Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Natalina Elliott"'
Autor:
Rebecca Ling, Thomas Jackson, Natalina Elliott, Joe Cross, Siobhan Rice, Rebecca Howitt, Alastair Smith, Joe Harman, Nicholas T Crump, Guanlin Wang, Deena Iskander, Supat Thongjuea, Philip Ancliff, Beth Psaila, Irene Roberts, Thomas Milne, Anindita Roy
Publikováno v:
HemaSphere, Vol 7, p e5649016 (2023)
Externí odkaz:
https://doaj.org/article/1a70baf48b1c4f12bacb34bdd6ceaaeb
Autor:
Siobhan Rice, Thomas Jackson, Nicholas T. Crump, Nicholas Fordham, Natalina Elliott, Sorcha O’Byrne, Maria del Mar Lara Fanego, Dilys Addy, Trisevgeni Crabb, Carryl Dryden, Sarah Inglott, Dariusz Ladon, Gary Wright, Jack Bartram, Philip Ancliff, Adam J. Mead, Christina Halsey, Irene Roberts, Thomas A. Milne, Anindita Roy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
It is unknown why infant acute lymphoblastic leukemia (ALL) produced by MLL rearrangements leads to worse outcomes than childhood ALL. Here the authors develop a CRISPR-Cas9-induced human xenograft model of MLL-AF4 infant-ALL that faithfully replicat
Externí odkaz:
https://doaj.org/article/7b0a760f1ba94c9d84a8eed3c5f42396
Autor:
Anindita Roy, Guanlin Wang, Deena Iskander, Sorcha O’Byrne, Natalina Elliott, Jennifer O’Sullivan, Gemma Buck, Elisabeth F. Heuston, Wei Xiong Wen, Alba Rodriguez Meira, Peng Hua, Anastasios Karadimitris, Adam J. Mead, David M. Bodine, Irene Roberts, Bethan Psaila, Supat Thongjuea
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109698- (2021)
Summary: Human hematopoiesis is a dynamic process that starts in utero 18–21 days post-conception. Understanding the site- and stage-specific variation in hematopoiesis is important if we are to understand the origin of hematological disorders, man
Externí odkaz:
https://doaj.org/article/9d0c2134b4a34cc79ac5a40723153498
Autor:
Stephen Smith, Rati Tripathi, Charnise Goodings, Susan Cleveland, Elizabeth Mathias, J Andrew Hardaway, Natalina Elliott, Yajun Yi, Xi Chen, James Downing, Charles Mullighan, Deborah A Swing, Lino Tessarollo, Liqi Li, Paul Love, Nancy A Jenkins, Neal G Copeland, Mary Ann Thompson, Yang Du, Utpal P Davé
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85883 (2014)
The LMO2 oncogene is deregulated in the majority of human T-cell leukemia cases and in most gene therapy-induced T-cell leukemias. We made transgenic mice with enforced expression of Lmo2 in T-cells by the CD2 promoter/enhancer. These transgenic mice
Externí odkaz:
https://doaj.org/article/21c934cd035a404580d328b1c317cbed
Autor:
Abdullah Khan, Antonio Rodriguez-Romera, Michela Colombo, Jasmeet S Reyat, Guanlin Wang, Wei Xiong Wen, Lauren C Murphy, Rebecca Ling, Natalina Elliott, Nikolaos Sousos, Samuel Kemble, Beata Grygielska, Christopher Mahoney, Andrew P. Stone, Adam P Croft, David Bassett, Gowsihan Poologasundarampillai, Adele K. Fielding, Emily A. Cutler, Anindita Roy, Sarah Gooding, Julie Rayes, Kellie Machlus, Bethan Psaila
Publikováno v:
Blood. 140:1679-1681
Autor:
Keren Xu, Shaobo Li, Ivo S. Muskens, Natalina Elliott, Swe Swe Myint, Priyatama Pandey, Helen M. Hansen, Libby M. Morimoto, Alice Y. Kang, Xiaomei Ma, Catherine Metayer, Beth A. Mueller, Irene Roberts, Kyle M. Walsh, Steve Horvath, Joseph L. Wiemels, Adam J. de Smith
Publikováno v:
Aging cell, vol 21, iss 7
Accelerated aging is a hallmark of Down syndrome (DS), with adults experiencing early-onset Alzheimer's disease and premature aging of the skin, hair, and immune and endocrine systems. Accelerated epigenetic aging has been found in the blood and brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f071565a107059953773a95d8a7c74
https://ora.ox.ac.uk/objects/uuid:c2e2f9d2-5afa-4bfb-9498-460e8b1c54f7
https://ora.ox.ac.uk/objects/uuid:c2e2f9d2-5afa-4bfb-9498-460e8b1c54f7
Autor:
Adam J. Mead, Jack Bartram, Natalina Elliott, Anindita Roy, Carryl Dryden, Christina Halsey, Siobhan Rice, Trisevgeni Crabb, Irene Roberts, Dilys Addy, Sorcha O’Byrne, Nicholas T. Crump, Nicholas Fordham, Gary Wright, Thomas Jackson, Dariusz Ladon, Thomas A. Milne, Philip Ancliff, Maria del Mar Lara Fanego, Sarah Inglott
