Výsledky vyhledávání - "Natalie Ronaghan"

The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction

Autor: Raza S. Zaheer, Jerrold R. Turner, Natalie Ronaghan, Pina Colarusso, Richard Leduc, Wallace K. MacNaughton, Judie Shang, Antoine Désilets, Vadim Iablokov, Sébastien P. Dion

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 311:G466-G479

Barrier dysfunction is a characteristic of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Understanding how the tight junction is modified to maintain barrier function may provide avenues for treatment of IBD. We have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63efc14b2540b2a5dd50998e3379bf3f
https://doi.org/10.1152/ajpgi.00441.2015

Zobrazit plný text záznamu

Probiotics Improve Inflammation-Associated Sickness Behavior by Altering Communication between the Peripheral Immune System and the Brain

Autor: Natalie Ronaghan, Michael G. Surrette, Mark G. Swain, Raza S. Zaheer, Michael Dicay, Charlotte D'Mello, Tai Le, Wallace K. MacNaughton

Publikováno v: Journal of Neuroscience. 35:10821-10830

Patients with systemic inflammatory diseases (e.g., rheumatoid arthritis, inflammatory bowel disease, chronic liver disease) commonly develop debilitating symptoms (i.e., sickness behaviors) that arise from changes in brain function. The microbiota-g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94daf51f5a1163843bb2f62c74f409b0
https://doi.org/10.1523/jneurosci.0575-15.2015

Zobrazit plný text záznamu

Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function

Autor: Antoine Désilets, Richard Leduc, Wallace K. MacNaughton, Sébastien P. Dion, Judie Shang, Natalie Ronaghan, Kelcie Lahey

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0180259 (2017)

Changes in barrier function of the gastrointestinal tract are thought to contribute to the inflammatory bowel diseases Crohn's disease and ulcerative colitis. Previous work in our lab demonstrated that apical exposure of intestinal epithelial cell li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b61154fdec0d55b2de6018f271bbd26
http://europepmc.org/articles/PMC5495298

Zobrazit plný text záznamu

Interferon-γ suppresses intestinal epithelial aquaporin-1 expression via Janus kinase and STAT3 activation

Autor: Raza S. Zaheer, Christina L. Hirota, Natalie Ronaghan, Michael Dicay, Michael A. Peplowski, Colin A. Carati, Wallace K. MacNaughton

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0118713 (2015)
PLoS ONE

Inflammatory bowel diseases are associated with dysregulated electrolyte and water transport and resultant diarrhea. Aquaporins are transmembrane proteins that function as water channels in intestinal epithelial cells. We investigated the effect of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095a5ed1f54cc1e4980dfc2cce0f3611
http://europepmc.org/articles/PMC4405000?pdf=render

Zobrazit plný text záznamu

Serine protease modulation of epithelial barrier function through the tight junction (650.8)

Autor: Natalie Ronaghan, Wallace K. MacNaughton

Publikováno v: The FASEB Journal. 28

Inflammatory mediator-induced disruption of the tight junction may contribute to pathogenesis of IBD through increased intestinal permeability. We have previously found apical addition of the serin...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6bb98e7f8a85f5f25bc3fadd214dd73
https://doi.org/10.1096/fasebj.28.1_supplement.650.8

Zobrazit plný text záznamu

Targeting Mitochondria-Derived Reactive Oxygen Species to Reduce Epithelial Barrier Dysfunction and Colitis

Autor: Åsa V. Keita, Michael P. Murphy, Wallace K. MacNaughton, Joshua Lee, Natalie Ronaghan, Robin M. Yates, Ida Schoultz, Catherine M. McKay, Derek M. McKay, Van Phan, Maria Fernando, Michael Dicay, Arthur Wang, Paul L. Beck, Dale R. Balce, Johan D. Söderholm

Publikováno v: The American Journal of Pathology. (9):2516-2527

Epithelial permeability is often increased in inflammatory bowel diseases. We hypothesized that perturbed mitochondrial function would cause barrier dysfunction and hence epithelial mitochondria could be targeted to treat intestinal inflammation. Mit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aef07dc13df9f512713ca14438c8fa7

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání