Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Nataliya M. Samoshina"'
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Akademický článek
Fliposomes: pH-Sensitive Liposomes Containing a trans-2-morpholinocyclohexanol-Based Lipid That Performs a Conformational Flip and Triggers an Instant Cargo Release in Acidic Medium
Autor: Barbora Brazdova, Andreas H. Franz, Vyacheslav V. Samoshin, Xin Guo, Xin Liu, Nataliya M. Samoshina
Publikováno v: Pharmaceutics, Vol 3, Iss 3, Pp 379-405 (2011)
Incorporation of a pH-sensitive conformational switch into a lipid structure enables a drastic conformational flip upon protonation that disrupts the liposome membrane and causes rapid release of cargo specifically in areas of increased acidity. pH-s
Externí odkaz: https://doaj.org/article/4ec9019172cc4160a67f971f6d009779
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3
Fliposomes: trans-2-aminocyclohexanol-based amphiphiles as pH-sensitive conformational switches of liposome membrane - a structure-activity relationship study
Autor: Xin Guo, Nataliya M. Samoshina, Xin Liu, Vyacheslav V. Samoshin, Yu Zheng, Andreas H. Franz
Publikováno v: Chemistry and physics of lipids. 210
Recently developed lipids with the trans-2-aminocyclohexanol (TACH) moiety represent unique pH-sensitive conformational switches ("flipids") that can trigger the membrane of liposome-based drug delivery systems at lowered pH as seen in many pathologi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daab3e1094440c1a20767c75ae565296
https://pubmed.ncbi.nlm.nih.gov/29111431
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4
Thio-β-D-glucosides: Synthesis and Evaluation as Glycosidase Inhibitors and Activators
Autor: Irina A. Dotsenko, Nataliya M. Samoshina, Andrey V. Samoshin, Andreas H. Franz, Vyacheslav V. Samoshin
Publikováno v: International Journal of Carbohydrate Chemistry. 2014:1-8
Structurally simple 1-thio-β-D-glucopyranosides were synthesized and tested as potential inhibitors toward several fungal glycosidases from Aspergillus oryzae and Penicillium canescens. Significant selective inhibition was observed for α- and β-gl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ea0cc55dfe70a31f1432f290420199
https://doi.org/10.1155/2014/941059
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6
Fliposomes: pH-triggered conformational flip of newtrans-2-aminocyclohexanol-based amphiphiles causes instant cargo release in liposomes
Autor: Yu Zheng, Nataliya M. Samoshina, Andreas H. Franz, Xin Liu, Xin Guo, Vyacheslav V. Samoshin
Publikováno v: Journal of Liposome Research. 22:319-328
A new type of pH-sensitive liposomes (fliposomes) was designed based on the amphiphiles that are able to perform a pH-triggered conformational flip (flipids). This flip disrupts the liposome membrane and causes rapid release of the liposome cargo, sp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08316f43ad50fc01d1ee061d24a4b8f0
https://doi.org/10.3109/08982104.2012.698420
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7
Convenient synthesis of 5-aryl(alkyl)sulfanyl-1,10-phenanthrolines from 5,6-epoxy-5,6-dihydro-1,10-phenanthroline, and their activity towards fungal β-d-glycosidases
Autor: Vyacheslav V. Samoshin, Nataliya M. Samoshina, Irina A. Dotsenko, Matthew Curtis
Publikováno v: Tetrahedron. 67:7470-7478
A broad series of novel 5-aryl(alkyl)sulfanyl-1,10-phenanthrolines has been prepared by a new simple procedure: a treatment of the commercially available 5,6-epoxy-5,6-dihydro-1,10-phenanthroline with various thiols in the presence of a base. Other f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff0e774662705a20fb375237e349dd68
https://doi.org/10.1016/j.tet.2011.07.058
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8
Fliposomes: pH-Sensitive Liposomes Containing a trans-2-morpholinocyclohexanol-Based Lipid That Performs a Conformational Flip and Triggers an Instant Cargo Release in Acidic Medium
Autor: Andreas H. Franz, Barbora Brazdova, Xin Liu, Nataliya M. Samoshina, Vyacheslav V. Samoshin, Xin Guo
Publikováno v: Pharmaceutics, Vol 3, Iss 3, Pp 379-405 (2011)
Pharmaceutics; Volume 3; Issue 3; Pages: 379-405
Pharmaceutics
Incorporation of a pH-sensitive conformational switch into a lipid structure enables a drastic conformational flip upon protonation that disrupts the liposome membrane and causes rapid release of cargo specifically in areas of increased acidity. pH-s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21cd3443dff1bc8d2e45784a1e2d3a6b
http://www.mdpi.com/1999-4923/3/3/379/
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9
trans-2-Aminocyclohexanol-based amphiphiles as highly efficient helper lipids for gene delivery by lipoplexes
Autor: Yu Zheng, Xin Liu, Nataliya M. Samoshina, Vyacheslav V. Samoshin, Andreas H. Franz, Xin Guo
Publikováno v: Biochimica et biophysica acta. 1848(12)
Lipidic amphiphiles equipped with the trans-2-aminocyclohexanol (TACH) moiety are promising pH-sensitive conformational switches (“flipids”) that can trigger a lipid bilayer perturbation in response to increased acidity. Because pH-sensitivity wa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a10f834e9f96bb700417071bf1210c
https://pubmed.ncbi.nlm.nih.gov/26386397
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10
The Michaelis constants ratio for two substrates with a series of fungal (mould and yeast) β-galactosidases
Autor: Vyacheslav V. Samoshin, Nataliya M. Samoshina
Publikováno v: Enzyme and Microbial Technology. 36:239-251
A comparative analysis of kinetic data for fungal β-galactosidases has revealed that the ratio of Michaelis constants (MCR) with two substrates (lactose and o / p -nitrophenyl-β- d -galactopyranoside, NPG) is approximately constant for certain grou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecf6cfe44e817b5c1466e28eea0300c5
https://doi.org/10.1016/j.enzmictec.2004.07.011
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