Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Natalie Y. Chen"'
Autor:
Patrick J. Heizer, Ye Yang, Yiping Tu, Paul H. Kim, Natalie Y. Chen, Yan Hu, Yuko Yoshinaga, Pieter J. de Jong, Laurent Vergnes, Jazmin E. Morales, Robert L. Li, Nicholas Jackson, Karen Reue, Stephen G. Young, Loren G. Fong
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 3, Pp 413-421 (2020)
Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component of the nuclear lamina. In the absence of ZMPSTE24, farnesyl–prelamin A accumulates in the nucleus and exerts toxicity
Externí odkaz:
https://doaj.org/article/13a63de43af34811a3f699cc04d6c57d
Publikováno v:
Nucleus, Vol 11, Iss 1, Pp 237-249 (2020)
The nuclear membranes function as a barrier to separate the cell nucleus from the cytoplasm, but this barrier can be compromised by nuclear membrane ruptures, leading to intermixing of nuclear and cytoplasmic contents. Spontaneous nuclear membrane ru
Externí odkaz:
https://doaj.org/article/4cb55d56a0a941d7b14f8d53e39ae9db
Autor:
Paul H. Kim, Natalie Y. Chen, Patrick J. Heizer, Yiping Tu, Thomas A. Weston, Jared L.-C. Fong, Navjot Kaur Gill, Amy C. Rowat, Stephen G. Young, Loren G. Fong
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
The mutant nuclear lamin protein (progerin) produced in Hutchinson-Gilford progeria syndrome (HGPS) results in loss of arterial smooth muscle cells (SMCs), but the mechanism has been unclear. We found that progerin induces repetitive nuclear membrane
Externí odkaz:
https://doaj.org/article/782e92b7c80f4e82b3a9551cf8e5b14f
Autor:
Steven J. Jonas, Thomas D. Young, Natalie Y. Chen, Alexandra M. Mendoza, Naihao Chiang, Tony Jun Huang, Jason N. Belling, Yao Gong, Paul S. Weiss, Tzu-Ting Chiou, Leonardo Scarabelli, Satiro N. De Oliveira, Stephen G. Young, Liv K. Heidenreich, Adam Z. Stieg, Jae Hyeon Park, Natcha Wattanatorn, Zhenhua Tian, Jack Takahashi
Publikováno v:
Proc Natl Acad Sci U S A
Advances in gene editing are leading to new medical interventions where patients’ own cells are used for stem cell therapies and immunotherapies. One of the key limitations to translating these treatments to the clinic is the need for scalable tech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cffde92f6aba30e3929c7e6ce6fdbfa
https://doi.org/10.1073/pnas.1917125117
https://doi.org/10.1073/pnas.1917125117
Autor:
Loren G. Fong, Pieter J. de Jong, Paul Kim, Nicholas Jackson, Jazmin E. Morales, Yuko Yoshinaga, Patrick J. Heizer, Yan Hu, Ye Yang, Karen Reue, Stephen G. Young, Natalie Y. Chen, Yiping Tu, Robert L. Li, Laurent Vergnes
Publikováno v:
J Lipid Res
Journal of Lipid Research, Vol 61, Iss 3, Pp 413-421 (2020)
Journal of Lipid Research, Vol 61, Iss 3, Pp 413-421 (2020)
Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component of the nuclear lamina. In the absence of ZMPSTE24, farnesyl–prelamin A accumulates in the nucleus and exerts toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91fffcd94c9430392135240723c4f753
https://doi.org/10.1194/jlr.ra119000593
https://doi.org/10.1194/jlr.ra119000593
Autor:
Yiping Tu, Stephen G. Young, Paul Kim, Loren G. Fong, Natalie Y. Chen, Patrick J. Heizer, Ye Yang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 25
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Defects or deficiencies in nuclear lamins cause pathology in many cell types, and recent studies have implicated nuclear membrane (NM) ruptures as a cause of cell toxicity. We previously observed NM ruptures and progressive cell death in the developi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782f94abbd12d647c13c2ef14c32d829
https://escholarship.org/uc/item/2jx3j5f1
https://escholarship.org/uc/item/2jx3j5f1
Autor:
Juliana S. Powell, Yiping Tu, Stephen G. Young, Guillermo Rodríguez-Bey, Mara Sullivan, Kris Noel Dahl, Quasar S Padiath, Jianquan Xu, Natalie Y. Chen, Donna B. Stolz, Bruce Nmezi, Yang Liu, Rao Fu, Travis J. Armiger, Hongqiang Ma
Publikováno v:
Proceedings of the National Academy of Sciences. 116:4307-4315
The nuclear lamina is an intermediate filament meshwork adjacent to the inner nuclear membrane (INM) that plays a critical role in maintaining nuclear shape and regulating gene expression through chromatin interactions. Studies have demonstrated that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a1951de052f2f630e854d282cfc37d
https://doi.org/10.1073/pnas.1810070116
https://doi.org/10.1073/pnas.1810070116
Autor:
Stephen G. Young, Paul Kim, Amy C. Rowat, Patrick J. Heizer, Thomas A. Weston, Loren G. Fong, Navjot Kaur Gill, Natalie Y. Chen, Jared L.-C. Fong, Yiping Tu
Publikováno v:
JCI Insight
The mutant nuclear lamin protein (progerin) produced in Hutchinson-Gilford progeria syndrome (HGPS) results in loss of arterial smooth muscle cells (SMCs), but the mechanism has been unclear. We found that progerin induces repetitive nuclear membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca3024b2a09029014688642c5c36585
https://pubmed.ncbi.nlm.nih.gov/34423791
https://pubmed.ncbi.nlm.nih.gov/34423791
Autor:
Patrick J. Heizer, Lovelyn Edillo, Natalie Y. Chen, Thomas A. Weston, Loren G. Fong, Ye Yang, Yiping Tu, Paul Kim, Jason N. Belling, Stephen G. Young, Paul S. Weiss, Steven J. Jonas
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 51
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 51
Deficiencies in either lamin B1 or lamin B2 cause both defective migration of cortical neurons in the developing brain and reduced neuronal survival. The neuronal migration abnormality is explained by a weakened nuclear lamina that interferes with nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5a0a6f445398914f817c43536b3ce3
https://pubmed.ncbi.nlm.nih.gov/31796586
https://pubmed.ncbi.nlm.nih.gov/31796586
Autor:
Thomas A. Weston, Yiping Tu, Loren G. Fong, Lovelyn Edillo, Stephen G. Young, Natalie Y. Chen, Paul Kim
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 40
The nuclear lamina, an intermediate filament meshwork lining the inner nuclear membrane, is formed by the nuclear lamins (lamins A, C, B1, and B2). Defects or deficiencies in individual nuclear lamin proteins have been reported to elicit nuclear bleb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe9c2cc1f10cddcf01c6a0e4971a2f8
https://pubmed.ncbi.nlm.nih.gov/30224463
https://pubmed.ncbi.nlm.nih.gov/30224463