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Preemptive CD20+ B cell Depletion Attenuates Cardiac Allograft Vasculopathy in CD154-Treated Monkeys
Autor:
Richard N. Pierson, Xiangfei Cheng, Anthony Kronfli, C. Avon, Mitch Higuchi, Agnes M. Azimzadeh, Stuart L. Mitchell, Shahrooz S. Kelishadi, Alena Hershfeld, Natalie OʼNeill, E. Rybak, Guosheng Wu, T. Stoddard, E. Welty, Tianshu Zhang, Bao-Ngoc H. Nguyen, Lars Burdorf
Publikováno v:
Transplantation. 101:63-73
Anti-CD154 monotherapy is associated with antidonor allo-antibody (Ab) elaboration, cardiac allograft vasculopathy (CAV), and allograft failure in preclinical primate cell and organ transplant models. In the context of calcineurin inhibitors (CNI), t