PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis

Autor: Alessandro Cascioferro, Michael B. Zimmermann, Uwe Sauer, Wafa Frigui, Giulia Degiacomi, Francesca Boldrin, Marco Bellinzoni, Riccardo Manganelli, Natalie R. Lazar-Adler, Helen M. O'Hare, Andrew R. Bottrill, María-Natalia Lisa, Barbara Rieck, Pedro M. Alzari, Fabien Le Chevalier, Liem Nguyen, Roland Brosch

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2017, 13 (5), pp.e1006399. ⟨10.1371/journal.ppat.1006399⟩
PLoS Pathogens, 13 (5)
PLoS Pathogens, 2017, 13 (5), pp.e1006399. ⟨10.1371/journal.ppat.1006399⟩
PLoS Pathogens, Vol 13, Iss 5, p e1006399 (2017)

Sensing and response to changes in nutrient availability are essential for the lifestyle of environmental and pathogenic bacteria. Serine/threonine protein kinase G (PknG) is required for virulence of the human pathogen Mycobacterium tuberculosis, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f943836b17f793918750c2a931dd0fe6
https://hal-pasteur.archives-ouvertes.fr/pasteur-01570229

Correction: Identification of a Predicted Trimeric Autotransporter Adhesin Required for Biofilm Formation of Burkholderia pseudomallei

Autor: Rachel E. Dean, Mark P. Stevens, Edouard E. Galyov, Richard J. Saint, Joann L. Prior, Timothy P. Atkins, Natalie R. Lazar Adler

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 1 (2014)
PLoS ONE, Vol 8, Iss 11, p e79461 (2013)
Lazar-Adler, NR, Dean, RE, Saint, RJ, Stevens, M, Prior, JL, Atkins, TP & Galyov, EE 2013, ' Identification of a predicted trimeric autotransporter adhesin required for biofilm formation of Burkholderia pseudomallei. ', PLoS ONE, vol. 8, no. 11, e79461 . https://doi.org/10.1371/journal.pone.0079461

The autotransporters are a large and diverse family of bacterial secreted and outer membrane proteins, which are present in many Gram-negative bacterial pathogens and play a role in numerous environmental and virulence-associated interactions. As par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b3fca83d10604fb7b1cb2de6165f8a
http://europepmc.org/articles/PMC5861741

Autotransporters and their role in the virulence of Burkholderia pseudomallei and Burkholderia mallei

Autor: Edouard E. Galyov, Mark P. Stevens, Natalie R. Lazar Adler, Joanne M. Stevens

Publikováno v: Lazar Adler, N, Stevens, J, Stevens, M & Galyov, E 2011, ' Autotransporters and their role in the virulence of Burkholderia pseudomallei and Burkholderia mallei ', Frontiers in Microbiology, vol. 2, 151 . https://doi.org/10.3389/fmicb.2011.00151
Frontiers in Cellular and Infection Microbiology, Vol 2 (2011)
Frontiers in Microbiology

Burkholderia pseudomallei and Burkholderia mallei are closely related Gram-negative bacteria responsible for the infectious diseases melioidosis and glanders, respectively. Autotransporters (ATs) comprise a large and diverse family of secreted and ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b148db00ae2929ba8658f4ef67ac0aa6
https://www.pure.ed.ac.uk/ws/files/10560061/Autotransporters_and_their_role_in_the_virulence_of_Burkholderia_pseudomallei_and_Burkholderia_mallei.pdf

Perturbation of the two-component signal transduction system, BprRS, results in attenuated virulence and motility defects in Burkholderia pseudomallei

Autor: John D. Boyce, Natalie R. Lazar Adler, Brenda Govan, Elizabeth M. Allwood, Puthayalai Treerat, Rodney J. Devenish, Marina Harper, Paul Harrison, Stephen C. Watts, Ben Adler, Priyangi A. Alwis, Mark Prescott, Deanna Deveson Lucas, Alexandra Dimitropoulos

Publikováno v: BMC Genomics

Background Burkholderia pseudomallei is the causative agent of melioidosis, a severe invasive disease of humans and animals. Initial screening of a B. pseudomallei signature-tagged mutagenesis library identified an attenuated mutant with a transposon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be792c0e2606dfad9929ec6aeec9418

Systematic mutagenesis of genes encoding predicted autotransported proteins of Burkholderia pseudomallei identifies factors mediating virulence in mice, net intracellular replication and a novel protein conferring serum resistance.

Autor: Natalie R Lazar Adler, Mark P Stevens, Rachel E Dean, Richard J Saint, Depesh Pankhania, Joann L Prior, Timothy P Atkins, Bianca Kessler, Arnone Nithichanon, Ganjana Lertmemongkolchai, Edouard E Galyov

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0121271 (2015)

Burkholderia pseudomallei is the causative agent of the severe tropical disease melioidosis, which commonly presents as sepsis. The B. pseudomallei K96243 genome encodes eleven predicted autotransporters, a diverse family of secreted and outer membra

Externí odkaz: https://doaj.org/article/91804450bb5c4f8d8ff972a17b41c5e0