Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Natalie P Smithers"'
Autor:
Salvatore Montesanto, Natalie P Smithers, Fabio Bucchieri, Valerio Brucato, Vincenzo La Carrubba, Donna E Davies, Franco Conforti
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210830 (2019)
Development of biocompatible and functional scaffolds for tissue engineering is a major challenge, especially for development of polarised epithelia that are critical structures in tissue homeostasis. Different in vitro models of the lung epithelial
Externí odkaz:
https://doaj.org/article/f4319136e5d94e239c5b77ff2718306f
Autor:
Grissel Faura Tellez, Brigitte W M Willemse, Uilke Brouwer, Susan Nijboer-Brinksma, Karl Vandepoele, Jacobien A Noordhoek, Irene Heijink, Maaike de Vries, Natalie P Smithers, Dirkje S Postma, Wim Timens, Laura Wiffen, Frans van Roy, John W Holloway, Peter M Lackie, Martijn C Nawijn, Gerard H Koppelman
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163967 (2016)
The asthma gene PCDH1 encodes Protocadherin-1, a putative adhesion molecule of unknown function expressed in the airway epithelium. Here, we characterize the localization, differential expression, homotypic adhesion specificity and function of PCDH1
Externí odkaz:
https://doaj.org/article/ef0770c4af6a47bb9bd673678b5912d4
Autor:
Matthew Loxham, Donna E. Davies, Flemming R. Cassee, Christopher H. Woelk, Graham Packham, Natalie P. Smithers, Alison Yeomans, Jeongmin Woo, Alina M Crainic, Akul Singhania, Richard Cook
Airborne particulate matter (PM) is a leading cause of mortality and morbidity. However, understanding of the range and mechanisms of effects of PM components is poor. PM generated in underground railways is rich in metals, especially iron. In the ul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50c75d14f110b069dd74a937568c24f
http://hdl.handle.net/10029/623824
http://hdl.handle.net/10029/623824
Autor:
Matthew Loxham, Alison Yeomans, Richard Cook, Graham Packham, Flemming R. Cassee, Christopher H. Woelk, Natalie P. Smithers, Donna E. Davies, Akul Singhania, Jeongmin Woo, Alina M Crainic
Publikováno v:
Occupational and Environmental Health.
Background: In underground railways, airborne particulate matter (PM) concentrations are significantly elevated compared to outdoors. Underground PM is especially rich in iron and transition metals; in the ultrafine fraction (UFPM; diameter Aim: To a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d4ba4e8479f43ff6b476cbcaae26c72
https://doi.org/10.1183/23120541.lungscienceconference-2019.op02
https://doi.org/10.1183/23120541.lungscienceconference-2019.op02
Publikováno v:
European Respiratory Journal, 45(6), 1745-1748. EUROPEAN RESPIRATORY SOC JOURNALS LTD
Inhibition of Pim1 kinase activity reduces viral replication by inducing the onset of bronchial epithelial cell death http://ow.ly/IJWGD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b0904b640bd5dd438ad554c1c27470
https://research.rug.nl/en/publications/a6367b82-ac32-4371-8974-7a6ec640464d
https://research.rug.nl/en/publications/a6367b82-ac32-4371-8974-7a6ec640464d
Autor:
Valerio Brucato, Donna E. Davies, Salvatore Montesanto, Vincenzo La Carrubba, Franco Conforti, Natalie P. Smithers, Fabio Bucchieri
Publikováno v:
3.2 Airway Cell Biology and Immunopathology.
Aims: Investigation of epithelial barrier formation using PLLA membranes for application in bioengineering. Background: The development of functional and biocompatible substitutes for damaged tissue or organs is a major challenge in biomedical engine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6327a7fcd88f140d1d3bd9755a123d
https://doi.org/10.1183/13993003.congress-2016.pa3994
https://doi.org/10.1183/13993003.congress-2016.pa3994
Autor:
Patrick Dennison, Matthew J. Edwards, Peter H. Howarth, Emily J. Swindle, Cornelia Blume, Hitasha Rupani, Kamran Tariq, Alison R Hill, Jessica Donaldson, Donna E. Davies, Liku B. Tezera, Natalie P. Smithers, Christopher Grainge
Publikováno v:
Tissue Barriers
The bronchial epithelium and underlying fibroblasts form an epithelial mesenchymal trophic unit (EMTU) which controls the airway microenvironment. We hypothesised that cell-cell communication within the EMTU propagates and amplifies the innate immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737dd48199b7fc15739484a618aeaa9a
https://eprints.soton.ac.uk/398588/
https://eprints.soton.ac.uk/398588/
Publikováno v:
Biochemistry
We show that interactions of fatty acids with the central cavity of potassium channel KcsA can be characterized using the fluorescence probe 11-dansylaminoundecanoic acid (Dauda). The fluorescence emission spectrum of Dauda bound to KcsA in bilayers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d4d3cbc7ef3b85532677814ec4b806
https://doi.org/10.1021/bi3009196
https://doi.org/10.1021/bi3009196
Autor:
Nicole Bedke, Donna E. Davies, Natalie P. Smithers, Matthew Loxham, Maaike de Vries, Martijn C. Nawijn, Peter H. Howarth
Publikováno v:
European Respiratory Journal, 47(3), 783-791. EUROPEAN RESPIRATORY SOC JOURNALS LTD
Therapeutic options to treat virus-induced asthma exacerbations are limited and urgently needed. Therefore, we tested Pim1 kinase as potential therapeutic target in human rhinovirus (HRV) infections. We hypothesised that inhibition of Pim1 kinase red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1a05e5e2374171fd9ddf256998d75e
https://pubmed.ncbi.nlm.nih.gov/26869670
https://pubmed.ncbi.nlm.nih.gov/26869670
Autor:
Maïwenn Beaugrand, Maurits R.R. de Planque, Natalie P. Smithers, Hywel Morgan, Isabelle Marcotte, Mark S. Friddin, Philip T. F. Williamson
Single-channel electrophysiology with lipid bilayer systems requires ion channel expression, purification from cell culture, and reconstitution in proteoliposomes for delivery to a planar bilayer. Here we demonstrate that single-channel current measu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a32502c6460a3d0722c267876b22e0
https://eprints.soton.ac.uk/359046/
https://eprints.soton.ac.uk/359046/