Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Natalie Lo"'
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113845- (2024)
Summary: Poly(ADP-ribosyl)ation (PARylation), catalyzed mainly by poly(ADP-ribose) polymerase (PARP)1, is a key posttranslational modification involved in DNA replication and repair. Here, we report that TIMELESS (TIM), an essential scaffold of the r
Externí odkaz:
https://doaj.org/article/ae9ca411df6643539036298289895f18
Autor:
Julie Rageul, Jennifer J. Park, Ping Ping Zeng, Eun-A Lee, Jihyeon Yang, Sunyoung Hwang, Natalie Lo, Alexandra S. Weinheimer, Orlando D. Schärer, Jung-Eun Yeo, Hyungjin Kim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The fork protection complex (FPC), including the proteins TIMELESS and TIPIN, stabilizes the replisome to ensure unperturbed fork progression during DNA replication. Here the authors reveal that that SDE2, a PCNA-associated protein, plays an importan
Externí odkaz:
https://doaj.org/article/cf4354514492419cabdbc66606aed2dc
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 1 (2021)
The fork protection complex (FPC), comprising the TIMELESS (TIM)-TIPIN heterodimer, acts as a scaffold of the replisome to support seamless DNA replication. We recently showed that SDE2, a PCNA-associated DNA replication stress regulator, maintains t
Externí odkaz:
https://doaj.org/article/93f18177877144fd95aef61410d1a305
Autor:
Alexandra S. Weinheimer, YiTing Paung, Julie Rageul, Arafat Khan, Natalie Lo, Brian Ho, Michael Tong, Sébastien Alphonse, Markus A. Seeliger, Hyungjin Kim
Publikováno v:
The Journal of biological chemistry. 298(8)
Elevated DNA replication stress causes instability of the DNA replication fork and increased DNA mutations, which underlies tumorigenesis. The DNA replication stress regulator silencing-defective 2 (SDE2) is known to bind to TIMELESS (TIM), a protein
Autor:
Anne Walling, Lisa Soleymani Lehmann, Scott Shreve, Karleen F. Giannitrapani, Karl A. Lorenz, Jill Lowery, David B. Bekelman, Natalie Lo, Marie C. Haverfield, Cati Brown-Johnson, Mary Beth Foglia
Publikováno v:
Journal of Pain and Symptom Management. 61:262-269
Context The Veterans Health Administration (VA) National Center for Ethics in Healthcare implemented the Life-Sustaining Treatment Decisions Initiative, including policy and practice standards, clinician communication training, a documentation templa
Autor:
Martin Grosshans, Torsten Paul, Sebastian Karl Maximilian Fischer, Natalie Lotzmann, Hannah List, Christina Haag, Jochen Mutschler
Publikováno v:
Frontiers in Public Health, Vol 12 (2024)
Artificial intelligence (AI) offers a wealth of opportunities for medicine, if we also bear in mind the risks associated with this technology. In recent years the potential future integration of AI with medicine has been the subject of much debate, a
Externí odkaz:
https://doaj.org/article/42102a62cad14a72b2dc418786bb86ab
Autor:
Natalie Lorenz, Reuben McGregor, Alana L. Whitcombe, Prachi Sharma, Ciara Ramiah, Francis Middleton, Michael G. Baker, William J. Martin, Nigel J. Wilson, Amy W. Chung, Nicole J. Moreland
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110558- (2024)
Summary: Understanding the immune profile of acute rheumatic fever (ARF), a serious post-infectious sequelae of Streptococcal pyogenes (group A Streptococcus [GAS]), could inform disease pathogenesis and management. Circulating cytokines, immunoglobu
Externí odkaz:
https://doaj.org/article/b13c75f917df48d4a74aa75b9fe44bec
Autor:
Sada M. Boyd, Sara Freimuth, Carolyn Xue, Brandon Lyons, Sana Nagori, Michael Yu, Natalie Lozano-Huntelman, Eleanor S. Diamant, Pamela J. Yeh
Publikováno v:
Frontiers in Communication, Vol 9 (2024)
IntroductionThe media can play a vital role in determining to what extent the general public understands scientific concepts. The understanding and acceptance of evolution are often influenced by factors beyond scientific knowledge alone, including e
Externí odkaz:
https://doaj.org/article/643492fa6b5c49aba0e6c0338116ad96
Autor:
Marie C. Haverfield, Ariadna Garcia, Karleen F. Giannitrapani, Anne Walling, Joseph Rigdon, David B. Bekelman, Natalie Lo, Lisa S. Lehmann, Josephine Jacobs, Natalia Festa, Karl A. Lorenz
Publikováno v:
Journal of pain and symptom management. 63(4)
The Life Sustaining Treatment Decision Initiative is a national effort by the Veterans Health Administration to ensure goals of care documentation occurs among all patients at high risk of life-threatening events.Examine likelihood to receive goals o
Autor:
Marie C. Haverfield, Jill Lowery, Jessica Ma, Karleen F. Giannitrapani, Cati Brown-Johnson, Natalie Lo, Mary Beth Foglia, David B. Bekelman, Anne Walling, Karl A. Lorenz
Publikováno v:
Palliative medicine. 35(8)
Background: The United States Veterans Health Administration National Center for Ethics in Health Care implemented the Life-Sustaining Treatment Decisions Initiative throughout the Veterans Health Administration health care system in 2017. This polic