Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Natalie Z.M. Homer"'
Autor:
Yang Luo, Laurent Chatre, Shaden Melhem, Zayana M. Al-Dahmani, Natalie Z.M. Homer, Anneke Miedema, Leo E. Deelman, Matthew R. Groves, Martin Feelisch, Nicholas M. Morton, Amalia Dolga, Harry van Goor
Publikováno v:
Redox Biology, Vol 68, Iss , Pp 102965- (2023)
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1) was discovered as an enzyme that detoxifies cyanide by conversion to thiocyanate (rhodanide) using thiosulfate as substrate; this rhodanese activity was subsequently identified to be almost exclusively
Externí odkaz:
https://doaj.org/article/60a049bd7a644081bdd281cc51e743d3
Autor:
Alastair J. Hayes, Xiaozhong Zheng, James O’Kelly, Lucile P.A. Neyton, Natalia A. Bochkina, Iain Uings, John Liddle, J. Kenneth Baillie, George Just, Margaret Binnie, Natalie Z.M. Homer, Toby B.J. Murray, James Baily, Kris McGuire, Christos Skouras, O. James Garden, Scott P. Webster, John P. Iredale, Sarah E.M. Howie, Damian J. Mole
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112763- (2023)
Summary: Kynurenine monooxygenase (KMO) blockade protects against multiple organ failure caused by acute pancreatitis (AP), but the link between KMO and systemic inflammation has eluded discovery until now. Here, we show that the KMO product 3-hydrox
Externí odkaz:
https://doaj.org/article/60fcd40d031a4ce4a162a97e4de568a3
Autor:
Rachel M.B. Bell, Elisa Villalobos, Mark Nixon, Allende Miguelez-Crespo, Lee Murphy, Angie Fawkes, Audrey Coutts, Matthew G.F. Sharp, Martha V. Koerner, Emma Allan, Onno C. Meijer, Renè Houtman, Alex Odermatt, Katharina R. Beck, Scott G. Denham, Patricia Lee, Natalie Z.M. Homer, Brian R. Walker, Ruth A. Morgan
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101225- (2021)
Objective: Carbonyl reductase 1 (Cbr1), a recently discovered contributor to tissue glucocorticoid metabolism converting corticosterone to 20β-dihydrocorticosterone (20β-DHB), is upregulated in adipose tissue of obese humans and mice and may contri
Externí odkaz:
https://doaj.org/article/a6432528238548eaaf19f70db5178bdf
Autor:
Rohit Sinha, Khalida A. Lockman, Natalie Z.M. Homer, Edward Bower, Paul Brinkman, Hugo H. Knobel, Jonathan A. Fallowfield, Alan J. Jaap, Peter C. Hayes, John N. Plevris
Publikováno v:
JHEP Reports, Vol 2, Iss 5, Pp 100137- (2020)
Background & aims: Analysis of volatile organic compounds (VOCs) in exhaled breath, ‘volatomics’, provides opportunities for non-invasive biomarker discovery and novel mechanistic insights into a variety of diseases. The purpose of this pilot stu
Externí odkaz:
https://doaj.org/article/c9945b053a8640cda085b65b0ee5ede1
Autor:
Nina Denver, Natalie Z.M. Homer, Ruth Andrew, Katie Y. Harvey, Nicholas Morrell, Eric D. Austin, Margaret R. MacLean
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Increased risk and severity of idiopathic pulmonary arterial hypertension (iPAH) is associated with elevated estradiol in men and postmenopausal women. Pulmonary arteries synthesise estradiol via aromatase and metabolise it via CYP1B1 to mitogenic me
Externí odkaz:
https://doaj.org/article/59a9d1e549ce4bb4a4d9563178b30633
Autor:
Nina Denver, Shazia Khan, Ioannis Stasinopoulos, Colin Church, Natalie Z.M. Homer, Margaret R. MacLean, Ruth Andrew
Publikováno v:
Data in Brief, Vol 23, Iss , Pp - (2019)
Analysis of catechol estrogens (2 & 4 hydroxy-estrone and estradiol) has proven troublesome by liquid chromatography tandem mass spectrometry due to their low concentrations, short half-lives and temperature-labile nature. Derivatization to methyl pi
Externí odkaz:
https://doaj.org/article/2d75ca2bfc4040fd898baa7771185ed1
Autor:
Mike Ludwig, Claire Newton, Ané Pieters, Natalie Z.M. Homer, Xiao Feng Li, Kevin T. O'Byrne, Robert P. Millar
Publikováno v:
General and Comparative Endocrinology. 329:114127
Understanding the hypothalamic factors regulating reproduction facilitates maximising the reproductive success of breeding programmes and in the management and conservation of threatened species, including African lions. To provide insight into the p
Autor:
Lorna Ginnell, Sinéad O’Carroll, Victoria Ledsham, Lorena Jiménez Sánchez, David Q. Stoye, Gemma Sullivan, Jill Hall, Natalie Z.M. Homer, James P. Boardman, Sue Fletcher-Watson, Rebecca M. Reynolds
Publikováno v:
Ginnell, L, O’Carroll, S, Ledsham, V, Jiménez Sánchez, L, Stoye, D Q, Sullivan, G, Hall, J, Homer, N Z M, Boardman, J P, Fletcher-Watson, S & Reynolds, R M 2022, ' Emotion regulation and cortisol response to the still-face procedure in preterm and full-term infants ', Psychoneuroendocrinology, vol. 141, pp. 105760 . https://doi.org/10.1016/j.psyneuen.2022.105760
In infancy, stress responses and emotion regulation are often coupled. Both are impacted by prematurity, thoughtheir relationship to one another in the case of infants born preterm is not fully understood. We investigatedemotion regulation behaviours
Autor:
Adam Gow, Susan Campbell, Richard J. Mellanby, Ian Handel, Dylan N. Clements, Donna Gaylor, Emma Hurst, Natalie Z.M. Homer, Helen Evans
Publikováno v:
Hurst, E, Homer, N, Gow, A, Clements, D, Evans, H, Gaylor, D, Campbell, S, Handel, I & Mellanby, R 2020, ' Vitamin D status is seasonally stable in northern European dogs ', Veterinary Clinical Pathology . https://doi.org/10.1111/vcp.12859
BackgroundNumerous studies in veterinary species have recently linked vitamin D status with non-skeletal health disorders. Previous studies have indicated that dogs cannot produce endogenous vitamin D via cutaneous production and rely solely on dieta
Autor:
Adrian Thompson, Vaughan S. Langford, Natalie Z.M. Homer, Michael Eddleston, Mark J Perkins, Colin Hastie
Publikováno v:
Hastie, C, Thompson, A, Perkins, M, Langford, V S, Eddleston, M & Homer, N Z M 2021, ' Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS) as an Alternative to Gas Chromatography/Mass Spectrometry (GC/MS) for the Analysis of Cyclohexanone and Cyclohexanol in Plasma ', ACS Omega . https://doi.org/10.1021/acsomega.1c03827
ACS Omega
ACS Omega, Vol 6, Iss 48, Pp 32818-32822 (2021)
ACS Omega
ACS Omega, Vol 6, Iss 48, Pp 32818-32822 (2021)
Self-poisoning with professional agricultural pesticide products is responsible for about 20% of global suicide, with most cases occurring in South Asia and China. Treatment of severe poisoning involves long-term intensive clinical care and is often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90396588c323a68426835d2962fc152a
https://www.pure.ed.ac.uk/ws/files/242328573/acsomega.1c03827.pdf
https://www.pure.ed.ac.uk/ws/files/242328573/acsomega.1c03827.pdf