Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Natalya I. Vasilevich"'
Autor:
Natalya I. Vasilevich, Victor V. Tatarskiy, Elena A. Aksenova, Denis N. Kazyulkin, Ilya I. Afanasyev
Publikováno v:
Pharmaceuticals, Vol 9, Iss 2, p 19 (2016)
Based on the data for compounds known from the literature to be active against various types of Ser/Thr kinases, a general pharmachophore model for these types of kinases was developed. The search for the molecules fitting to this pharmacophore among
Externí odkaz:
https://doaj.org/article/e0ea096e19694f9398e19bfa0a5ce99b
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 1, Iss 1, p 9 (2005)
2-Aryl-6-cyano-7-methyl-5-indolizinones were successfully converted into 2-aryl-5-chloro-6-cyano-7-methylindolizines. The obtained 5-chloroindolizines readily underwent nucleophilic substitution at position 5 leading in high yields to novel 5-functio
Externí odkaz:
https://doaj.org/article/61d447511af3433f99844370a4916915
Autor:
KUNXIAN FENG, CHENGFANG JIAN, HAIHUA XIAO, HUANGYU JIANG, JINPING YANG, MENGLI YANG, ANDRE SUN, WENMING SONG, ALEXANDER V. CHESTKOV, NATALYA I. VASILEVICH, LICHUN SUN
Publikováno v:
Anticancer Research. 43:2609-2624
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8c47c70e3dfb16c00c50fcce69c235c
https://doi.org/10.21873/anticanres.16428
https://doi.org/10.21873/anticanres.16428
Autor:
D. A. Mavletova, Natalya I. Vasilevich, D. A. Maslov, Olga B. Bekker, Ilya I. Afanasyev, Valery N. Danilenko, L M Kniazeva, M. G. Alekseeva
Publikováno v:
Bulletin of Russian State Medical University. :38-43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09a00fa18591c4e5334eeac7eb6b1aef
https://doi.org/10.24075/brsmu.2017-01-04
https://doi.org/10.24075/brsmu.2017-01-04
Autor:
Michael Engsig, Natalya I. Vasilevich, Denis N. Kazyulkin, Ekaterina Vlasova, Oxana Yu. Kravtsova, Sergey A. Paramonov
Publikováno v:
Biomedical Chromatography. 27:1609-1614
A specific, sensitive, rapid and reproducible method for the determination of flomoxef in human plasma using high-performance liquid chromatography–tandem mass spectrometry was developed and validated. Flomoxef was detected using an electrospay ion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::635caf6255fdc6ae264126f625bd869c
https://doi.org/10.1002/bmc.2968
https://doi.org/10.1002/bmc.2968
Publikováno v:
Proceedings of 2nd International Electronic Conference on Medicinal Chemistry.
Based on an earlier suggested general pharnacophore approach, compounds active against tuberculosis virulent strain H37Rv were obtained. The main drawback of these compounds was an almost complete CYP 3A4 inhibition, which presumably could be overcom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa69bc5a431a3aee89d0fb455984e4d1
https://doi.org/10.3390/ecmc-2-a013
https://doi.org/10.3390/ecmc-2-a013
Autor:
Vladimir Zernov, Dmitry V. Genis, Michael A. Kirpichenok, Natalya I. Vasilevich, Zoya Titarenko
Publikováno v:
Journal of Computer-Aided Molecular Design. 27:125-160
An analysis of the chemical environment of the oxygen atoms in the DNP database compared to the CMC and SCD databases was performed. Some structural clusters were identified which are predominant among the natural products and can be considered as di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e71efbf282931c8b9e9d35ff2207acf
https://doi.org/10.1007/s10822-012-9629-z
https://doi.org/10.1007/s10822-012-9629-z
Publikováno v:
Journal of Medicinal Chemistry. 55:7003-7009
After several decades of decline in NPs research we haverecently seen a real explosion of interest in natural-basedcompounds. However, although many NPs have beensynthesized since the first total synthesis of urea (Wohler,1828), α-terpineol and cam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74a414406f1c6836f95993fc450d843e
https://doi.org/10.1021/jm300344v
https://doi.org/10.1021/jm300344v
Autor:
Nevena Mollova, Alexei V. Ivanov, Ian Henderson, Parkhill Eric Q, Jeffrey Chisholm, Kwan Leung, Andrew G. Cole, Sandra A. Brunn, Andrei Glushkov, Dmitry Koltun, Natalya I. Vasilevich, Nathan A. Zautke, Timur Zilbershtein, Jeff Zablocki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2048-2052
We identified a series of structurally novel SCD (Delta9 desaturase) inhibitors via high-throughput screening and follow-up SAR studies. Modification of the central bicyclic scaffold has proven key to our potency optimization effort. The most potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae47b61e32bb963232729ec6fd27d146
https://doi.org/10.1016/j.bmcl.2009.02.019
https://doi.org/10.1016/j.bmcl.2009.02.019
Publikováno v:
Proceedings of 1st International Electronic Conference on Medicinal Chemistry.
Based on the data of compounds known from the literature to be active against various types of Ser/Thr kinases a general pharmachophore model for these types of kinases was developed. Search for the molecules fitting to this pharmacophore among ASINE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef9ae50794b46710a0d3d861dfbc1688
https://doi.org/10.3390/ecmc-1-a036
https://doi.org/10.3390/ecmc-1-a036