Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Natalie de Geest"'
Autor:
Irene Talon, Adrian Janiszewski, Bart Theeuwes, Thomas Lefevre, Juan Song, Greet Bervoets, Lotte Vanheer, Natalie De Geest, Suresh Poovathingal, Ryan Allsop, Jean-Christophe Marine, Florian Rambow, Thierry Voet, Vincent Pasque
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-36 (2021)
Abstract Background Precise gene dosage of the X chromosomes is critical for normal development and cellular function. In mice, XX female somatic cells show transcriptional X chromosome upregulation of their single active X chromosome, while the othe
Externí odkaz:
https://doaj.org/article/553698c5364b4b4abcd02d2908aac7a2
Autor:
Juan Song, Adrian Janiszewski, Natalie De Geest, Lotte Vanheer, Irene Talon, Mouna El Bakkali, Taeho Oh, Vincent Pasque
Publikováno v:
Stem Cell Reports, Vol 12, Iss 2, Pp 333-350 (2019)
Summary: Reprogramming female mouse somatic cells into induced pluripotent stem cells (iPSCs) leads to X-chromosome reactivation. The extent to which increased X-chromosome dosage (X-dosage) in female iPSCs compared with male iPSCs leads to differenc
Externí odkaz:
https://doaj.org/article/3777719fc3bf4a5dad7402a043ebd6b8
Autor:
Marta Koch, Maya Nicolas, Marlen Zschaetzsch, Natalie de Geest, Annelies Claeys, Jiekun Yan, Matthew J. Morgan, Maria-Luise Erfurth, Matthew Holt, Dietmar Schmucker, Bassem A. Hassan
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2018)
Injury to the adult central nervous systems (CNS) can result in severe long-term disability because damaged CNS connections fail to regenerate after trauma. Identification of regulators that enhance the intrinsic growth capacity of severed axons is a
Externí odkaz:
https://doaj.org/article/8cf8885497d447a4a2c78e569f59525b
Autor:
Simon Weinberger, Matthew P Topping, Jiekun Yan, Annelies Claeys, Natalie De Geest, Duru Ozbay, Talah Hassan, Xiaoli He, Joerg T Albert, Bassem A Hassan, Ariane Ramaekers
Publikováno v:
eLife, Vol 6 (2017)
Animals are characterized by a set of highly conserved developmental regulators. Changes in the cis-regulatory elements of these regulators are thought to constitute the major driver of morphological evolution. However, the role of coding sequence ev
Externí odkaz:
https://doaj.org/article/199375c1820145b58b15d9f19d50a00a
Regulation of branching dynamics by axon-intrinsic asymmetries in Tyrosine Kinase Receptor signaling
Autor:
Marlen Zschätzsch, Carlos Oliva, Marion Langen, Natalie De Geest, Mehmet Neset Özel, W Ryan Williamson, William C Lemon, Alessia Soldano, Sebastian Munck, P Robin Hiesinger, Natalia Sanchez-Soriano, Bassem A Hassan
Publikováno v:
eLife, Vol 3 (2014)
Axonal branching allows a neuron to connect to several targets, increasing neuronal circuit complexity. While axonal branching is well described, the mechanisms that control it remain largely unknown. We find that in the Drosophila CNS branches devel
Externí odkaz:
https://doaj.org/article/a438c93848584e60b9de01501cf0ad54
Autor:
Marion Langen, Marta Koch, Jiekun Yan, Natalie De Geest, Maria-Luise Erfurth, Barret D Pfeiffer, Dietmar Schmucker, Yves Moreau, Bassem A Hassan
Publikováno v:
eLife, Vol 2 (2013)
Brain connectivity maps display a delicate balance between individual variation and stereotypy, suggesting the existence of dedicated mechanisms that simultaneously permit and limit individual variation. We show that during the development of the Dro
Externí odkaz:
https://doaj.org/article/258d5181d118405eb0d694e1b6c5a305
Autor:
Wouter Bossuyt, Natalie De Geest, Stein Aerts, Iris Leenaerts, Peter Marynen, Bassem A Hassan
Publikováno v:
PLoS Biology, Vol 7, Iss 2, p e40 (2009)
The acquisition of terminal cell fate and onset of differentiation are instructed by cell type-specific master control genes. Loss of differentiation is frequently observed during cancer progression, but the underlying causes and mechanisms remain po
Externí odkaz:
https://doaj.org/article/d936a21983004c358a11167c18610198
Autor:
Wouter Bossuyt, Avedis Kazanjian, Natalie De Geest, Sofie Van Kelst, Gert De Hertogh, Karel Geboes, Greg P Boivin, Judith Luciani, Francois Fuks, Marinee Chuah, Thierry VandenDriessche, Peter Marynen, Jan Cools, Noah F Shroyer, Bassem A Hassan
Publikováno v:
PLoS Biology, Vol 7, Iss 2, p e39 (2009)
Colon cancer accounts for more than 10% of all cancer deaths annually. Our genetic evidence from Drosophila and previous in vitro studies of mammalian Atonal homolog 1 (Atoh1, also called Math1 or Hath1) suggest an anti-oncogenic function for the Ato
Externí odkaz:
https://doaj.org/article/fb9b56ff2e344a0b8af06bba6b4c590a
Autor:
Nele Kindt, Geert Reyns, Olivier Defert, Patrick Schöffski, Massimiliano Mazzone, Agnieszka Wozniak, Carla Riera-Domingo, Marjan Diricx, Marijke Pellens, Tom Janssens, Marzia De Petrini, Natalie De Geest, Peter Pokreisz, Britt Van Renterghem, Lawrence Van Helleputte, Andrea Casazza
Clinical use of doxorubicin (Dox) is limited by cumulative myelo- and cardiotoxicity. This research focuses on the detailed characterization of PhAc-ALGP-Dox, a targeted tetrapeptide prodrug with a unique dual-step activation mechanism, designed to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8914754f35dc5e01e0cb964ae25c0fda
https://doi.org/10.1158/1535-7163.c.6543549
https://doi.org/10.1158/1535-7163.c.6543549
Autor:
Vincent Pasque, Tatsuya Yamakawa, Sophie Petropoulos, Irene Talon, Alexander Murray, Isidora Rovic, Janet Rossant, John P. Schell, Brian Bradshaw, San Kit To, Fredrik Lanner, Eszter Posfai, Pankaj Kumar, Tine Pardon, Mouna El Bakkali, Andrea Jurisicova, Adrian Janiszewski, Natalie De Geest
Publikováno v:
Nature Cell Biology. 23:49-60
Totipotency is the ability of a single cell to give rise to all of the differentiated cell types that build the conceptus, yet how to capture this property in vitro remains incompletely understood. Defining totipotency relies on a variety of assays o