Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Natalie M. Edner"'
Autor:
Natalie M. Edner, Luke P. Houghton, Elisavet Ntavli, Chloe Rees-Spear, Lina Petersone, Chunjing Wang, Astrid Fabri, Yassin Elfaki, Andrea Rueda Gonzalez, Rachel Brown, Kai Kisand, Pärt Peterson, Laura E. McCoy, Lucy S. K. Walker
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Circulating follicular helper T cells (cTfh) can show phenotypic alterations in disease settings, including in the context of tissue-damaging autoimmune or anti-viral responses. Using severe COVID-19 as a paradigm of immune dysregulation, we have exp
Externí odkaz:
https://doaj.org/article/e691596e5a1945598aa5b7e47fe61d36
Autor:
Chun Jing Wang, Lina Petersone, Natalie M. Edner, Frank Heuts, Vitalijs Ovcinnikovs, Elisavet Ntavli, Alexandros Kogimtzis, Astrid Fabri, Yassin Elfaki, Luke P. Houghton, Ralf J. Hosse, David A. Schubert, Andreas P. Frei, Ellen M. Ross, Lucy S. K. Walker
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract Blockade of CD28 costimulation with CTLA-4-Ig/Abatacept is used to dampen effector T cell responses in autoimmune and transplantation settings. However, a significant drawback of this approach is impaired regulatory T cell homeostasis that r
Externí odkaz:
https://doaj.org/article/88fdb72320aa489eb09cc8536ed4b458
Autor:
Chun Jing Wang, Lina Petersone, Natalie M. Edner, Frank Heuts, Vitalijs Ovcinnikovs, Elisavet Ntavli, Alexandros Kogimtzis, Astrid Fabri, Yassin Elfaki, Luke P. Houghton, Ralf J. Hosse, David A. Schubert, Andreas P. Frei, Ellen M. Ross, Lucy S. K. Walker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/bb4af0f8c0874ff3af8a19e29e105ca1
Autor:
Lina Petersone, Natalie M. Edner, Vitalijs Ovcinnikovs, Frank Heuts, Ellen M. Ross, Elisavet Ntavli, Chun J. Wang, Lucy S. K. Walker
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Co-ordinated interaction between distinct cell types is a hallmark of successful immune function. A striking example of this is the carefully orchestrated cooperation between helper T cells and B cells that occurs during the initiation and fine-tunin
Externí odkaz:
https://doaj.org/article/a0edfa3c98b64d6e92fe1077110a0a54
Autor:
Natalie M Edner, Elisavet Ntavli, Lina Petersone, Chun Jing Wang, Astrid Fabri, Alexandros Kogimtzis, Vitalijs Ovcinnikovs, Ellen M Ross, Frank Heuts, Yassin Elfaki, Luke P Houghton, Toby Talbot, Amna Sheri, Alexandra Pender, David Chao, Lucy S K Walker
Publikováno v:
Immunotherapy Advances. 3
SummaryEfficacy of checkpoint inhibitor therapies in cancer varies greatly, with some patients showing complete responses while others do not respond and experience progressive disease. We aimed to identify correlates of response and progression foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::181b75d72a506e20a2f7a7b21e117e9a
https://doi.org/10.1093/immadv/ltad001
https://doi.org/10.1093/immadv/ltad001
Publikováno v:
Immunotherapy advances. 1(1)
Summary Curbing unwanted T cell responses by costimulation blockade has been a recognised immunosuppressive strategy for the last 15 years. However, our understanding of how best to deploy this intervention is still evolving. A key challenge has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c3bda0bf868d8b01e6e090fb29e39c
https://pubmed.ncbi.nlm.nih.gov/36017489
https://pubmed.ncbi.nlm.nih.gov/36017489
Publikováno v:
Nature Reviews Drug Discovery. 19:860-883
Therapeutic targeting of immune checkpoints has garnered significant attention in the area of cancer immunotherapy, in which efforts have focused in particular on cytotoxic T lymphocyte antigen 4 (CTLA4) and PD1, both of which are members of the CD28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01e38726c888c009aa385a77c4a0b0f6
https://doi.org/10.1038/s41573-020-0081-9
https://doi.org/10.1038/s41573-020-0081-9
Autor:
Lina Petersone, Chun Jing Wang, Ellen M. Ross, Martin Eichmann, Elisavet Ntavli, Alexandros Kogimtzis, Frank Heuts, Rupert Kenefeck, Natalie M. Edner, Niclas Thomas, Mark Peakman, Roman Baptista, Miranda Rosenthal, Yassin Elfaki, Lutz Jermutus, Lucy S. K. Walker, Vitalijs Ovcinnikovs, Philip Ambery
Publikováno v:
Nature Immunology. 21:1244-1255
Follicular helper T (TFH) cells are implicated in type 1 diabetes (T1D), and their development has been linked to CD28 costimulation. We tested whether TFH cells were decreased by costimulation blockade using the CTLA-4–immunoglobulin (Ig) fusion p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54bedb5eca58d2d9c16a6a91691e585d
https://doi.org/10.1038/s41590-020-0744-z
https://doi.org/10.1038/s41590-020-0744-z
Publikováno v:
Proceedings of the National Academy of Sciences. 117:7971-7980
Timely resolution of bacterial infections critically depends on phagocytosis of invading pathogens by polymorphonuclear neutrophil granulocytes (PMNs), followed by PMN apoptosis and efferocytosis. Here we report that bacterial DNA (CpG DNA) and mitoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e56523ab7eb10f903967f9305c18a25
https://doi.org/10.1073/pnas.1920193117
https://doi.org/10.1073/pnas.1920193117
Autor:
Chun Jing Wang, Lina Petersone, Natalie M. Edner, Frank Heuts, Vitalijs Ovcinnikovs, Elisavet Ntavli, Alexandros Kogimtzis, Astrid Fabri, Yassin Elfaki, Luke P. Houghton, Ralf J. Hosse, David A. Schubert, Andreas P. Frei, Ellen M. Ross, Lucy S. K. Walker
Publikováno v:
Nature communications. 13(1)
Blockade of CD28 costimulation with CTLA-4-Ig/Abatacept is used to dampen effector T cell responses in autoimmune and transplantation settings. However, a significant drawback of this approach is impaired regulatory T cell homeostasis that requires C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75c7f0bdfd939f11cca2c104e67598d
https://pubmed.ncbi.nlm.nih.gov/36347877
https://pubmed.ncbi.nlm.nih.gov/36347877