Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Natalie S Poulter"'
Autor:
Zahra Maqsood, Joanne C Clark, Eleyna M Martin, Yam Fung Hilaire Cheung, Luis A Morán, Sean E T Watson, Jeremy A Pike, Ying Di, Natalie S Poulter, Alexandre Slater, Bodo M H Lange, Bernhard Nieswandt, Johannes A Eble, Mike G Tomlinson, Dylan M Owen, David Stegner, Lloyd J Bridge, Christoph Wierling, Steve P Watson
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 11, p e1010708 (2022)
The clustering of platelet glycoprotein receptors with cytosolic YxxL and YxxM motifs, including GPVI, CLEC-2 and PEAR1, triggers activation via phosphorylation of the conserved tyrosine residues and recruitment of the tandem SH2 (Src homology 2) dom
Externí odkaz:
https://doaj.org/article/4aa0aa11395e4e1d8253e586a4861727
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31423 (2012)
ROCK1 and ROCK2 are serine/threonine kinases that function downstream of the small GTP-binding protein RhoA. Rho signalling via ROCK regulates a number of cellular functions including organisation of the actin cytoskeleton, cell adhesion and cell mig
Externí odkaz:
https://doaj.org/article/d5b58237182447a5b69e5d35f5d359f8
Autor:
Natalie J. Jooss, Yvonne M.C. Henskens, Steve P. Watson, Richard W. Farndale, Meinrad P. Gawaz, Martine Jandrot-Perrus, Natalie S. Poulter, Johan W. M. Heemskerk
Publikováno v:
Thrombosis and Haemostasis, 123(06), 597-612. Georg Thieme Verlag
Background In secondary cardiovascular disease prevention, treatments blocking platelet-derived secondary mediators pose a risk of bleeding. Pharmacological interference of the interaction of platelets with exposed vascular collagens is an attractive
Autor:
Foteini-Nafsika Damaskinaki, Natalie J. Jooss, Eleyna M. Martin, Joanne C. Clark, Mark R. Thomas, Natalie S. Poulter, Jonas Emsley, Barrie Kellam, Steve P. Watson, Alexandre Slater
Publikováno v:
Journal of Thrombosis and Haemostasis. Wiley
BACKGROUND: The platelet-signaling receptor glycoprotein VI (GPVI) is a promising antithrombotic target. We have previously raised a series of high-affinity nanobodies (Nbs) against GPVI and identified Nb2, Nb21, and Nb35 as potent GPVI inhibitors. T
Autor:
Chek Ziu Koo, Alexandra L. Matthews, Neale Harrison, Justyna Szyroka, Bernhard Nieswandt, Elizabeth E. Gardiner, Natalie S. Poulter, Michael G. Tomlinson
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2440 (2022)
The platelet-activating collagen receptor GPVI represents the focus of clinical trials as an antiplatelet target for arterial thrombosis, and soluble GPVI is a plasma biomarker for several human diseases. A disintegrin and metalloproteinase 10 (ADAM1
Externí odkaz:
https://doaj.org/article/87659b7c4198463b847b3ff79a0e3b38
Autor:
Martina Colicchia, Waltraud C. Schrottmaier, Gina Perrella, Jasmeet S. Reyat, Jenefa Begum, Alexandre Slater, Joshua Price, Joanne C. Clark, Zhaogong Zhi, Megan J. Simpson, Joshua H. Bourne, Natalie S. Poulter, Abdullah O. Khan, Phillip L. R. Nicolson, Matthew Pugh, Paul Harrison, Asif J. Iqbal, George E. Rainger, Steve P. Watson, Mark R. Thomas, Nicola J. Mutch, Alice Assinger, Julie Rayes
Publikováno v:
Blood, 140(24), 2626-2643. The American Society of Hematology
S100A8/A9, also known as “calprotectin” or “MRP8/14,” is an alarmin primarily secreted by activated myeloid cells with antimicrobial, proinflammatory, and prothrombotic properties. Increased plasma levels of S100A8/A9 in thrombo-inflammatory
Autor:
Christopher W. Smith, Maan H. Harbi, Lourdes Garcia‐Quintanilla, Kieran Rookes, Helena Brown, Natalie S. Poulter, Steve P. Watson, Phillip L.R. Nicolson, Mark R. Thomas
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2939-2952
New antithrombotic therapies with less effect on bleeding are needed for coronary artery disease. The Btk inhibitor ibrutinib blocks atherosclerotic plaque-mediated thrombus formation. However, it is associated with increased bleeding, possibly due t
Autor:
Samantha J. Montague, Céline Delierneux, Christelle Lecut, Nathalie Layios, Robert J. Dinsdale, Christine S.-M. Lee, Natalie S. Poulter, Robert K. Andrews, Peter Hampson, Christopher M. Wearn, Nathalie Maes, Jonathan Bishop, Amy Bamford, Chris Gardiner, Woei Ming Lee, Tariq Iqbal, Naiem Moiemen, Steve P. Watson, Cécile Oury, Paul Harrison, Elizabeth E. Gardiner
Publikováno v:
Blood Advances, Vol 2, Iss 3, Pp 240-251 (2018)
Abstract: Soluble glycoprotein VI (sGPVI) is shed from the platelet surface and is a marker of platelet activation in thrombotic conditions. We assessed sGPVI levels together with patient and clinical parameters in acute and chronic inflammatory cond
Externí odkaz:
https://doaj.org/article/2548f9d08ed64c8daa500e2cf9e58b32
Autor:
Mark R Thomas, Andrew B. Herr, Natalie J Jooss, Joanne C. Clark, Natalie S. Poulter, Robert A. S. Ariëns, Jonas Emsley, Eleyna M. Martin, Stephen P. Watson, Fawaz Obaidullah Alenazy, Ying Di, Alexandre Slater
Publikováno v:
Blood
Blood, 137(24), 3443-3453. The American Society of Hematology
Blood, 137(24), 3443-3453. The American Society of Hematology
Glycoprotein VI (GPVI) is the major signaling receptor for collagen on platelets. We have raised 54 nanobodies (Nb), grouped into 33 structural classes based on their complementary determining region 3 loops, against recombinant GPVI-Fc (dimeric GPVI
Autor:
Joshua H. Bourne, Christopher W. Smith, Natalie J. Jooss, Ying Di, Helena C. Brown, Samantha J. Montague, Mark R. Thomas, Natalie S. Poulter, Julie Rayes, Steve P. Watson
Publikováno v:
Thrombosis and Haemostasis, 122(12), 1988-2000. Georg Thieme Verlag
C-type lectin-like receptor 2 (CLEC-2) is highly expressed on platelets and a subpopulation of myeloid cells, and is critical in lymphatic development. CLEC-2 has been shown to support thrombus formation at sites of inflammation, but to have a minor/