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of 3
pro vyhledávání: '"Natalya P. Degtyareva"'
Autor:
Libertad García-Villada, Natalya P. Degtyareva, Ashley M. Brooks, Joanna B. Goldberg, Paul W. Doetsch
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Pseudomonas aeruginosa is a major cause of nosocomial infections and the leading cause of chronic lung infections in cystic fibrosis and chronic obstructive pulmonary disease patients. Antibiotic treatment remains challenging because P. aeru
Externí odkaz:
https://doaj.org/article/941eb32df4344fcd83e39f2e70f669eb
Autor:
Natalya P Degtyareva, Natalie Saini, Joan F Sterling, Victoria C Placentra, Leszek J Klimczak, Dmitry A Gordenin, Paul W Doetsch
Publikováno v:
PLoS Biology, Vol 17, Iss 5, p e3000263 (2019)
Redox stress is a major hallmark of cancer. Analysis of thousands of sequenced cancer exomes and whole genomes revealed distinct mutational signatures that can be attributed to specific sources of DNA lesions. Clustered mutations discovered in severa
Externí odkaz:
https://doaj.org/article/4c3ff0f686cc4d048ee35d631a2cecd5
Autor:
Natalya P Degtyareva, Victoria C Placentra, Scott A Gabel, Leszek J Klimczak, Dmitry A Gordenin, Brett A Wagner, Garry R Buettner, Geoffrey A Mueller, Tatyana I Smirnova, Paul W Doetsch
Publikováno v:
Nucleic Acids Res
Mutational signatures discerned in cancer genomes, in aging tissues and in cells exposed to toxic agents, reflect complex processes underlying transformation of cells from normal to dysfunctional. Due to its ubiquitous and chronic nature, redox stres