Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Nataliya S. Myshakina"'
Publikováno v:
ACS Infect Dis
The ribonuclease H (RNH) activity of HIV-1 reverse transcriptase (RT) is essential for viral replication and can be a target for drug development. Yet, no RNH inhibitor to date has substantial antiviral activity to allow advancement into clinical dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3be545a248fb8002fbf85657924a65e
https://doi.org/10.1021/acsinfecdis.9b00300
https://doi.org/10.1021/acsinfecdis.9b00300
Autor:
Stefan G. Sarafianos, Nataliya S. Myshakina, Lena Miller, Jing Tang, Andrew D. Huber, Sanjeev Kumar V. Vernekar, Michael A. Parniak, Yue-Lei Chen, Zhengqiang Wang
Publikováno v:
European Journal of Medicinal Chemistry. 133:85-96
Human immunodeficiency virus (HIV) reverse transcriptase (RT) associated ribonuclease H (RNase H) remains the only virally encoded enzymatic function not clinically validated as an antiviral target. 2-Hydroxyisoquinoline-1,3-dione (HID) is known to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1eb2b16ed50f0f5d1a0d36a292b3f6
https://doi.org/10.1016/j.ejmech.2017.03.059
https://doi.org/10.1016/j.ejmech.2017.03.059
Autor:
I. B. L’vov, Vladimir V. Korochentsev, Vitaliy V. Vovna, Aleksandr A. Komissarov, Nataliya S. Myshakina
Publikováno v:
Journal of Molecular Structure. 1099:579-587
Using ultraviolet photoelectron spectroscopy and electron density functional theory (DFT), we investigated the electronic structure of the d8 complex acetylacetonate Ni(a≿а≿)2 and its NH, S and NCH2-substitutes: nickel bis(acetylacetoneiminate)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb72400ab2b80d9c213becbdf6bfbbcf
https://doi.org/10.1016/j.molstruc.2015.07.014
https://doi.org/10.1016/j.molstruc.2015.07.014
Autor:
David Punihaole, Ryan S. Jakubek, Nataliya S. Myshakina, Sanford A. Asher, Steven J. Geib, Elizabeth M. Dahlburg, Zhenmin Hong
Publikováno v:
The Journal of Physical Chemistry B. 119:3931-3939
We investigated the normal mode composition and the aqueous solvation dependence of the primary amide vibrations of propanamide. Infrared, normal Raman, and UV resonance Raman (UVRR) spectroscopy were applied in conjunction with density functional th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e4424b7bef2e3360d568f26211ac9d
https://doi.org/10.1021/jp511356u
https://doi.org/10.1021/jp511356u
Autor:
Jing Tang, Michael A. Parniak, Andrew D. Huber, Jayakanth Kankanala, Daniel J. Wilson, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang, Sanjeev Kumar V. Vernekar, Bulan Wu, Mary C. Casey, Nataliya S. Myshakina
Publikováno v:
Journal of medicinal chemistry. 60(12)
Human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated ribonuclease H (RNase H) remains the only virally encoded enzymatic function yet to be exploited as an antiviral target. One of the possible challenges may be that targeting HIV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd22982f1bb783f3936ea54894b30df8
https://pubmed.ncbi.nlm.nih.gov/28525279
https://pubmed.ncbi.nlm.nih.gov/28525279
Autor:
Tatiana V Ilina, Michael A. Parniak, Eddy Arnold, Daniel M. Himmel, William C. Ho, Alexander Van Ry, Nataliya S. Myshakina
Publikováno v:
Journal of Molecular Biology. 426:2617-2631
Human immunodeficiency virus (HIV) encodes four essential enzymes: protease, integrase, reverse transcriptase (RT)-associated DNA polymerase, and RT-associated ribonuclease H (RNase H). Current clinically approved anti-AIDS drugs target all HIV enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b4dc6790d23f416ebdae19842d79b6
https://doi.org/10.1016/j.jmb.2014.05.006
https://doi.org/10.1016/j.jmb.2014.05.006
Autor:
Rieko Ishima, Nataliya S. Myshakina, Martin T. Christen, Jinwoo Ahn, Michael A. Parniak, Lakshmi Menon
Publikováno v:
Chemical Biology & Drug Design. 80:706-716
HIV-1 reverse transcriptase (RT) has been an attractive target for the development of antiretroviral agents. Although this enzyme is bi-functional, having both DNA polymerase and ribonuclease H (RNH) activities, there is no clinically approved inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faab4a0de90a2ebaab0c686a2adb3143
https://doi.org/10.1111/cbdd.12010
https://doi.org/10.1111/cbdd.12010
Publikováno v:
The Journal of Physical Chemistry B. 112:11873-11877
The effect of hydrogen bonding on the amide group vibrational spectra has traditionally been rationalized by invoking a resonance model where hydrogen bonding impacts the amide functional group by stabilizing its [(-)O-C=NH (+)] structure over the [O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ecc88a2b1a792c6b908cc9defa32078
https://doi.org/10.1021/jp8057355
https://doi.org/10.1021/jp8057355
Autor:
Nataliya S. Myshakina, Tatiana V Ilina, Michael A. Parniak, Venkata Ramana Sirivolu, Sanjeev Kumar V. Vernekar, Zhengqiang Wang
3’-Azidothymidine (AZT) was the first approved antiviral for the treatment of human immunodeficiency virus (HIV). Reported efforts in clicking the 3’-azido group of AZT have not yielded 1,2,3-triazoles active against HIV or any other viruses. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0398dea2e11d802a19ce8827ec88493
https://europepmc.org/articles/PMC4027054/
https://europepmc.org/articles/PMC4027054/
Autor:
I. B. L’vov, Vitaliy I. Vovna, Vladimir V. Korochentsev, Nataliya S. Myshakina, Alexander A. Komissarov
Publikováno v:
Journal of Molecular Structure. 1104:96
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dda06bb3922303cb4a3fd263dbf07a17
https://doi.org/10.1016/j.molstruc.2015.10.005
https://doi.org/10.1016/j.molstruc.2015.10.005