A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.

Autor: Makiko Taira, Minako Imamura, Atsushi Takahashi, Yoichiro Kamatani, Toshimasa Yamauchi, Shin-Ichi Araki, Nobue Tanaka, Natalie R van Zuydam, Emma Ahlqvist, Masao Toyoda, Tomoya Umezono, Koichi Kawai, Masahito Imanishi, Hirotaka Watada, Daisuke Suzuki, Hiroshi Maegawa, Tetsuya Babazono, Kohei Kaku, Ryuzo Kawamori, SUMMIT Consortium, Leif C Groop, Mark I McCarthy, Takashi Kadowaki, Shiro Maeda

Publikováno v: PLoS ONE, Vol 13, Iss 12, p e0208654 (2018)

To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (

Externí odkaz: https://doaj.org/article/b7d9dc02c33e497781b39a7048146b3e

Genetic loci for retinal arteriolar microcirculation.

Autor: Xueling Sim, Richard A Jensen, M Kamran Ikram, Mary Frances Cotch, Xiaohui Li, Stuart MacGregor, Jing Xie, Albert Vernon Smith, Eric Boerwinkle, Paul Mitchell, Ronald Klein, Barbara E K Klein, Nicole L Glazer, Thomas Lumley, Barbara McKnight, Bruce M Psaty, Paulus T V M de Jong, Albert Hofman, Fernando Rivadeneira, Andre G Uitterlinden, Cornelia M van Duijn, Thor Aspelund, Gudny Eiriksdottir, Tamara B Harris, Fridbert Jonasson, Lenore J Launer, Wellcome Trust Case Control Consortium, John Attia, Paul N Baird, Stephen Harrap, Elizabeth G Holliday, Michael Inouye, Elena Rochtchina, Rodney J Scott, Ananth Viswanathan, Global BPGen Consortium, Guo Li, Nicholas L Smith, Kerri L Wiggins, Jane Z Kuo, Kent D Taylor, Alex W Hewitt, Nicholas G Martin, Grant W Montgomery, Cong Sun, Terri L Young, David A Mackey, Natalie R van Zuydam, Alex S F Doney, Colin N A Palmer, Andrew D Morris, Jerome I Rotter, E Shyong Tai, Vilmundur Gudnason, Johannes R Vingerling, David S Siscovick, Jie Jin Wang, Tien Y Wong

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e65804 (2013)

Narrow arterioles in the retina have been shown to predict hypertension as well as other vascular diseases, likely through an increase in the peripheral resistance of the microcirculatory flow. In this study, we performed a genome-wide association st

Externí odkaz: https://doaj.org/article/6ccad1da877741939787723ca8571867

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

Autor: Urmo Võsa, Alexander Kurilshikov, Marije Oosting, Leo A. B. Joosten, Natalie R. van Zuydam, Daisy Jonkers, Jingyuan Fu, Serena Sanna, Zlatan Mujagic, Mark I. McCarthy, Ad A.M. Masclee, Lude Franke, Alexandra Zhernakova, Mihai G. Netea, Cisca Wijmenga, Anubha Mahajan, Arnau Vich Vila

Publikováno v: Nature Genetics, 51(4), 600-605. Nature Publishing Group
Nature Genetics, 51, 600-605
Nature Genetics, 51, 4, pp. 600-605
Nature Genetics

Contains fulltext : 202884.pdf (Publisher’s version ) (Closed access) Microbiome-wide association studies on large population cohorts have highlighted associations between the gut microbiome and complex traits, including type 2 diabetes (T2D) and o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4e37c351eec51a83ae0026666e1fea
https://hdl.handle.net/11370/aacefc2e-1376-4ba0-b904-adbd28797acf

