Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Natallie, Kajevu"'
Autor:
Natallie Kajevu, Anssi Lipponen, Pedro Andrade, Ivette Bañuelos, Noora Puhakka, Elina Hämäläinen, Teemu Natunen, Mikko Hiltunen, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14049 (2023)
We tested a hypothesis that in silico-discovered compounds targeting traumatic brain injury (TBI)-induced transcriptomics dysregulations will mitigate TBI-induced molecular pathology and augment the effect of co-administered antiseizure treatment, th
Externí odkaz:
https://doaj.org/article/1f3bc2149fe249bdb536c8bf79bb03a8
Autor:
Anssi Lipponen, Natallie Kajevu, Teemu Natunen, Robert Ciszek, Noora Puhakka, Mikko Hiltunen, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 4116 (2023)
Analysis platforms to predict drug-induced seizure liability at an early phase of drug development would improve safety and reduce attrition and the high cost of drug development. We hypothesized that a drug-induced in vitro transcriptomics signature
Externí odkaz:
https://doaj.org/article/46ba25784dc24975adec02344f432ac5
Autor:
Jenni Kyyriäinen, Natallie Kajevu, Ivette Bañuelos, Leonardo Lara, Anssi Lipponen, Silvia Balosso, Elina Hämäläinen, Shalini Das Gupta, Noora Puhakka, Teemu Natunen, Teresa Ravizza, Annamaria Vezzani, Mikko Hiltunen, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10555 (2021)
We assessed the effect of antioxidant therapy using the Food and Drug Administration-approved respiratory drug N-acetylcysteine (NAC) or sulforaphane (SFN) as monotherapies or duotherapy in vitro in neuron-BV2 microglial co-cultures and validated the
Externí odkaz:
https://doaj.org/article/b998370c5ed947969d9f9c88922b1f47
Autor:
Clément Plaud, Vandana Joshi, Natallie Kajevu, Christian Poüs, Patrick A. Curmi, Andrea Burgo
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 9 (2018)
Mutations of the SPG4 (SPAST) gene encoding for spastin protein are the main causes of hereditary spastic paraplegia. Spastin binds to microtubules and severs them through the enzymatic activity of its AAA domain. Several missense mutations located i
Externí odkaz:
https://doaj.org/article/1b7d56e607844611aab32aec42576c21
Autor:
Robert Ciszek, Natallie Kajevu, Xavier Ekolle Ndode-Ekane, Jenni Kyyriäinen, Shalini Das Gupta, Mette Heiskanen, Tomi Paananen, Asla Pitkänen, Leonardo Lara-Valderrábano, Niina Lapinlampi, Niina Vuokila, Pedro Andrade, Noora Puhakka, Ivette Bañuelos-Cabrera
Publikováno v:
Epilepsybehavior : EB. 121
A biomarker is a characteristic that can be objectively measured as an indicator of normal biologic processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions. Biomarker modalities include molecu