Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Nataliya Miropolskaya"'
Autor:
Julia Svetlova, Ekaterina Knizhnik, Valentin Manuvera, Vyacheslav Severov, Dmitriy Shirokov, Ekaterina Grafskaia, Pavel Bobrovsky, Elena Matyugina, Anastasia Khandazhinskaya, Liubov Kozlovskaya, Nataliya Miropolskaya, Andrey Aralov, Yuri Khodarovich, Vladimir Tsvetkov, Sergey Kochetkov, Vassili Lazarev, Anna Varizhuk
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15281 (2022)
The life cycle of severe acute respiratory syndrome coronavirus 2 includes several steps that are supposedly mediated by liquid–liquid phase separation (LLPS) of the viral nucleocapsid protein (N) and genomic RNA. To facilitate the rational design
Externí odkaz:
https://doaj.org/article/5cdcef7386f24d11bf46f5df37ccfbf2
Autor:
Elizaveta O. Boldinova, Pratibha P. Ghodke, Sruthi Sudhakar, Vipin Kumar Mishra, Anna A. Manukyan, Nataliya Miropolskaya, Pushpangadan I. Pradeepkumar, Alena V. Makarova
Publikováno v:
ACS Chemical Biology. 17:3238-3250
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4003a0268cf00f09c92bad6187ed138
https://doi.org/10.1021/acschembio.2c00717
https://doi.org/10.1021/acschembio.2c00717
Autor:
Nataliya Miropolskaya, Maxim Kozlov, Ivan Petushkov, Maria Prostova, Danil Pupov, Daria Esyunina, Sergey Kochetkov, Andrey Kulbachinskiy
Publikováno v:
Biochimie.
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) is the key enzyme required for viral replication and mRNA synthesis. RdRp is one of the most conserved viral proteins and a promising target for antiviral drugs and inhibitors. At the same time, analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd540e75fe2793190d9c4e79f5c1ba23
https://pubmed.ncbi.nlm.nih.gov/36252889
https://pubmed.ncbi.nlm.nih.gov/36252889
Publikováno v:
Biochemical and Biophysical Research Communications. 523:165-170
Bacterial RNA polymerase (RNAP) relies on the same active site for RNA synthesis and co-transcriptional RNA proofreading. The intrinsic RNA proofreading activity of RNAP can be greatly stimulated by Gre factors, which bind within the secondary channe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbb56fd3615977619bea239552421a8
https://doi.org/10.1016/j.bbrc.2019.12.045
https://doi.org/10.1016/j.bbrc.2019.12.045
Publikováno v:
The Journal of biological chemistry. 298(7)
Bacterial RNA polymerase (RNAP) coordinates transcription with DNA repair and replication. Many RNAP mutations have pleiotropic phenotypes with profound effects on transcription-coupled processes. One class of RNAP mutations (rpo∗) has been shown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57736e26b5645de14d798843c0a4653d
https://pubmed.ncbi.nlm.nih.gov/35667439
https://pubmed.ncbi.nlm.nih.gov/35667439
Publikováno v:
Biochemical and Biophysical Research Communications. 495:110-115
Bacterial RNA polymerase (RNAP) is an RNA-synthesizing molecular machine and a target for antibiotics. In transcription, RNAP can interact with DNA sequence-specifically, during promoter recognition by the σ-containing holoenzyme, or nonspecifically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5c8e06fd3068801b42c9f7acb5868b
https://doi.org/10.1016/j.bbrc.2017.10.151
https://doi.org/10.1016/j.bbrc.2017.10.151
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Scientific Reports
Scientific Reports
Besides X-family DNA polymerases (first of all, Pol β) several other human DNA polymerases from Y- and A- families were shown to possess the dRP-lyase activity and could serve as backup polymerases in base excision repair (Pol ι, Rev1, Pol γ and P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879c3c987089d72a156fa46b34cc7d4a
http://link.springer.com/article/10.1038/s41598-017-10668-5
http://link.springer.com/article/10.1038/s41598-017-10668-5
Conserved functions of the trigger loop and Gre factors in RNA cleavage by bacterial RNA polymerases
Publikováno v:
Journal of Biological Chemistry. 292:6744-6752
RNA cleavage by RNA polymerase (RNAP) is the central step in co-transcriptional RNA proofreading. Bacterial RNAPs were proposed to rely on the same mobile element of the active site, the trigger loop (TL), for both nucleotide addition and RNA cleavag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453b5529f520893d0fa5ee3f3a8240dc
https://doi.org/10.1074/jbc.m116.766592
https://doi.org/10.1074/jbc.m116.766592
Autor:
L. V. Gening, Konstantin Y. Kazachenko, Alena V. Makarova, Nataliya Miropolskaya, Vyacheslav Z. Tarantul
Publikováno v:
DNA Repair. 50:77-82
Y-family DNA polymerase iota (Pol ι) possesses both DNA polymerase and dRP lyase activities and was suggested to be involved in DNA translesion synthesis and base excision repair in mammals. The 129 strain of mice and its derivatives have a natural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5e26e667448ffabb8e04aaab03448f
https://doi.org/10.1016/j.dnarep.2017.01.001
https://doi.org/10.1016/j.dnarep.2017.01.001
Publikováno v:
Biochemical and Biophysical Research Communications. 469:294-299
Promoter recognition by bacterial RNA polymerase (RNAP) is a multi-step process involving multiple protein-DNA interactions and several structural and kinetic intermediates which remain only partially characterized. We used single-stranded DNA aptame
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033e6fd67066779d58316e83b46cde14
https://doi.org/10.1016/j.bbrc.2015.11.100
https://doi.org/10.1016/j.bbrc.2015.11.100