Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nataliya Gorinski"'
Autor:
Britta Stapel, Ke Xiao, Nataliya Gorinski, Kevin Schmidt, Angelika Pfanne, Jan Fiedler, Imke Richter, Anna-Lena Vollbrecht, Thomas Thum, Kai G. Kahl, Evgeni Ponimaskin
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
ObjectiveMajor depressive disorder (MDD) constitutes a main risk factor for suicide. Suicide risk in psychiatric patients is primarily determined by often unreliable, self-reported information. We assessed serum levels of three microRNAs (miRNAs), pr
Externí odkaz:
https://doaj.org/article/f419f568ff3c48a281d74bb27711ec03
Autor:
Nataliya Gorinski, Monika Bijata, Sonal Prasad, Alexander Wirth, Dalia Abdel Galil, Andre Zeug, Daria Bazovkina, Elena Kondaurova, Elizabeth Kulikova, Tatiana Ilchibaeva, Monika Zareba-Koziol, Francesco Papaleo, Diego Scheggia, Gaga Kochlamazashvili, Alexander Dityatev, Ian Smyth, Adam Krzystyniak, Jakub Wlodarczyk, Diethelm W. Richter, Tatyana Strekalova, Stephan Sigrist, Claudia Bang, Lisa Hobuß, Jan Fiedler, Thomas Thum, Vladimir S. Naumenko, Ghanshyam Pandey, Evgeni Ponimaskin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Palmitoylation is a post translational modification that regulates GPCR activity. Here the authors show that palmitoylation of 5-HT1AR by the palmitoyltransferase enzyme ZDHHC21 contributes to depression-like behaviour in rodents and might be implica
Externí odkaz:
https://doaj.org/article/b7ca995a09f14264a865413198bdb889
Autor:
Cornelius Faber, Christa Hohoff, Nicole Kerkenberg, Christiane Schettler, Lydia Wachsmuth, Evgeni Ponimaskin, Juergen Brosius, Dalia Abdel Galil, Maximilian Wewer, Mykola Kravchenko, Boris V. Skryabin, Nataliya Gorinski, Jens Buschert, Ilona Schneider, Mingyue Zhang, Kari Lavinia vom Werth, Oliver Ambrée, Dominik Grotegerd, Weiqi Zhang
Publikováno v:
Brain Structure and Function. 224:2213-2230
The palmitoyl acyltransferase ZDHHC7 belongs to the DHHC family responsible for the covalent attachment of palmitic acid (palmitoylation) to target proteins. Among synaptic proteins, its main targets are sex steroid receptors such as the estrogen rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee757125bba8f5b826923337b99c620
https://doi.org/10.1007/s00429-019-01898-6
https://doi.org/10.1007/s00429-019-01898-6
Autor:
Alexander Wirth, Josephine Labus, Dalia Abdel Galil, Yvonne Schill, Silke Schmidt, Tania Bunke, Nataliya Gorinski, Norihiko Yokoi, Masaki Fukata, Evgeni Ponimaskin
Publikováno v:
Journal of Biological Chemistry. 298:102048
The small GTPase Cdc42 exists in the form of two alternatively spliced variants that are modified by hydrophobic chains: the ubiquitously expressed Cdc42-prenyl and a brain-specific isoform that can be palmitoylated, Cdc42-palm. Our previous work dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a7a9caf3727b87107268b7938581e8
https://doi.org/10.1016/j.jbc.2022.102048
https://doi.org/10.1016/j.jbc.2022.102048
Autor:
Simon Bennet Sonnenberg, Vladimir S. Naumenko, Daria Guseva, Christoph Göhr, Stephan C. Bischoff, Dalia Abdel Galil, Andre Zeug, Sophie Kristin Schade, Nataliya Gorinski, Jonah Rauer, Evgeni Ponimaskin
Publikováno v:
Journal of Cell Science. 134
Morphological remodeling of dendritic spines is critically involved in memory formation and depends on adhesion molecules. Serotonin receptors are also implicated in this remodeling, though the underlying mechanisms remain enigmatic. Here, we uncover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36ed5be1adc4115d6343cf25f2ec3e67
https://doi.org/10.1242/jcs.249193
https://doi.org/10.1242/jcs.249193
Autor:
Monika Bijata, Ewa Bączyńska, Franziska E. Müller, Krystian Bijata, Julia Masternak, Adam Krzystyniak, Bernadeta Szewczyk, Marcin Siwiec, Svitlana Antoniuk, Matylda Roszkowska, Izabela Figiel, Marta Magnowska, Krzysztof H. Olszyński, Agnieszka D. Wardak, Adam Hogendorf, Błażej Ruszczycki, Nataliya Gorinski, Josephine Labus, Tomasz Stępień, Sylwia Tarka, Andrzej J. Bojarski, Krzysztof Tokarski, Robert K. Filipkowski, Evgeni Ponimaskin, Jakub Wlodarczyk
Publikováno v:
Cell reports. 38(11)
Major depressive disorder is a complex disease resulting from aberrant synaptic plasticity that may be caused by abnormal serotonergic signaling. Using a combination of behavioral, biochemical, and imaging methods, we analyze 5-HT7R/MMP-9 signaling a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf1b61b0f6592bc2985d4a931a975dd
https://pubmed.ncbi.nlm.nih.gov/35294881
https://pubmed.ncbi.nlm.nih.gov/35294881
Autor:
Simon Bennet, Sonnenberg, Jonah, Rauer, Christoph, Göhr, Nataliya, Gorinski, Sophie Kristin, Schade, Dalia, Abdel Galil, Vladimir, Naumenko, André, Zeug, Stephan C, Bischoff, Evgeni, Ponimaskin, Daria, Guseva
Publikováno v:
Journal of cell science. 134(4)
Morphological remodeling of dendritic spines is critically involved in memory formation and depends on adhesion molecules. Serotonin receptors are also implicated in this remodeling, though the underlying mechanisms remain enigmatic. Here, we uncover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ade5a97268b3e4d305d148c095c5759
https://pubmed.ncbi.nlm.nih.gov/33536244
https://pubmed.ncbi.nlm.nih.gov/33536244
Autor:
Noëmi Gmahl, Nataliya Gorinski, Helge Frieling, Stefan Bleich, Britta Stapel, Mathias Rhein, Vanessa Preuss, Evgeni Ponimaskin, Kai G. Kahl, Denise Hilfiker-Kleiner
Introduction: In line with the monoamine hypothesis of major depressive disorder (MDD), the clinical efficacy of the selective serotonin reuptake inhibitor fluoxetine has classically been ascribed to central serotonin enhancing properties. Current re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef64fc3964b239ad6cf946c7c673065
Autor:
Christian T. Mayer, Christina Hesse, Rolf Müller, Sarah K. Tschirner, Nataliya Gorinski, Amrita Nandan, Luciana Berod, Stefanie Hagemann, Jochen Huehn, Wolf-Rainer Abraham, Tim Sparwasser, Christin Friedrich, Melanie Gohmert, Matthias Lochner, Jenny Freitag, Heike Bähre, Carla N. Castro, Evgeni Ponimaskin, Aline Sandouk, Kirsten Harmrolfs
Publikováno v:
Nature Medicine. 20:1327-1333
Interleukin-17 (IL-17)-secreting T cells of the T helper 17 (TH17) lineage play a pathogenic role in multiple inflammatory and autoimmune conditions and thus represent a highly attractive target for therapeutic intervention. We report that inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4265512c4ab071169d47e3277be0be9
https://doi.org/10.1038/nm.3704
https://doi.org/10.1038/nm.3704
Autor:
Evgeni Ponimaskin, Mikhail A. Filippov, Nataliya Gorinski, Ghanshyam N. Pandey, Chen Chen-Wacker, Yao-Wen Wu, Alexander Wirth
Publikováno v:
Biochemical journal 456(3), 311-322 (2013). doi:10.1042/BJ20130788
Cdc42 (cell division cycle 42) is a member of the Rho GTPase family which regulates a variety of cellular activities by controlling actin cytoskeleton and gene expression. Cdc42 is expressed in the form of two splice variants. The canonical Cdc42 iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42177a2081f3a2a86a2c8dd10d2951cd
https://doi.org/10.1042/bj20130788
https://doi.org/10.1042/bj20130788