petter Rekvig, Erik H. Strøm, Hallvard Holdaas, Pier Luigi Meroni, Gudrun E. Norby, Hege Lynum Pedersen, Kjersti Daae Horvei, Gro Østli Eilertsen
Publikováno v:
The Journal of Pathology: Clinical Research. 4:193-203
Renal DNase I is lost in advanced stages of lupus nephritis. Here, we determined if loss of renal DNase I reflects a concurrent loss of urinary DNase I, and whether absence of urinary DNase I predicts disease progression. Mouse and human DNase I prot
Autor:
Ole Petter Rekvig, Dhivya Thiyagarajan, Hege Lynum Pedersen, Natalya Seredkina, Kjersti Daae Horvei
Publikováno v:
The American Journal of Pathology. 186:2772-2782
Divergent incommensurable models have been developed to explain the pathogenesis of lupus nephritis. Most contemporary models favor a central role for anti-chromatin antibodies. How they exert their pathogenic effect has, however, endorsed conflicts
Autor:
Ole Petter Rekvig, Natalya Seredkina, Thomas Winkler, Kjersti Daae Horvei, Andrea Schneider, Silje Fismen, Hege Lynum Pedersen, Dhivya Thiyagarajan
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188863 (2017)
PLoS ONE
PLoS ONE
Source at https://doi.org/10.1371/journal.pone.0188863 . FcγRIIB-/-yaa mice develop severe lupus glomerulonephritis due to lack of an inhibitory immune cell receptor combined with a Y-chromosome linked autoimmune accelerator mutation. In the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026bc429649ab0835ebcb26fa4a62086
https://hdl.handle.net/10037/12181
https://hdl.handle.net/10037/12181
Autor:
Natalya Seredkina, Ole Petter Rekvig, Kjersti Daae Horvei, Dhivya Thiyagarajan, Hege Lynum Pedersen
Publikováno v:
Seminars in Nephrology. 35:427-438
Lupus nephritis is one of the most serious manifestations of systemic lupus erythematosus, and represents one of the criteria implemented to classify systemic lupus erythematosus. Although studied for decades, no consensus has been reached related to