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Although 90% of children with acute lymphoblastic leukemia (ALL) are now cured, the prognosis for infant-ALL remains dismal. Infant-ALL is usually caused by a single genetic hit that arises in utero: an MLL/KMT2A gene rearrangement (MLL-r). This is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f482cb0c7edcfa62aa38988a44fec1d
https://eprints.gla.ac.uk/258628/1/258628.pdf
https://eprints.gla.ac.uk/258628/1/258628.pdf
Autor:
Nicola K. Wilson, Michal Slyper, David Dixon, Gary Reynolds, Emily Stephenson, Berthold Göttgens, Irene Roberts, Petra Balogh, Anindita Roy, Bo Li, Monika S. Kowalczyk, Aviv Regev, Nicole Mende, Hamish W King, Iwo Kucinski, Laura Jardine, Mirjana Efremova, Meghan Acres, Orr Ashenberg, Caroline Shrubsole, Thomas Creasey, Dave Horsfall, Mika Sarkin Jain, Simone Webb, Elizabeth Poyner, Steven Lisgo, Rachel Queen, Kerstin B. Meyer, Kirsty Ambridge, John E. Lawrence, Natalina Elliott, Elena Prigmore, Jaume Bacardit, Rachel A. Botting, Danielle Dionne, Muzlifah Haniffa, Justin Engelbert, Marcin Tabaka, Rafiqul Hussain, Myriam L. R. Haltalli, Christopher D. Carey, Thomas Ness, Bayanne Olabi, Deborah J. Henderson, Daniel Maunder, Elisa Laurenti, Keir Pickard, Orit Rozenblatt-Rosen, Rowen Coulthard, Jim McGrath, Sam Behjati, Issac Goh, David McDonald, Sorcha O’Byrne, Timothy L. Tickle, Emma Dann, Claire G. Jones, Sarah A. Teichmann, Caitlin Murnane, Dorin-Mirel Popescu, Jonathan Coxhead, Mariana Quiroga Londoño, Michael W. Mather, Andrew Filby
Publikováno v:
Nature
Haematopoiesis in the bone marrow (BM) maintains blood and immune cell production throughout postnatal life. Haematopoiesis first emerges in human BM at 11–12 weeks after conception1,2, yet almost nothing is known about how fetal BM (FBM) evolves t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616a4b608e777594fb92efca1fe30968
https://doi.org/10.1038/s41586-021-03929-x
https://doi.org/10.1038/s41586-021-03929-x
Autor:
Justin Engelbert, Elisa Laurenti, Mirjana Efremova, Danielle Dionne, Dave Horsfall, John E. Lawrence, Nicola K. Wilson, Simone Webb, Michal Slyper, David Dixon, Berthold Göttgens, Elizabeth Poyner, Emma Dann, Orit Rozenblatt-Rosen, Nicole Mende, Steven Lisgo, Petra Balogh, Irene Roberts, Caitlin Murnane, Kerstin B. Meyer, Hamish W King, Emily Stephenson, Thomas Ness, Dorin-Mirel Popescu, Aviv Regev, Bayanne Olabi, Monika S. Kowalczyk, Marcin Tabaka, Laura Jardine, Gary Reynolds, Meghan Acres, Michael W. Mather, Anindita Roy, Rafiqul Hussain, Rowan Coulthard, Mika Sarkin Jain, Thomas Creasey, Kirsty Ambridge, Mariana Quiroga Londoño, Jonathan Coxhead, Christopher D. Carey, Timothy L. Tickle, Rachel A. Botting, Iwo Kucinski, Claire G. Jones, Andrew Filby, Daniel Maunder, Issac Goh, Keir Pickard, Rachel Queen, Sarah A. Teichmann, Elena Prigmore, Jim McGrath, Sorcha O’Byrne, Bo Li, Muzlifah Haniffa, Jaume Bacardit, David McDonald, Orr Ashenberg, Caroline Shrubsole, Natalina Elliott, Myriam L. R. Haltalli, Deborah J. Henderson, Sam Behjati
Throughout postnatal life, haematopoiesis in the bone marrow (BM) maintains blood and immune cell production. Haematopoiesis first emerges in human BM at 12 post conception weeks while fetal liver (FL) haematopoiesis is still expanding. Yet, almost n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a68bc8f664cc594c93c3bf6f0522e50
https://doi.org/10.1101/2021.06.25.449771
https://doi.org/10.1101/2021.06.25.449771
Autor:
Natalina Elliott, Alba Rodriguez-Meira, Sorcha O’Byrne, Deena Iskander, Ruggiero Norfo, Neil Ashley, Wei Xiong Wen, Anindita Roy, Nicholas Fordham, Booth Cag., Supat Thongjuea, E Louka, Benjamin J. Povinelli, Angela Hamblin, Irene Roberts, J de la Fuente, Mariolina Salio, Adam J. Mead, Georgina Buck, Anupama Rao, Sarah Inglott, Guanlin Wang, Nikolaos Sousos
Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually caused by RAS-pathway mutations. The cellular hierarchy in JMML is poorly characterized, including the identity of leukemia stem cells (LSCs). FACS and single-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c5520ffc57e856d193aa64ba4c8b40
https://hdl.handle.net/11380/1292009
https://hdl.handle.net/11380/1292009