Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons

Autor: Farid N Garas, Rahul S Shah, Eszter Kormann, Natalie M Doig, Federica Vinciati, Kouichi C Nakamura, Matthijs C Dorst, Yoland Smith, Peter J Magill, Andrew Sharott

Publikováno v: eLife, Vol 5 (2016)

Corticostriatal afferents can engage parvalbumin-expressing (PV+) interneurons to rapidly curtail the activity of striatal projection neurons (SPNs), thus shaping striatal output. Schemes of basal ganglia circuit dynamics generally consider striatal

Externí odkaz: https://doaj.org/article/47215ca2f5fb4805a7fea1929266cda8

Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility

Autor: Polina Kosillo, Natalie M. Doig, Kamran M. Ahmed, Alexander H.C.W. Agopyan-Miu, Corinna D. Wong, Lisa Conyers, Sarah Threlfell, Peter J. Magill, Helen S. Bateup

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)

Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 or TSC2 genes, which negatively regulate mTORC1 signalling. Here the authors selectively delete Tsc1 from dopamine neurons in mice and find impairments

Externí odkaz: https://doaj.org/article/8f206497b65e4d93a92d89d476e37c28

Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior

Autor: Benjamin H.M. Hunn, Siv Vingill, Sarah Threlfell, Javier Alegre-Abarrategui, Morgane Magdelyns, Thierry Deltheil, Nora Bengoa-Vergniory, Peter L. Oliver, Milena Cioroch, Natalie M. Doig, David M. Bannerman, Stephanie J. Cragg, Richard Wade-Martins

Publikováno v: Cell Reports, Vol 29, Iss 4, Pp 920-931.e7 (2019)

Summary: Parkinson’s disease (PD) is characterized by the death of dopamine neurons in the substantia nigra pars compacta (SNc) and accumulation of α-synuclein. Impaired autophagy has been implicated and activation of autophagy proposed as a treat

Externí odkaz: https://doaj.org/article/173e703e2233467d9c3680e7a98ca772

GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model

Autor: Ruth E. Siddorn, Katherine R. Brimblecombe, Emanuel F. Lopes, Nicholas Pasternack, Peter J. Magill, Richard Wade-Martins, Sarah Threlfell, Nora Bengoa-Vergniory, Natalie Connor-Robson, Natalie M. Doig, Bradley M. Roberts, Stephanie J. Cragg

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications

Striatal dopamine (DA) is critical for action and learning. Recent data show that DA release is under tonic inhibition by striatal GABA. Ambient striatal GABA tone on striatal projection neurons can be determined by plasma membrane GABA uptake transp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb111576fd5377bcd50d1b23709f72f
https://orca.cardiff.ac.uk/id/eprint/142157/1/s41467-020-18247-5.pdf

A hippocampus-accumbens tripartite neuronal motif guides appetitive memory in space

Autor: Natalie M. Doig, Pavel V Perestenko, Tommas J. Ellender, David Dupret, Stéphanie Trouche, Vítor Lopes-dos-Santos, Peter J. Magill, Mohamady El-Gaby, Vadim Koren, Farid N. Garas, Andrew Sharott, Hayley M. Reeve

Publikováno v: Cell
Trouche, S, Koren, V, Doig, N M, Ellender, T J, El-Gaby, M, Lopes-Dos-Santos, V, Reeve, H M, Perestenko, P V, Garas, F N, Magill, P J, Sharott, A & Dupret, D 2019, ' A Hippocampus-Accumbens Tripartite Neuronal Motif Guides Appetitive Memory in Space ', Cell, vol. 176, no. 6, pp. 1393-1406.e16 . https://doi.org/10.1016/j.cell.2018.12.037

Summary Retrieving and acting on memories of food-predicting environments are fundamental processes for animal survival. Hippocampal pyramidal cells (PYRs) of the mammalian brain provide mnemonic representations of space. Yet the substrates by which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072241c25659e6049787a9dc377d2219
http://ora.ox.ac.uk/objects/uuid: