Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Natalya M. Kogan"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 100 (2024)
Glioblastoma multiforme (GBM) is the most common type of glioma, with a median survival of 14.6 months post-diagnosis. Understanding the molecular profile of such tumors allowed the development of specific targeted therapies toward GBM, with a major
Externí odkaz:
https://doaj.org/article/0c1e33cfdbe04fa9ab2d67173df208e6
Autor:
Natalya M. Kogan, Dilorom Begmatova, Liudmila Vinnikova, Sergey Malitsky, Maxim Itkin, Eyal Sharon, Artem Klinov, Jonathan Gorelick, Igor Koman, Zvi Vogel, Raphael Mechoulam, Albert Pinhasov
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Rationale: The endocannabinoid system is known to be involved in learning, memory, emotional processing and regulation of personality patterns. Here we assessed the endocannabinoid profile in the brains of mice with strong characteristics of social d
Externí odkaz:
https://doaj.org/article/4f4a983bb1e443faa2a911cf993a6958
Autor:
Chanchal Thomas Mannully, Reut Bruck-Haimson, Anish Zacharia, Paul Orih, Alaa Shehadeh, Daniel Saidemberg, Natalya M. Kogan, Sivan Alfandary, Raphael Serruya, Arie Dagan, Isabelle Petit, Arieh Moussaieff
Publikováno v:
Cell Death and Disease, Vol 13, Iss 12, Pp 1-11 (2022)
Abstract Stem cells are defined by their ability to self-renew and differentiate, both shown in multiple studies to be regulated by metabolic processes. To decipher metabolic signatures of self-renewal in blastocyst-derived stem cells, we compared ea
Externí odkaz:
https://doaj.org/article/1550bbce4530401f9f2e8726ddd2b069
Autor:
Danielle Hen-Shoval, Lital Moshe, Talia Indig-Naimer, Raphael Mechoulam, Gal Shoval, Gil Zalsman, Natalya M. Kogan, Aron Weller
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3828 (2023)
The pathophysiology of major depressive disorder (MDD) is diverse and multi-factorial, yet treatment strategies remain limited. While women are twice as likely to develop the disorder as men, many animal model studies of antidepressant response rely
Externí odkaz:
https://doaj.org/article/0c1d00d3f81c4d2e952867a0ed398bf0
Autor:
Natalya M. Kogan, Yarden Lavi, Louise M. Topping, Richard. O. Williams, Fiona E. McCann, Zhanna Yekhtin, Marc Feldmann, Ruth Gallily, Raphael Mechoulam
Publikováno v:
Molecules, Vol 26, Iss 18, p 5601 (2021)
Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to p
Externí odkaz:
https://doaj.org/article/a6ffb15a4ba14101a91c716db021ac58
Publikováno v:
Molecules, Vol 26, Iss 6, p 1761 (2021)
A cannabinoid anticancer para-quinone, HU-331, which was synthesized by our group five decades ago, was shown to have very high efficacy against human cancer cell lines in-vitro and against in-vivo grafts of human tumors in nude mice. The main mechan
Externí odkaz:
https://doaj.org/article/fabb0b4e507b4792bcf25278c22323b7
Autor:
Albert Batushansky, Anish Zacharia, Alaa Shehadeh, Reut Bruck-Haimson, Daniel Saidemberg, Natalya M. Kogan, Chanchal Thomas Mannully, Shmuel Herzberg, Assaf Ben-Meir, Arieh Moussaieff
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1135 (2020)
Follicular fluid (FF) constitutes the microenvironment of the developing oocyte. We recently characterized its lipid composition and found lipid signatures of positive pregnancy outcome after in vitro fertilization (IVF). In the current study, we aim
Externí odkaz:
https://doaj.org/article/a1d7995f236744a09b2f41e2afb3a777
Autor:
Bitya Raphael-Mizrahi, Malka Attar-Namdar, Mukesh Chourasia, Maria G Cascio, Avital Shurki, Joseph Tam, Moshe Neuman, Neta Rimmerman, Zvi Vogel, Arie Shteyer, Roger G Pertwee, Andreas Zimmer, Natalya M Kogan, Itai Bab, Yankel Gabet
Publikováno v:
eLife, Vol 11 (2022)
The endocannabinoid system consists mainly of 2-arachidonoylglycerol and anandamide, as well as cannabinoid receptor type 1 and type 2 (CB2). Based on previous studies, we hypothesized that a circulating peptide previously identified as osteogenic gr
Externí odkaz:
https://doaj.org/article/b1b065666f49413c8b2026a4bcaff88e
Autor:
Bitya Raphael-Mizrahi, Malka Attar-Namdar, Mukesh Chourasia, Maria G Cascio, Avital Shurki, Joseph Tam, Moshe Neuman, Neta Rimmerman, Zvi Vogel, Arie Shteyer, Roger G Pertwee, Andreas Zimmer, Natalya M Kogan, Itai Bab, Yankel Gabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24c5ecc3b06693d8e61eee26c040b598
https://doi.org/10.7554/elife.65834.sa2
https://doi.org/10.7554/elife.65834.sa2
Autor:
Avigail Zucker, Nir Goldstein, Alaa Shehadeh, Arieh Moussaieff, Daniel Saidemberg, Yulia Haim, Reut Sinai, Natalya M. Kogan, Reut Bruck-Haimson, Chanchal Thomas Mannully, Assaf Rudich, Anish Zacharia, Christian Dani
Publikováno v:
The American Journal of Clinical Nutrition
Background Adipose tissue plays important roles in health and disease. Given the unique association of visceral adipose tissue with obesity-related metabolic diseases, the distribution of lipids between the major fat depots located in subcutaneous an