Genome-Wide Association Study of Peripheral Artery Disease

Autor: Natalie R. van Zuydam, Alexander Stiby, Moustafa Abdalla, Erin Austin, Emma H. Dahlström, Stela McLachlan, Efthymia Vlachopoulou, Emma Ahlqvist, Chen Di Liao, Niina Sandholm, Carol Forsblom, Anubha Mahajan, Neil R. Robertson, N. William Rayner, Eero Lindholm, Juha Sinisalo, Markus Perola, Milla Kallio, Emily Weiss, Jackie Price, Andrew Paterson, Barbara Klein, Veikko Salomaa, Colin N.A. Palmer, Per-Henrik Groop, Leif Groop, Mark I. McCarthy, Mariza de Andrade, Andrew P. Morris, Jemma C. Hopewell, Helen M. Colhoun, Iftikhar J. Kullo, Sólveig Grétarsdóttir, Guðmar Þorleifsson, Unnur þorsteinsdóttir, Kari Stefansson, Michael Mark, Timo Kanninen, Barbara Thorand, Giuseppe Remuzzi, David Dunger, Angela Shore, Ulf Smith, Seppo Ylä-Herttuala, Claudio Cobelli, Riccardo Bellazzi, Ele Ferrannini, Carlo Patrono, Pirjo Nuutila, Paul McKeague, Birgit Steckel-Hamann, Li-ming Gan, Everson Nogoceke, Piero Tortoli, Bernd Jablonka, Mary-Julia Brosnan

Publikováno v: Circulation. Genomic and Precision Medicine
Van Zuydam, N R, Stiby, A, Abdalla, M, Dahlstrom, EH, McLachlan, S, Vlachopoulou, E, Price, J F, Ahlqvist, E, Di Liao, C, Sandholm, N, Forsblom, C, Mahajan, A, Robertson, N R, Rayner, N W, Lindholm, E, Sinisalo, J, Perola, M, Kallio, M, Weiss, E, Paterson, A, Klein, B, Salomaa, V, McCarthy, M, de Andrade, M, Morris, AP, Hopewell, JC, Colhoun, H M & Kullo, IJ 2021, ' A genome-wide association study of peripheral artery disease ', Circulation: Genomic and Precision Medicine . https://doi.org/10.1161/CIRCGEN.119.002862
Circ. Genom. Precis. Med. 14:e002862 (2021)
Circulation: Genomic and Precision Medicine

Supplemental Digital Content is available in the text.
Background: Peripheral artery disease (PAD) affects >200 million people worldwide and is associated with high mortality and morbidity. We sought to identify genomic variants associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1331a7c40e7d9286577d43c5d5fbb16a
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-458405

