Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Natalie S. Scholes"'
Autor:
Chrysanthi Kagiou, Jose A. Cisneros, Jakob Farnung, Joanna Liwocha, Fabian Offensperger, Kevin Dong, Ka Yang, Gary Tin, Christina S. Horstmann, Matthias Hinterndorfer, Joao A. Paulo, Natalie S. Scholes, Juan Sanchez Avila, Michaela Fellner, Florian Andersch, J. Thomas Hannich, Johannes Zuber, Stefan Kubicek, Steven P. Gygi, Brenda A. Schulman, Georg E. Winter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Targeted protein degradation (TPD) relies on small molecules to recruit proteins to E3 ligases to induce their ubiquitylation and degradation by the proteasome. Only a few of the approximately 600 human E3 ligases are currently amenable to t
Externí odkaz:
https://doaj.org/article/122c230e01c4426bb2025a22bb1c70c0
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 5, p e1004935 (2016)
Transcriptional activation domains (ADs) are generally thought to be intrinsically unstructured, but capable of adopting limited secondary structure upon interaction with a coactivator surface. The indeterminate nature of this interface made it hithe
Externí odkaz:
https://doaj.org/article/8c416b49fbd64c4b83f874c19d3272a9
Publikováno v:
Cell Chemical Biology
The therapeutic modality of targeted protein degradation promises to overcome limitations of traditional pharmacology. Small-molecule degraders recruit disease-causing proteins to E3 ubiquitin ligases, prompting their ubiquitination and degradation b
Publikováno v:
257.e4
Summary Turing patterns (TPs) underlie many fundamental developmental processes, but they operate over narrow parameter ranges, raising the conundrum of how evolution can ever discover them. Here we explore TP design space to address this question an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45627a7504c07fa41eceb605291e4d1a
http://hdl.handle.net/10044/1/70533
http://hdl.handle.net/10044/1/70533
Turing patterns (TPs) underlie many fundamental developmental processes, but they operate over narrow parameter ranges, raising the conundrum of how evolution can ever discover them. Here we explore TP design space to address this question and to dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600335b858fbc499bb04050b532df18e
Autor:
Mark Isalan, Natalie S. Scholes
Publikováno v:
Current opinion in chemical biology. 40
The spatial organisation of gene expression is essential to create structure and function in multicellular organisms during developmental processes. Such organisation occurs by the execution of algorithmic functions, leading to patterns within a give