Výsledky vyhledávání - "Nataliya Tovbis-Shifrin"

Akademický článek

Conditional Deletion of Pdcd1 Identifies the Cell-Intrinsic Action of PD-1 on Functional CD8 T Cell Subsets for Antitumor Efficacy

Autor: Sukanya Raghavan, Nataliya Tovbis-Shifrin, Christina Kochel, Anandi Sawant, Marielle Mello, Manjiri Sathe, Wendy Blumenschein, Eric S. Muise, Alissa Chackerian, Elaine M. Pinheiro, Thomas W. Rosahl, Hervé Luche, Rene de Waal Malefyt

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Programmed cell death-1 (PD-1) blockade has a profound effect on the ability of the immune system to eliminate tumors, but many questions remain about the cell types involved and the underlying mechanisms of immune activation. To shed some light on t

Externí odkaz: https://doaj.org/article/72fd7ab5d05749e780b38e08a7d4a277

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Akademický článek

214 The KRASG12D(ON) covalent tricomplex inhibitor RM-044 increases tumor antigen presentation and TCR repertoire diversity to promote anti-tumor immunity in a preclinical model of KRASG12D mutant cancer

Autor: Nataliya Tovbis Shifrin, Marie Menard, Haley Courtney, Swetha Ganesh, Alice Kumamoto, Lillian Seu, Jacqueline AM Smith, Elsa Quintana

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/a5e51eab63604e868847c92607d0e712

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Abstract 3475: RMC-9805, a first-in-class, mutant-selective, covalent and orally bioavailable KRASG12D(ON) inhibitor, promotes cancer-associated neoantigen recognition and synergizes with immunotherapy in preclinical models

Autor: Marie J. Menard, Christopher Chow, Kevin Chen, Cristina Blaj, Nataliya Tovbis Shifrin, Haley Courtney, Nicole M. Nasholm, Anna Pham, Alice Kumamoto, Swetha Ganesh, James W. Evans, Lindsey Lawrence, Brian Vonmelchert, Amy C. Kwok-Parkhill, Jingjing Jiang, John E. Knox, Jacqueline Smith, Elsa Quintana

Publikováno v: Cancer Research. 83:3475-3475

Major epithelial tumors harboring the cancer driver KRASG12D, the most common oncogenic KRAS mutation1, remain an outstanding unmet medical need. While oncogenic RAS primarily promotes tumor progression through sustained cellular proliferation, there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf5c3042b72095f531831ffe7500fcd8
https://doi.org/10.1158/1538-7445.am2023-3475

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Abstract 2837: Dual inhibition of SHP2 and CDK4/6 leads to immunological memory and immune-mediated anti-tumor activity in a mouse syngeneic model of breast cancer

Autor: Neil Omaque, Jacqueline Smith, Mallika Singh, Nataliya Tovbis Shifrin, Elsa Quintana, Tram Nguyen, Grace J. Lee, Robert J. Nichols, Edward G. Lorenzana, Amira Belwafa

Publikováno v: Cancer Research. 80:2837-2837

Allosteric inhibition of the phosphatase SHP2, a key signaling node in the RAS pathway, is a novel, investigational therapeutic strategy for patients bearing tumors with specific oncogenic mutations in this pathway. SHP2 also participates in signal t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c936cc119170d0f13c671ec57e7e747
https://doi.org/10.1158/1538-7445.am2020-2837

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