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Autor: David Torrents, Thorkild I. A. Sørensen, André G. Uitterlinden, Dorret I. Boomsma, Harry Campbell, Vasiliki Lagou, Joachim Heinrich, Anna Murray, Nicholas J. Timpson, George Dedoussis, Beverley M. Shields, Timo A. Lakka, Lawrence J. Beilin, Carmen J. Marsit, Katharina E. Schraut, Marie Standl, Torben Hansen, James F. Wilson, Jonas Bacelis, Allan Vaag, Louis J. Muglia, Wei Ang, Josep M. Mercader, Ruifang Li-Gao, Ying Wu, Jessica Tyrrell, Pål R. Njølstad, Mohammad Hadi Zafarmand, Marie-France Hivert, Ioanna Ntalla, Debbie A Lawlor, Martina Müller-Nurasyid, Alana Cavadino, Natalia Vilor-Tejedor, Andrew R. Wood, Zoltán Kutalik, Jodie N. Painter, Tanja G. M. Vrijkotte, Kyle J. Gaulton, Xavier Estivill, George Davey Smith, Christine Power, Andrew T. Hattersley, Berthold Hocher, Gibran Hemani, Sheila J. Barton, Aino-Maija Eloranta, Kathryn L. Lunetta, Kim F. Michaelsen, Frank Geller, Bjarke Feenstra, Carol A. Wang, Peter Vollenweider, Wieland Kiess, Anubha Mahajan, Elina Hyppönen, Elisabeth M. van Leeuwen, Felix R. Day, Natalie R. van Zuydam, Leda Chatzi, Bo L. Chawes, Antje Körner, Dennis O. Mook-Kanamori, Ken K. Ong, Joanne M. Murabito, David M. Hougaard, Jian'an Luan, Letizia Marullo, Catharina E. M. van Beijsterveldt, Yik Ying Teo, Andrew P. Morris, Sarah E. Medland, Juan Fernández-Tajes, Jouke-Jan Hottenga, Frits R. Rosendaal, Inga Prokopenko, Katja Pahkala, Struan F.A. Grant, Sylvain Sebert, Judith B. Borja, Camilla Schmidt Morgen, Charlotta Pisinger, Jia Chen, Øyvind Helgeland, Christian Theil Have, Vincent W. V. Jaddoe, Marjolein N. Kooijman, Mika Kähönen, Timothy M. Frayling, Diana L. Cousminer, Bo Jacobsson, Antoine H. C. van Kampen, Eco J. C. de Geus, Manolis Kogevinas, Rico Rueedi, Grant W. Montgomery, Raimo Joro, Craig E. Pennell, Jonathan P. Bradfield, Janine F. Felix, Ge Zhang, Loreto Santa-Marina, Kalliope Panoutsopoulou, John R. B. Perry, Jeff Murray, Albert Hofman, Terho Lehtimäki, John W. Holloway, Barbera D. C. van Schaik, Pedro Marques-Vidal, Ronny Myhre, Haja N. Kadarmideen, Robert A. Scott, Frank D. Mentch, Katherine S. Ruth, Hans Bisgaard, Marjo-Riitta Järvelin, Catherine Allard, Rachel M. Freathy, Julie A. Marsh, Mariona Bustamante, Elisabeth Thiering, Cæcilie Trier, Marcus A. Tuke, William L. Lowe, Elisabeth Widen, Caroline L Relton, Christoph Reichetzeder, Penelope A. Lind, M. Geoffrey Hayes, Charles Laurin, Tarunveer S. Ahluwalia, Meike Bartels, Mads Melbye, Claudia Langenberg, Ke Hao, Shouneng Peng, Nicholas J. Wareham, Susan M. Ring, Hamdi Mbarek, Mario Murcia, Jing Hua Zhao, Michael Nodzenski, Cornelia M. van Duijn, Hakon Hakonarson, Hanieh Yaghootkar, Po-Ru Loh, Linda S. Adair, Sílvia Bonàs-Guarch, Eleftheria Zeggini, Sarah Metrustry, Shikta Das, Gonneke Willemsen, Ana Espinosa, Lavinia Paternoster, Marc Vaudel, Theresia M. Schnurr, Michael Stumvoll, David M. Evans, Bridget A. Knight, Luigi Bouchard, Robin N Beaumont, Mustafa Atalay, Zhen Qiao, Denise M. Scholtens, Klaus Bønnelykke, Samuel E. Jones, Peter K. Joshi, Oluf Pedersen, Jin-Fang Chai, Fernando Rivadeneira, Leo-Pekka Lyytikäinen, Rebecca K. Vinding, Hazel Inskip, Sara M. Willems, Cilius Esmann Fonvig, Momoko Horikoshi, Ellen A. Nohr, Jani Heikkinen, Emil V. R. Appel, Niels Grarup, Michael N. Weedon, Rebecca C Richmond, Peter Kovacs, Jorma Viikari, Amanda J. Bennett, Jens-Christian Holm, Carolina Medina-Gomez, Nicole M. Warrington, Anke Tönjes, Jakob Stokholm, Hugoline G. de Haan, Seang-Mei Saw, Ville Huikari, N. William Rayner, Johan G. Eriksson, Niina Pitkänen, Allan Linneberg, Gunn-Helen Moen, Olli T. Raitakari, Martine Vrijheid, Neil Robertson, Stefan Johansson, Tim D. Spector, Friman Sánchez, Mark I. McCarthy, Harri Niinikoski, Karen L. Mohlke

