Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior

Autor: Einav Wircer, Janna Blechman, Nataliya Borodovsky, Michael Tsoory, Ana Rita Nunes, Rui F Oliveira, Gil Levkowitz

Publikováno v: eLife, Vol 6 (2017)

Proper response to stress and social stimuli depends on orchestrated development of hypothalamic neuronal circuits. Here we address the effects of the developmental transcription factor orthopedia (Otp) on hypothalamic development and function. We sh

Externí odkaz: https://doaj.org/article/b6e460f8c13e4a35849493be7119cf13

Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior

Autor: Michael Tsoory, Gil Levkowitz, Nataliya Borodovsky, Janna Blechman, Einav Wircer, Ana Rita Nunes, Rui Filipe Oliveira

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
eLife, Vol 6 (2017)
eLife

Proper response to stress and social stimuli depends on orchestrated development of hypothalamic neuronal circuits. Here we address the effects of the developmental transcription factor orthopedia (Otp) on hypothalamic development and function. We sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5604a2ec1eb031351bc41b5e21e8710d

Neural protein Olig2 acts upstream of the transcriptional regulator sim1 to specify diencephalic dopaminergic neurons

Autor: Shani Frenkel, Tatyana Ponomaryov, Nataliya Borodovsky, Gil Levkowitz

Publikováno v: Developmental Dynamics. 238:826-834

Neural factors are expressed in neural progenitors and regulate neurogenesis and gliogenesis. Recent studies suggested that these factors are also involved in determining specific neuronal fates by regulating the expression of their target genes, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673f0b95bc3b7ee9d58445bd028938ee
https://doi.org/10.1002/dvdy.21894

Homeodomain protein otp and activity-dependent splicing modulate neuronal adaptation to stress

Autor: Maayan Tahor, Gil Levkowitz, Janna Blechman, Adriana Reuveny, William H. J. Norton, Joshua L. Bonkowsky, Yehezkel Sztainberg, Nataliya Borodovsky, Liat Amir-Zilberstein, Alon Chen, Laure Bally-Cuif

Publikováno v: Neuron
Neuron, Elsevier, 2012, 73 (2), pp.279-91. ⟨10.1016/j.neuron.2011.11.019⟩

International audience; Regulation of corticotropin-releasing hormone (CRH) activity is critical for the animal's adaptation to stressful challenges, and its dysregulation is associated with psychiatric disorders in humans. However, the molecular mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a06bbd5ce822c28ccef8e24f8fc78e4
https://hal.archives-ouvertes.fr/hal-00683605