Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Natalie Porat-Shliom"'
Autor:
Sun Woo Sophie Kang, Rory P. Cunningham, Colin B. Miller, Lauryn A. Brown, Constance M. Cultraro, Adam Harned, Kedar Narayan, Jonathan Hernandez, Lisa M. Jenkins, Alexei Lobanov, Maggie Cam, Natalie Porat-Shliom
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract In the liver, mitochondria are exposed to different concentrations of nutrients due to their spatial positioning across the periportal and pericentral axis. How the mitochondria sense and integrate these signals to respond and maintain homeo
Externí odkaz:
https://doaj.org/article/2c66b12c825b487c840eeb96a8179b89
Autor:
Suehelay Acevedo‐Acevedo, Megan L. Stefkovich, Sun Woo Sophie Kang, Rory P. Cunningham, Constance M. Cultraro, Natalie Porat‐Shliom
Publikováno v:
Hepatology Communications, Vol 6, Iss 8, Pp 1949-1961 (2022)
Abstract As important as the fasting response is for survival, an inability to shut it down once nutrients become available can lead to exacerbated disease and severe wasting. The liver is central to transitions between feeding and fasting states, wi
Externí odkaz:
https://doaj.org/article/bb5bf387770e43c08d2c39b8e7b37765
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Despite the ever-increasing prevalence of non-alcoholic fatty liver disease (NAFLD), the etiology and pathogenesis remain poorly understood. This is due, in part, to the liver’s complex physiology and architecture. The liver maintains glucose and l
Externí odkaz:
https://doaj.org/article/3a0bd493fac34de69b3dab4d780df6bf
Publikováno v:
iScience, Vol 11, Iss , Pp 440-449 (2019)
Summary: Mitochondria are dynamic organelles undergoing fission, fusion, and translocation. These processes have been studied in cultured cells; however, little is known about their regulation in cells within tissues in vivo. We applied four-dimensio
Externí odkaz:
https://doaj.org/article/e77cdf20ddce4066bf6e1a3a993793c6
Autor:
Natalie Porat-Shliom, Yun Chen, Muhibullah Tora, Akiko Shitara, Andrius Masedunskas, Roberto Weigert
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 514-521 (2014)
Little is known about the spatiotemporal coordination of mitochondrial metabolism in multicellular organisms in situ. Using intravital microscopy in live animals, we report that mitochondrial metabolism undergoes rapid and periodic oscillations under
Externí odkaz:
https://doaj.org/article/ca25584e67cd4911804a767b297059f6
Publikováno v:
Cells, Vol 1, Iss 4, Pp 1121-1132 (2012)
Intravital microscopy has enabled imaging of the dynamics of subcellular structures in live animals, thus opening the door to investigating membrane trafficking under physiological conditions. Here, we sought to determine whether the architecture and
Externí odkaz:
https://doaj.org/article/aeae813dca024ca0a32cf1ccbc2bd70f
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81987 (2013)
Clathrin-independent endocytosis (CIE) is a form of bulk plasma membrane (PM) endocytosis that allows cells to sample and evaluate PM composition. Once in endosomes, the internalized proteins and lipids can be recycled back to the PM or delivered to
Externí odkaz:
https://doaj.org/article/74ea246b82af4bd99b78a7ec6dbe3726
Autor:
M Pilar Pedro, Katherine Lund, Sun Woo Sophie Kang, Ting Chen, Christina H Stuelten, Natalie Porat-Shliom, Ramiro Iglesias-Bartolome
Publikováno v:
bioRxiv
Epithelial cells in the skin and other tissues rely on signals from their environment to maintain homeostasis and respond to injury, and G protein-coupled receptors (GPCRs) play a critical role in this communication. A better understanding of the GPC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d742c5ac41ac7b1d5773d4fce79f5cc
https://doi.org/10.1101/2023.05.30.542853
https://doi.org/10.1101/2023.05.30.542853
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Tumor heterogeneity is a hallmark of cancer but a challenging problem to dissect mechanistically. Less recognized is that cells within normal tissues are also remarkably diverse. Hepatocytes are a great example because their spatial positioning and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6108f77d47ee025630000c7e2db535f5
https://europepmc.org/articles/PMC10010932/
https://europepmc.org/articles/PMC10010932/
Autor:
Pedro Gonzalez-Menendez, Ira Phadke, Meagan E Olive, Axel Joly, Julien Papoin, Hongxia Yan, Jérémy Galtier, Jessica Platon, Sun Woo Sophie Kang, Kathy L. McGraw, Marie Daumur, Marie Pouzolles, Taisuke Kondo, Stéphanie Boireau, Franciane Paul, David J Young, Sylvain Lamure, Raghavendra G Mirmira, Anu Narla, Guillaume Cartron, Cynthia E. Dunbar, Myriam Boyer-Clavel, Natalie Porat-Shliom, Valerie Dardalhon, Valerie S Zimmermann, Marc Sitbon, Thomas Dever, Narla Mohandas, Lydie M Da Costa, Namrata D. Udeshi, Lionel Blanc, Sandrina Kinet, Naomi Taylor
Publikováno v:
Blood.
Metabolic programs contribute to hematopoietic stem and progenitor cell (HSPC) fate, but it is not known whether the metabolic regulation of protein synthesis controls HSPC differentiation. Here, we show that SLC7A1/CAT1-dependent arginine uptake and