Publikováno v: Warrington, N M, Beaumont, R N, Horikoshi, M, Day, F R, Helgeland, Ø, Laurin, C, Bacelis, J, Peng, S, Hao, K, Feenstra, B, Wood, A R, Mahajan, A, Tyrrell, J, Robertson, N R, Rayner, N W, Qiao, Z, Moen, G-H, Vaudel, M, Marsit, C J, Chen, J, Nodzenski, M, Schnurr, T M, Zafarmand, M H, Bradfield, J P, Grarup, N, Kooijman, M N, Li-Gao, R, Geller, F, Ahluwalia, T S, Paternoster, L, Rueedi, R, Huikari, V, Hottenga, J-J, Lyytikäinen, L-P, Cavadino, A, Metrustry, S, Cousminer, D L, Wu, Y, Thiering, E, Wang, C A, Have, C T, Vilor-Tejedor, N, Joshi, P K, Painter, J N, Ntalla, I, Myhre, R, Pitkänen, N, van Leeuwen, E M, Joro, R, Lagou, V, Richmond, R C, Espinosa, A, Barton, S J, Inskip, H M, Holloway, J W, Marina, L S, Estivill, X, Ang, W, Marsh, J A, Reichetzeder, C, Marullo, L, Hocher, B, Lunetta, K L, Murabito, J M, Relton, C L, Kogevinas, M, Chatzi, L, Allard, C, Bouchard, L, Hivert, M-F, Zhang, G, Muglia, L J, Heikkinen, J, Morgen, C S, van Kampen, A H C, van Schaik, B D C, Mentch, F D, Langenberg, C, Luan, J, Scott, R A, Zhao, J H, Hemani, G, Ring, S M, Bennett, A J, Gaulton, K J, Fernandez-Tajes, J, van Zuydam, N R, Medina-Gomez, C, de Haan, H G, Rosendaal, F R, Kutalik, Z, Marques-Vidal, P, Das, S, Willemsen, G, Mbarek, H, Müller-Nurasyid, M, Standl, M, Appel, E V R, Fonvig, C E, Trier, C, van Beijsterveldt, C E M, Murcia, M, Bustamante, M, Bonas-Guarch, S, Hougaard, D M, Mercader, J M, Linneberg, A, Schraut, K, Lind, P A, Medland, S E, Shields, B M, Knight, B A, Chai, J-F, Panoutsopoulou, K, Bartels, M, Sánchez, F, Stokholm, J, Torrents, D, Vinding, R K, Willems, S M, Atalay, M, Chawes, B L, Kovacs, P, Prokopenko, I, Tuke, M A, Yaghootkar, H, Ruth, K S, Jones, S E, Loh, P-R, Murray, A, Weedon, M N, Tönjes, A, Stumvoll, M, Michaelsen, K F, Eloranta, A-M, Lakka, T A, van Duijn, C M, Kiess, W, Körner, A, Niinikoski, H, Pahkala, K, Raitakari, O T, Jacobsson, B, Zeggini, E, Dedoussis, G V, Teo, Y Y, Saw, S M, Montgomery, G W, Campbell, H, Wilson, J F, Vrijkotte, T G M, Vrijheid, M, de Geus, E J C N, Hayes, M G, Kadarmideen, H N, Holm, J-C, Beilin, L J, Pennell, C E, Heinrich, J, Adair, L S, Borja, J B, Mohlke, K L, Eriksson, J G, Widén, E, Hattersley, A T, Spector, T D, Kähönen, M, Viikari, J S, Lehtimäki, T, Boomsma, D I, Sebert, S, Vollenweider, P, Sørensen, T I A, Bisgaard, H, Bønnelykke, K, Murray, J C, Melbye, M, Nohr, E A, Mook-Kanamori, D O, Rivadeneira, F, Hofman, A, Felix, J F, Jaddoe, V W V, Hansen, T, Pisinger, C, Vaag, A A, Pedersen, O, Uitterlinden, A G, Järvelin, M-R, Power, C, Hyppönen, E, Scholtens, D M, Lowe Jr, W L, Smith, G D, Timpson, N J, Morris, A P, Wareham, N J, Hakonarson, H, Grant, S F A, Frayling, T M, Lawlor, D A, Njølstad, P R, Johansson, S, Ong, K K, McCarthy, M I, Perry, J R B & Evans, D M & Freathy, R M 2019, ' Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors ', Nature Genetics, vol. 51, no. 5, pp. 804–814 . https://doi.org/10.1038/s41588-019-0403-1
