Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Natalja Strelkowa"'
Autor:
Rainer Georg Goeldner, Li-Tzong Chen, Alan Anthoney, Karim Rihawi, Ann-Lii Cheng, Maria Jove, Susanne Buschke, Jesus Corral, Vasiliki Michalarea, Jih-Hsiang Lee, Thomas Bogenrieder, Her Shyong Shiah, René Fuertig, Michael Ong, Ulrike Schmid, Chia-Chi Lin, Dennis Chin-Lun Huang, Chih-Hung Hsu, Johann S. de Bono, James Chih-Hsin Yang, Chia Jui Yen, Chris Twelves, Natalja Strelkowa
Publikováno v:
British Journal of Cancer
Background Xentuzumab, an insulin-like growth factor (IGF)-1/IGF-2-neutralising antibody, binds IGF-1 and IGF-2, inhibiting their growth-promoting signalling. Two first-in-human trials assessed the maximum-tolerated/relevant biological dose (MTD/RBD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a29e29df9b254be8f87f8fcc43c3fad
Autor:
Rüdiger Koenen, Klaus Peter Kammerer, Kristell Marzin, Mabrouk Elgadi, Fenglei Huang, Natalja Strelkowa, Anne-Marie Quinson, Sebastian Haertter
Publikováno v:
The Journal of Clinical Pharmacology. 57:1305-1314
Faldaprevir (FDV) is a potent, orally administered inhibitor of hepatitis C virus protease. It inhibits multiple cytochrome P-450 enzymes and multiple membrane transporters. The objective of this study was to evaluate the effect of steady-state falda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::511013f139cb2c8bb00656fd358edd59
https://doi.org/10.1002/jcph.931
https://doi.org/10.1002/jcph.931
Autor:
Fenglei, Huang, Kristell, Marzin, Rüdiger, Koenen, Klaus Peter, Kammerer, Natalja, Strelkowa, Mabrouk, Elgadi, Anne-Marie, Quinson, Sebastian, Haertter
Publikováno v:
Journal of clinical pharmacology. 57(10)
Faldaprevir (FDV) is a potent, orally administered inhibitor of hepatitis C virus protease. It inhibits multiple cytochrome P-450 enzymes and multiple membrane transporters. The objective of this study was to evaluate the effect of steady-state falda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f94feaa39a538049c67cd236536f5fbe
https://pubmed.ncbi.nlm.nih.gov/28513969
https://pubmed.ncbi.nlm.nih.gov/28513969
Autor:
Fenglei Huang, Mabrouk Elgadi, Natalja Strelkowa, A. Schultz, Jeanette Garcia, Peter Rose, David Joseph
Publikováno v:
The Journal of Clinical Pharmacology. 55:384-391
Faldaprevir is a potent hepatitis C virus (HCV) NS3/4A protease inhibitor and an inhibitor of UDP-glucuronosyltransferase-1A1 (UGT1A1), which is involved in raltegravir clearance. Raltegravir, an HIV integrase inhibitor, may be used in combination wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00f46377416caff03641cfec14b2e6c
https://doi.org/10.1002/jcph.418
https://doi.org/10.1002/jcph.418
Autor:
Natalja Strelkowa, Michael Lässig
Publikováno v:
Genetics
The seasonal influenza A virus undergoes rapid evolution to escape human immune response. Adaptive changes occur primarily in antigenic epitopes, the antibody-binding domains of the viral hemagglutinin. This process involves recurrent selective sweep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91e330753875e8e98e5aa337f55c2eb
https://doi.org/10.1534/genetics.112.143396
https://doi.org/10.1534/genetics.112.143396
Autor:
Natalja Strelkowa, Mauricio Barahona
Publikováno v:
Journal of the Royal Society Interface
Ring topologies of repressing genes have qualitatively different long-term dynamics if the number of genes is odd (they oscillate) or even (they exhibit bistability). However, these attractors may not fully explain the observed behavior in transient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0c802ac592799c6713f6eaab9f6047
http://europepmc.org/articles/PMC2880078
http://europepmc.org/articles/PMC2880078
Autor:
Natalja Strelkowa
Publikováno v:
ISCS 2014: Interdisciplinary Symposium on Complex Systems ISBN: 9783319107585
Synthetic biology has impressively progressed during the last decades making it possible to rationally design and implement genetic networks with new functionalities in living microorganisms. With these new technologies the expression of genes can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fefac0ad766e0438657503f41f16db01
https://doi.org/10.1007/978-3-319-10759-2_28
https://doi.org/10.1007/978-3-319-10759-2_28
Autor:
Natalja Strelkowa
Publikováno v:
Emergence, Complexity and Computation ISBN: 9783642454370
In this chapter we present the application of control theoretical concepts to stochastic dynamical systems which are based on the current knowledge of genetic networks. We showcase the application of reinforcement learning algorithm inferring an opti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11af9fa6cbe26da9ed1ef411d79f1325
https://doi.org/10.1007/978-3-642-45438-7_26
https://doi.org/10.1007/978-3-642-45438-7_26
Autor:
Natalja Strelkowa
Publikováno v:
How Nature Works ISBN: 9783319002538
In this chapter we present selected mathematical methods used for the design of synthetic gene networks. We showcase the method applications on the generalized repressilator model which simplest special cases—a genetic switch and a genetic oscillat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eff508e7f3afd3f77e4292313abb4e36
https://doi.org/10.1007/978-3-319-00254-5_8
https://doi.org/10.1007/978-3-319-00254-5_8
Autor:
Natalja Strelkowa, Mauricio Barahona
Publikováno v:
AIP Conference Proceedings.
We explore the impact of low copy number noise on the onset and quality of oscillations in the generalized repressilator model with odd-number of elements. In our previous work [Strelkowa & Barahona, 2011] we applied deterministic complexity analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00c3f0d3aab88c65bb016ef761454e2
https://doi.org/10.1063/1.4756221
https://doi.org/10.1063/1.4756221