Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Natalya P. Maharaj"'
Autor:
Ricardo Rajsbaum, Randy A Albrecht, May K Wang, Natalya P Maharaj, Gijs A Versteeg, Estanislao Nistal-Villán, Adolfo García-Sastre, Michaela U Gack
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1003059 (2012)
Influenza A viruses can adapt to new host species, leading to the emergence of novel pathogenic strains. There is evidence that highly pathogenic viruses encode for non-structural 1 (NS1) proteins that are more efficient in suppressing the host immun
Externí odkaz:
https://doaj.org/article/68e798ffdedb4154898c30314604fbb4
Publikováno v:
Journal of Virology. 86:1358-1371
Retinoic acid-inducible gene I (RIG-I) is a key sensor for viral RNA in the cytosol, and it initiates a signaling cascade that leads to the establishment of an interferon (IFN)-mediated antiviral state. Because of its integral role in immune signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a480e821f9bd00a9405b3973808503b
https://doi.org/10.1128/jvi.06543-11
https://doi.org/10.1128/jvi.06543-11
Autor:
Rong Wang, Estanislao Nistal-Villán, Gustavo Martinez-Delgado, Jae U. Jung, Michaela U. Gack, Aneel K. Aggarwal, Kyung-Soo Inn, Adolfo García-Sastre, Natalya P. Maharaj, Heyi Yang
Publikováno v:
The Journal of Biological Chemistry
RIG-I (retinoic acid-inducible gene I) and TRIM25 (tripartite motif protein 25) have emerged as key regulatory factors to induce interferon (IFN)-mediated innate immune responses to limit viral replication. Upon recognition of viral RNA, TRIM25 E3 li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a632cc32cef3ba0ab125d77e45e18a96
https://doi.org/10.1074/jbc.m109.089912
https://doi.org/10.1074/jbc.m109.089912
Autor:
Eric Stavale, Dominique J. Burri, Mary A. Rodgers, Kelly L. Warfield, Michaela U. Gack, Valerie A. Villareal, Margot Carocci, Stephen M. Hinshaw, Priscilla L. Yang, Rajendra Pilankatta, Natalya P. Maharaj
Publikováno v:
Antimicrobial Agents and Chemotherapy
Dengue virus (DENV), a member of the Flaviviridae family, is a mosquito-borne pathogen and the cause of dengue fever. The increasing prevalence of DENV worldwide heightens the need for an effective vaccine and specific antivirals. Due to the dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8d1637778ae6407ceffc71ce4bf94b
https://europepmc.org/articles/PMC4291433/
https://europepmc.org/articles/PMC4291433/
Publikováno v:
Biophysical Journal. 96(3)
Buforin II (BF2) is a 21 amino acid long antimicrobial peptide. Unlike many antimicrobial peptides that induce cell death by disrupting the cellular membrane, BF2 exhibits potent antimicrobial activity without significant membrane permeabilization. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e957b6072c7bcce541aa76c55b00c6
Publikováno v:
Proteins. 73(2)
Buforin II is a 21-amino acid polycationic antimicrobial peptide derived from a peptide originally isolated from the stomach tissue of the Asian toad Bufo bufo gargarizans. It is hypothesized to target a wide range of bacteria by translocating into c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcd83c59449a951b36464e9ecd5ff03
https://pubmed.ncbi.nlm.nih.gov/18452210
https://pubmed.ncbi.nlm.nih.gov/18452210
Publikováno v:
Biophysical Journal. 96(3):456a-457a
Many antimicrobial peptides elicit bacterial death via cell membrane lysis. However, buforin II (BF2), a 21-amino acid peptide derived from histone H2A, is unique due to its hypothesized ability to translocate across cell membranes and interact with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2201a7f6c08c0a807d9d96cfb4df7427
Autor:
Effi Wies, Shenghua Zhou, Natalya P. Maharaj, Robert W. Finberg, Michaela U. Gack, May K. Wang, Kan Chen
Publikováno v:
Cytokine. 63:309
Innate sensing of viral infection and the subsequent activation of signaling pathways are essential for an effective antiviral immune response. Retinoic acid-inducible gene-I (RIG-I; also called DDX58) and melanoma differentiation-associated gene 5 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b55440d15db3872be4c940ba89ce31f8
https://doi.org/10.1016/j.cyto.2013.06.283
https://doi.org/10.1016/j.cyto.2013.06.283
Autor:
Estanislao Nistal-Villán, Gijs A. Versteeg, Randy A. Albrecht, May K. Wang, Natalya P. Maharaj, Michaela U. Gack, Adolfo García-Sastre, Ricardo Rajsbaum
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 8, Iss 11, p e1003059 (2012)
PLoS Pathogens, Vol 8, Iss 11, p e1003059 (2012)
Influenza A viruses can adapt to new host species, leading to the emergence of novel pathogenic strains. There is evidence that highly pathogenic viruses encode for non-structural 1 (NS1) proteins that are more efficient in suppressing the host immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f9e33d8e98dbc2615657c6cbc66015
https://doi.org/10.1371/journal.ppat.1003059
https://doi.org/10.1371/journal.ppat.1003059
Autor:
Michaela U. Gack, Shenghua Zhou, Robert W. Finberg, Kan Chen, Effi Wies, Natalya P. Maharaj, May K. Wang
Publikováno v:
Immunity. (3):437-449
SummaryRIG-I and MDA5 have emerged as key cytosolic sensors for the detection of RNA viruses and lead to antiviral interferon (IFN) production. Recent studies have highlighted the importance of posttranslational modifications for controlling RIG-I an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbc0423186e656361039879b840a648