Warrington, N M, Li-Gao, R, Hottenga, J J, Willemsen, G, Mbarek, H, van Beijsterveldt, C E M, Bartels, M, de Geus, E J C N, Boomsma, D I, Freathy, R M & EGG Consortium 2019, ' Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors ', Nature Genetics, vol. 51, no. MAY, pp. 804-814 . https://doi.org/10.1038/s41588-019-0403-1
Nature Genetics, 51(MAY), 804-814. Nature Publishing Group
Warrington, N M, Beaumont, R N, Horikoshi, M, Day, F R, Helgeland, Ø, Laurin, C, Bacelis, J, Peng, S, Hao, K, Feenstra, B, Wood, A R, Mahajan, A, Tyrrell, J, Robertson, N R, Rayner, N W, Qiao, Z, Moen, G H, Vaudel, M, Marsit, C J, Chen, J, Nodzenski, M, Schnurr, T M, Zafarmand, M H, Bradfield, J P, Grarup, N, Kooijman, M N, Li-Gao, R, Geller, F, Ahluwalia, T S, Paternoster, L, Rueedi, R, Huikari, V, Hottenga, J J, Lyytikäinen, L P, Cavadino, A, Metrustry, S, Cousminer, D L, Wu, Y, Thiering, E, Wang, C A, Have, C T, Vilor-Tejedor, N, Joshi, P K, Painter, J N, Ntalla, I, Myhre, R, Morgen, C S, Fonvig, C E, Nohr, E A, Hansen, T & EGG Consortium 2019, ' Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors ', Nature Genetics, vol. 51, no. 5, pp. 804-814 . https://doi.org/10.1038/s41588-019-0403-1
Nature Genetics, 51(5), 804
Warrington, N M, Beaumont, R N, Horikoshi, M, Day, F R, Helgeland, Ø, Laurin, C, Bacelis, J, Peng, S, Hao, K, Feenstra, B, Wood, A R, Mahajan, A, Tyrrell, J, Robertson, N R, Rayner, N W, Qiao, Z, Moen, G-H, Vaudel, M, Marsit, C J, Chen, J J J, Nodzenski, M, Schnurr, T M, Zafarmand, M H, Bradfield, J P, Grarup, N, Kooijman, M N, Li-Gao, R, Geller, F, Ahluwalia, T S, Paternoster, L, Rueedi, R, Huikari, V, Hottenga, J-J, Lyytikäinen, L-P, Cavadino, A, Metrustry, S, Cousminer, D L, Wu, Y, Thiering, E, Wang, C A, Have, C T, Vilor-Tejedor, N, Joshi, P K, Painter, J N, Ntalla, I, Myhre, R, Pitkänen, N, van Leeuwen, E M, Joro, R, Lagou, V, Richmond, R C, Espinosa, A, Barton, S J, Inskip, H M, Holloway, J W, Santa-Marina, L, Estivill, X, Ang, W, Marsh, J A, Reichetzeder, C, Marullo, L, Hocher, B, Lunetta, K L, Murabito, J M, Relton, C L, Kogevinas, M, Chatzi, L, Allard, C, Bouchard, L, Hivert, M-F, Zhang, G, Muglia, L J, Heikkinen, J, Consortium, EGG, Morgen, C S, van Kampen, A H C, van Schaik, B D C, Mentch, F D, Langenberg, C, Luan, J, Scott, R A, Zhao, J H, Hemani, G, Ring, S M, Bennett, A J, Gaulton, K J, Fernandez-Tajes, J, van Zuydam, N R, Medina-Gomez, C, de Haan, H G, Rosendaal, F