Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Natalie M Kirk"'
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
ABSTRACTAnimal models that can replicate clinical and pathologic features of severe human coronavirus infections have been instrumental in the development of novel vaccines and therapeutics. The goal of this review is to summarize our current underst
Externí odkaz:
https://doaj.org/article/79c65640d92842e8ace1702aaeed6a22
Autor:
Brendan K Podell, David F Ackart, Natalie M Kirk, Sarah P Eck, Christopher Bell, Randall J Basaraba
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46824 (2012)
Hyperglycemia, the diagnostic feature of diabetes also occurs in non-diabetics associated with chronic inflammation and systemic insulin resistance. Since the increased risk of active TB in diabetics has been linked to the severity and duration of hy
Externí odkaz:
https://doaj.org/article/25adbd799c8a441c983c046e41a137eb
Autor:
Gopinath S Palanisamy, Natalie M Kirk, David F Ackart, Andrés Obregón-Henao, Crystal A Shanley, Ian M Orme, Randall J Basaraba
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34148 (2012)
The typical host response to infection of humans and some animals by M. tuberculosis is the accumulation of reactive oxygen species generating inflammatory cells into discrete granulomas, which frequently develop central caseous necrosis. In previous
Externí odkaz:
https://doaj.org/article/70494065d5ad4bb6ad2dd0a766bce4e3
Autor:
Gopinath S Palanisamy, Natalie M Kirk, David F Ackart, Crystal A Shanley, Ian M Orme, Randall J Basaraba
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26254 (2011)
The development of granulomatous inflammation with caseous necrosis is an important but poorly understood manifestation of tuberculosis in humans and some animal models. In this study we measured the byproducts of oxidative stress in granulomatous le
Externí odkaz:
https://doaj.org/article/93f7bf8bdb5c42aa9219efda9820fa1e
Autor:
Shamim Ahmed, Durgadevi Parthasarathy, Rachael Newhall, Tashina Picard, Morgainne Aback, Sneha Ratnapriya, William Arndt, Widaliz Vega-Rodriguez, Natalie M. Kirk, Yuying Liang, Alon Herschhorn
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract An effective human immunodeficiency virus type I (HIV-1) vaccine that robustly elicits broadly neutralizing antibodies (bnAbs) against HIV-1 envelope glycoproteins (Envs) to block viral entry is still not available. Thus, identifying trigger
Externí odkaz:
https://doaj.org/article/b0bfdd08ba3f43279f53917824cf0464
Publikováno v:
Pathogens, Vol 13, Iss 1, p 35 (2023)
Animal models are essential for studying disease pathogenesis and to test the efficacy and safety of new vaccines and therapeutics. For most diseases, there is no single model that can recapitulate all features of the human condition, so it is vital
Externí odkaz:
https://doaj.org/article/3c3898e8db484f2196a8947dd0e00dab
Autor:
Natalie M. Kirk, Qinfeng Huang, Sophia Vrba, Mizanur Rahman, Alisha M. Block, Hannah Murphy, Dylan W. White, Sarah B. Namugenyi, Hinh Ly, Anna D. Tischler, Yuying Liang
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionTuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains a major global health threat. The only available vaccine Bacille Calmette-Guérin (BCG) does not prevent adult pulmonary TB. New effective TB vaccines should aim to stim
Externí odkaz:
https://doaj.org/article/fc54f3337c324bcbbed618a067e3197a
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2021)
Objective: To identify the effect of glutathione (GSH) on cell survival in a novel in vitro model of itraconazole (ITZ)-associated hepatotoxicity using canine primary hepatocytes.Sample: Commercially sourced, cryopreserved male dog (Beagle) primary h
Externí odkaz:
https://doaj.org/article/1a9549f1bbf440dfb74d861f6b71f9f8
Publikováno v:
Vaccines, Vol 8, Iss 4, p 680 (2020)
Vaccination is arguably the most cost-effective preventative measure against infectious diseases. While vaccines have been successfully developed against certain viruses (e.g., yellow fever virus, polio virus, and human papilloma virus HPV), those ag
Externí odkaz:
https://doaj.org/article/1ef653634e254b9db5bcc000675de335
Publikováno v:
J Vet Diagn Invest
Two aborted Chester White pig fetuses were presented to a veterinary diagnostic laboratory in Illinois. Postmortem examination identified no gross abnormalities. Histologic evaluation revealed multifocal necrosis of chorionic epithelial cells, coales
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ebf5e9346c1f93b27b61d5b958116d
https://europepmc.org/articles/PMC8689021/
https://europepmc.org/articles/PMC8689021/
