Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Natalya N, Pavlova"'
Autor:
Natalya N Pavlova, Bryan King, Rachel H Josselsohn, Sara Violante, Victoria L Macera, Santosha A Vardhana, Justin R Cross, Craig B Thompson
Publikováno v:
eLife, Vol 9 (2020)
An inadequate supply of amino acids leads to accumulation of uncharged tRNAs, which can bind and activate GCN2 kinase to reduce translation. Here, we show that glutamine-specific tRNAs selectively become uncharged when extracellular amino acid availa
Externí odkaz:
https://doaj.org/article/c0e10590233a43bb8289ff88a95f070b
Publikováno v:
Holland‐Frei Cancer Medicine. :1-14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fa7b75a08caa6c87643e6ed72a186e7
https://doi.org/10.1002/9781119000822.hfcm015.pub2
https://doi.org/10.1002/9781119000822.hfcm015.pub2
Autor:
Pablo Ranea-Robles, Natalya N Pavlova, Aaron Bender, Andrea S Pereyra, Jessica M Ellis, Brandon Stauffer, Chunli Yu, Craig B Thompson, Carmen Argmann, Michelle Puchowicz, Sander M Houten
Publikováno v:
Cardiovasc Res
Aims Cardiomyopathy and arrhythmias can be severe presentations in patients with inherited defects of mitochondrial long-chain fatty acid β-oxidation (FAO). The pathophysiological mechanisms that underlie these cardiac abnormalities remain largely u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7961f1286b7ec77ba33a5ec0c170aaf1
https://doi.org/10.1093/cvr/cvac050
https://doi.org/10.1093/cvr/cvac050
Publikováno v:
Cell Metab
Metabolism of cancer cells is geared towards biomass production and proliferation. Since the metabolic resources within the local tissue are finite, this can lead to nutrient depletion and accumulation of metabolic waste. To maintain growth in these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3c19dcb1f62f8c00ae9270a33bba13
https://doi.org/10.1016/j.cmet.2022.01.007
https://doi.org/10.1016/j.cmet.2022.01.007
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)
A challenge of targeting glutamine metabolism in cancer is that tumor cells develop various strategies to adapt to glutamine limitation. We found that asparagine plays a critical role in supporting protein synthesis during glutamine starvation, highl
Externí odkaz:
https://doaj.org/article/f878323b7cd04bb48af28579dc095d75
Autor:
Xin Cai, Simon Schwörer, Bryan King, Gina M. Sizemore, Natalya N. Pavlova, Francesco V Cimino, Craig B. Thompson
Publikováno v:
Nature Metabolism. 3:1484-1499
The aberrant production of collagen by fibroblasts is a hallmark of many solid tumours and can influence cancer progression. How the mesenchymal cells in the tumour microenvironment maintain their production of extracellular matrix proteins as the va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b183b815342e07d4387b91e5000fabf3
https://doi.org/10.1038/s42255-021-00480-x
https://doi.org/10.1038/s42255-021-00480-x
Autor:
Urmi Bandyopadhyay, Pavlina Todorova, Natalya N. Pavlova, Yuma Tada, Craig B. Thompson, Lydia W.S. Finley, Michael Overholtzer
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Cells acquire essential nutrients from the environment and utilize adaptive mechanisms to survive when nutrients are scarce. How nutrients are trafficked and compartmentalized within cells and whether they are stored in response to stress remain poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4697f30c3224bb84055dffc0fd23db
https://doi.org/10.1073/pnas.2114912119
https://doi.org/10.1073/pnas.2114912119
Autor:
Sander M. Houten, Carmen Argmann, Natalya N. Pavlova, Aaron Bender, Brandon Stauffer, Pablo Ranea-Robles, Chunli Yu, Craig B. Thompson, Michelle Puchowicz
The heart relies mainly on mitochondrial fatty acid β-oxidation (FAO) for its high energy requirements. Cardiomyopathy and arrhythmias can be severe complications in patients with inherited defects in mitochondrial long-chain FAO, reinforcing the im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37fa253ccae014d55647ad80736b2dc5
https://doi.org/10.1101/2021.05.13.443905
https://doi.org/10.1101/2021.05.13.443905
Autor:
Simon, Schwörer, Natalya N, Pavlova, Francesco V, Cimino, Bryan, King, Xin, Cai, Gina M, Sizemore, Craig B, Thompson
Publikováno v:
Nature metabolism. 3(11)
The aberrant production of collagen by fibroblasts is a hallmark of many solid tumours and can influence cancer progression. How the mesenchymal cells in the tumour microenvironment maintain their production of extracellular matrix proteins as the va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb25f97455b83dbb6434106e25b64c05
https://pubmed.ncbi.nlm.nih.gov/34764457
https://pubmed.ncbi.nlm.nih.gov/34764457
Autor:
Natalya N Pavlova, Christian Pallasch, Andrew EH Elia, Christian J Braun, Thomas F Westbrook, Michael Hemann, Stephen J Elledge
Publikováno v:
eLife, Vol 2 (2013)
During all stages of tumor progression, cancer cells are subjected to inappropriate extracellular matrix environments and must undergo adaptive changes in order to evade growth constraints associated with the loss of matrix attachment. A gain of func
Externí odkaz:
https://doaj.org/article/35a1c62bb4604d2c8fecec3f358548ad