R, Kutalik, Z, Marques-Vidal, P, Das, S, Willemsen, G, Mbarek, H, Müller-Nurasyid, M, Standl, M, Appel, E V R, Fonvig, C E, Trier, C, van Beijsterveldt, C E M, Murcia, M, Bustamante, M, Bonas-Guarch, S, Hougaard, D M, Mercader, J M, Linneberg, A, Schraut, K E, Lind, P A, Medland, S E, Shields, B M, Knight, B A, Chai, J-F, Panoutsopoulou, K, Bartels, M, Sánchez, F, Stokholm, J, Torrents, D, Vinding, R K, Willems, S M, Atalay, M, Chawes, B L, Kovacs, P, Prokopenko, I, Tuke, M A, Yaghootkar, H, Ruth, K S, Jones, S E, Loh, P-R, Murray, A, Weedon, M N, Tönjes, A, Stumvoll, M, Michaelsen, K F, Eloranta, A-M, Lakka, T A, van Duijn, C M, Kiess, W, Körner, A, Niinikoski, H, Pahkala, K, Raitakari, O T, Jacobsson, B, Zeggini, E, Dedoussis, G V, Teo, Y-Y, Saw, S-M, Montgomery, G W, Campbell, H, Wilson, J F, Vrijkotte, T G M, Vrijheid, M, de Geus, E J C N, Hayes, M G, Kadarmideen, H N, Holm, J-C, Beilin, L J, Pennell, C E, Heinrich, J, Adair, L S, Borja, J B, Mohlke, K L, Eriksson, J G, Widén, E E, Hattersley, A T, Spector, T D, Kähönen, M, Viikari, J S, Lehtimäki, T, Boomsma, D I, Sebert, S, Vollenweider, P, Sørensen, T I A, Bisgaard, H F, Bønnelykke, K, Murray, J C, Melbye, M, Nohr, E A, Mook-Kanamori, D O, Rivadeneira, F, Hofman, A, Felix, J F, Jaddoe, V W V, Hansen, T, Pisinger, C, Vaag, A A, Pedersen, O, Uitterlinden, A G, Järvelin, M-R, Power, C, Hyppönen, E, Scholtens, D M, Lowe, W L, Davey Smith, G, Timpson, N J, Morris, A P, Wareham, N J, Hakonarson, H, Grant, S F A, Frayling, T M, Lawlor, D A, Njølstad, P R, Johansson, S, Ong, K K, McCarthy, M I, Perry, J R B, Evans, D M & Freathy, R M 2019, ' Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors ', Nature Genetics, vol. 51, no. 5, pp. 804-814 . https://doi.org/10.1038/s41588-019-0403-1
Nature Genetics, 51(5), 804-814. Nature Publishing Group
Nature Genetics
EGG Consortium & Morris, A P 2019, ' Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors ', Nature Genetics, vol. 51, no. 5, pp. 804-814 . https://doi.org/10.1038/s41588-019-0403-1
NATURE GENETICS
r-FISABIO. Repositorio Institucional de Producción Científica
instname
Nat. Genet. 51, 804-814 (2019)
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Nature Genetics, 51(5), 804-+. Nature Publishing Group
Nature genetics, 51(5), 804-814. Nature Publishing Group
2019, ' Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors ', Nature Genetics, vol. 51, no. 5, pp. 804-814 . https://doi.org/10.1038/s41588-019-0403-1

Birth weight (BW) variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. These associations have been proposed to reflect the lifelong conseque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d827b8c5a784827a5a5b94b330c98d
https://eprints.soton.ac.uk/430656/