Výsledky vyhledávání - "Nataliya Bohdan"

Akademický článek

Anti-Tumor Functions of Prelatent Antithrombin on Glioblastoma Multiforme Cells

Autor: Julia Peñas-Martínez, Ginés Luengo-Gil, Salvador Espín, Nataliya Bohdan, Carmen Ortega-Sabater, Maria Carmen Ródenas, David Zaragoza-Huesca, María José López-Andreo, Carme Plasencia, Vicente Vicente, Alberto Carmona-Bayonas, Irene Martínez-Martínez

Publikováno v: Biomedicines, Vol 9, Iss 5, p 523 (2021)

Antithrombin, the main physiological inhibitor of the coagulation cascade, exerts anti-tumor effects on glioblastoma multiforme cells. Antithrombin has different conformations: native, heparin-activated, prelatent, latent, and cleaved. The prelatent

Externí odkaz: https://doaj.org/article/c64fa4755e314cc7b1a0e322be8cebb6

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Akademický článek

Heparanase Activates Antithrombin through the Binding to Its Heparin Binding Site.

Autor: Nataliya Bohdan, Salvador Espín, Sonia Águila, Raúl Teruel-Montoya, Vicente Vicente, Javier Corral, Irene Martínez-Martínez

Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0157834 (2016)

Heparanase is an endoglycosidase that participates in morphogenesis, tissue repair, heparan sulphates turnover and immune response processes. It is over-expressed in tumor cells favoring the metastasis as it penetrates the endothelial layer that line

Externí odkaz: https://doaj.org/article/ddd25526f4214edaa561a03124a4c68d

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Differential miRNA expression profile and proteome in plasma exosomes from patients with paroxysmal nocturnal hemoglobinuria

Autor: Nuria García-Barberá, Irene Martínez-Martínez, Juan Carlos Espín, Salvador Espín, Jose Yuste, Raúl Teruel-Montoya, Constantino Martínez, Fernando Vallejo, Nataliya Bohdan, Ginés Luengo-Gil, Vicente Vicente

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports

Paroxysmal Nocturnal Hemoglobinuria (PNH) is a clonal disease of blood cells caused by the lack of glycosyl phosphatidyl inositol anchored proteins bound to the cell membrane. In consequence, erythrocytes lead to intravascular hemolysis upon compleme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec547101d09c0b8a23888d2ab520a25d
http://link.springer.com/article/10.1038/s41598-019-40453-5

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Anti-Tumor Functions of Prelatent Antithrombin on Glioblastoma Multiforme Cells

Autor: Carme Plasencia, Carmen Ortega-Sabater, David Zaragoza-Huesca, Julia Peñas-Martínez, Irene Martínez-Martínez, Maria Jose Lopez-Andreo, Ginés Luengo-Gil, Nataliya Bohdan, Vicente Vicente, Salvador Espín, Alberto Carmona-Bayonas, M.C. Rodenas

Publikováno v: Biomedicines
Volume 9
Issue 5
Biomedicines, Vol 9, Iss 523, p 523 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9f569305a11c835ac558b1e21f7e28

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N-glycosylation as a Tool to Study Antithrombin Secretion, Conformation, and Function

Autor: Vicente Vicente, Irene Martínez-Martínez, Ginés Luengo-Gil, Nataliya Bohdan, Sonia Aguila, Rosina Noto, M.C. Rodenas, María Eugenia de la Morena-Barrio, Julia Peñas, Mauro Manno, Salvador Espín, Javier Corral

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 516, p 516 (2021)
International journal of molecular sciences (Online) 22 (2021). doi:10.3390/ijms22020516
info:cnr-pdr/source/autori:Aguila, Sonia; Noto, Rosina; Luengo-Gil, Gines; Espin, Salvador; Bohdan, Nataliya; de la Morena-barrio, Maria Eugenia; Penas, Julia; Rodenas, Maria Carmen; Vicente, Vicente; Corral, Javier; Manno, Mauro; Martinez-Martinez, Irene/titolo:N-Glycosylation as a Tool to Study Antithrombin Secretion, Conformation, and Function/doi:10.3390%2Fijms22020516/rivista:International journal of molecular sciences (Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22
International Journal of Molecular Sciences
Volume 22
Issue 2

N-linked glycosylation is a crucial post-translational modification involved in protein folding, function, and clearance. N-linked glycosylation is also used therapeutically to enhance the half-lives of many proteins. Antithrombin, a serpin with four

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0778a7e251e016b379692df285cacb3
https://www.mdpi.com/1422-0067/22/2/516

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Antithrombin is incorporated into exosomes produced by antithrombin non-expressing cells

Autor: Julia Peñas-Martínez, Nataliya Bohdan, Álvaro García-Hernández, Vicente Vicente, Irene Martínez-Martínez, Salvador Espín, Carmen Ortega-Sabater, Ginés Luengo-Gil, Antonio Bernardino García-Andreo, Elena Martínez-Planes, Miguel Quintanilla

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Antithrombin is a serine protease inhibitor that exerts a crucial role in hemostasis as the main inhibitor of the coagulation cascade. It plays also critical roles in other processes, such as inflammation and cancer. Here we show that exosomes releas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f591f4673d0521f605b5164f1eaf8da
http://hdl.handle.net/10261/206302

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First exploratory study on the metabolome from plasma exosomes in patients with paroxysmal nocturnal hemoglobinuria

Autor: Juan Carlos Espín, Nataliya Bohdan, Nuria García-Barberá, Vicente Vicente, Salvador Espín, Ginés Luengo-Gil, Constantino Martínez, Fernando Vallejo, Jose Yuste, Raúl Teruel-Montoya, Irene Martínez-Martínez

Publikováno v: Thrombosis research. 183

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease in which patients are at increased risk of thrombosis. The mechanisms underlying the associated thrombosis risk are still poorly understood, although it is known that Eculizumab, the drug of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b57fa7a5014153ee88417e97442c5ec
https://pubmed.ncbi.nlm.nih.gov/31671376

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Identification of a new potential mechanism responsible for severe bleeding in myeloma: immunoglobulins bind the heparin binding domain of antithrombin activating this endogenous anticoagulant

Autor: Fernando J. Corrales, Irene Martínez-Martínez, Nataliya Bohdan, Vicente Vicente, Salvador Espín, Felipe de Arriba, José Ramón González-Porras, Javier Corral, María José Cebeira

Publikováno v: Haematologica. 101:e423-e426

Bleeding is a relatively common complication in patients with multiple myeloma. Different factors have been involved, such as heparin-like anticoagulants, although the underlying mechanism remains obscure. The identification of a patient with a quies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddc29718e8b32aaef4ef7a79f1664e5
https://doi.org/10.3324/haematol.2016.144873

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Biochemical and cellular consequences of the antithrombin p.Met1? mutation identified in a severe thrombophilic family

Autor: José Navarro-Fernández, Mara Toderici, Ulrich Abildgaard, Antonia Miñano, Ingunn Dybedal, Vicente Vicente, Ketil Heimdal, María Eugenia de la Morena-Barrio, Javier Corral, José A. Martínez-Menárguez, Nataliya Bohdan, Emma Martínez-Alonso

Publikováno v: Oncotarget. 9(69)

// Jose Navarro-Fernandez 1, * , Maria Eugenia de la Morena-Barrio 1, * , Emma Martinez-Alonso 2 , Ingunn Dybedal 3 , Mara Toderici 1 , Nataliya Bohdan 1 , Antonia Minano 1 , Ketil Heimdal 4 , Ulrich Abildgaard 3 , Jose Angel Martinez-Menarguez 2 , J

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46876fbe64c4297097c4c278e523e7f8
https://pubmed.ncbi.nlm.nih.gov/30237862

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