Výsledky vyhledávání - "Natalya M Ananyeva"

Inhibitors in Hemophilia A: Advances in Elucidation of Inhibitory Mechanisms and in Inhibitor Management with Bypassing Agents

Autor: Natalya M Ananyeva, Timothy K Lee, Midori Shima, Nisha Jain, Evgueni L. Saenko

Publikováno v: Seminars in Thrombosis and Hemostasis. 35:735-751

Development of inhibitory antibodies (inhibitors) to factor VIII (FVIII) is the most serious adverse event in replacement therapy of hemophilia A patients. The etiology and management of this condition remain major challenges for both researchers and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53929822bb986233f4d5260d6c1ad7c
https://doi.org/10.1055/s-0029-1245106

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Mathematical Models of Blood Coagulation and Platelet Adhesion: Clinical Applications

Autor: Fazoil I. Ataullakhanov, Natalya M. Ananyeva, Mikhail A. Panteleev, Evgueni L. Saenko

Publikováno v: Current Pharmaceutical Design. 13:1457-1467

At present, computer-assisted molecular modeling and virtual screening have become effective and widely-used tools for drug design. However, a prerequisite for design and synthesis of a therapeutic agent is determination of a correct target in the me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f13b801f65306c68c1169a6b72a00faf
https://doi.org/10.2174/138161207780765936

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Localization of the low-density lipoprotein receptor-related protein regions involved in binding to the A2 domain of coagulation factor VIII

Autor: Alexey V. Khrenov, Dudley K. Strickland, Irina Mikhailenko, Evgueni L. Saenko, Olav M. Andersen, Midori Shima, Andrey G. Sarafanov, Natalya M. Ananyeva, Evgeny M. Makogonenko

Publikováno v: Thrombosis and Haemostasis. 98:1170-1181

SummaryCatabolism of coagulation factorVIII (FVIII) is mediated by lowdensity lipoprotein receptor-related protein (LRP). The ligandbinding sites of LRP are formed by complement-type repeats (CR), and CR clusters II and IV bind most of LRP ligands. F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44b458e2773912998bcde45268989329
https://doi.org/10.1160/th07-05-0353

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Receptor-mediated clearance of factor VIII: implications for pharmacokinetic studies in individuals with haemophilia

Autor: Natalya M. Ananyeva, Evgueni L. Saenko

Publikováno v: Haemophilia. 12:15-22

Summary The present review discusses the current concept of receptor-mediated clearance of coagulation factor VIII (FVIII) from the circulation in vivo, which is one of the mechanisms regulating FVIII level in plasma. Several lines of experimental ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95c223472ad475cc555efdcf2e440349
https://doi.org/10.1111/j.1365-2516.2006.01329.x

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Spatial Propagation and Localization of Blood Coagulation Are Regulated by Intrinsic and Protein C Pathways, Respectively

Autor: Dmitrii A. Kireev, Mikhail A. Panteleev, Evgueni L. Saenko, Natalya M. Ananyeva, Fazoil I. Ataullakhanov, Elena I. Sinauridze, Aleksei M. Shibeko, A. A. Butylin, Mikhail V Ovanesov

Publikováno v: Biophysical Journal. 90:1489-1500

Blood coagulation in vivo is a spatially nonuniform, multistage process: coagulation factors from plasma bind to tissue factor (TF)-expressing cells, become activated, dissociate, and diffuse into plasma to form enzymatic complexes on the membranes o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f0c2f0732a86140b1ec07a50a0ae1f
https://doi.org/10.1529/biophysj.105.069062

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Identification of Coagulation Factor VIII A2 Domain Residues Forming the Binding Epitope for Low-Density Lipoprotein Receptor-Related Protein

Autor: Klaus-Peter Radtke, Dudley K Strickland, Alexey V Khrenov, Evgeny M Makogonenko, Evgueni L Saenko, Andrey G Sarafanov, Igor Pechik, Natalya M Ananyeva

Publikováno v: Biochemistry. 45:1829-1840

Regulation of the coagulation factor VIII (fVIII) level in circulation involves a hepatic receptor low-density lipoprotein receptor-related protein (LRP). One of two major LRP binding sites in fVIII is located within the A2 domain (A2), likely expose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a9b22eab1523cdaef1f832d1143d98
https://doi.org/10.1021/bi0520380

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Factor VIIIa regulates substrate delivery to the intrinsic factor X-activating complex

Autor: Mikhail A. Panteleev, Fazoil I. Ataullakhanov, Evgueni L. Saenko, Nicholas J. Greco, Natalya M. Ananyeva

Publikováno v: FEBS Journal. 273:374-387

Activation of coagulation factor X (fX) by activated factors IX (fIXa) and VIII (fVIIIa) requires the assembly of the enzyme-cofactor-substrate fIXa-fVIIIa-fX complex on negatively charged phospholipid membranes. Using flow cytometry, we explored for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95195023f71fc393b0f223a369d1e5fa
https://doi.org/10.1111/j.1742-4658.2005.05070.x

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Initiation and propagation of coagulation from tissue factor‐bearing cell monolayers to plasma: initiator cells do not regulate spatial growth rate

Autor: Fazoil I. Ataullakhanov, Mikhail V Ovanesov, Natalya M. Ananyeva, Mikhail A. Panteleev, Evgueni L. Saenko

Publikováno v: Journal of Thrombosis and Haemostasis. 3:321-331

Exposure of tissue factor (TF)-bearing cells to blood is the initial event in coagulation and intravascular thrombus formation. However, the mechanisms which determine thrombus growth remain poorly understood. To explore whether the procoagulant acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d3d504c34e182b59677b9f7378caa9
https://doi.org/10.1111/j.1538-7836.2005.01128.x

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Treating haemophilia A with recombinant blood factors: a comparison

Autor: Natalya M. Ananyeva, Alexey V. Khrenov, Evgueni L. Saenko, Robert Summers, Andrey Sarafanov, Fred Darr

Publikováno v: Expert Opinion on Pharmacotherapy. 5:1061-1070

The mainstay in the treatment of haemophilia A is replacement therapy with repeated infusions of plasma-derived Factor VIII (FVIII) concentrates or recombinant FVIII products. While modern plasma-derived FVIII concentrates have an excellent safety pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d810c81eb5f2a98aa48b4ebc4fa52f
https://doi.org/10.1517/14656566.5.5.1061

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Inhibitors in hemophilia A

Autor: Midori Shima, Mikhail V Ovanesov, Alexey V. Khrenov, Natalya M. Ananyeva, Sébastien Lacroix-Desmazes, Charlotte A. E. Hauser, Evgueni L. Saenko

Publikováno v: Blood Coagulation & Fibrinolysis. 15:109-124

Factor VIII (FVIII) replacement therapy remains the mainstay in hemophilia A care. The major complication of replacement therapy is formation of antibodies, which inhibit FVIII activity, thus dramatically reducing treatment efficiency. The present re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e4801e719d0f10d0418bc95e594e52
https://doi.org/10.1097/00001721-200403000-00001

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