Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Natalie Lefort"'
Publikováno v:
Journal of Nutritional Science, Vol 5 (2016)
Enrichment of tissues with ≥20-carbon n-3 PUFA like EPA is associated with positive cardiovascular outcomes. Stearidonic acid (SDA; 18 : 4n-3) and α-linolenic acid (ALA; 18 : 3n-3) are plant-derived dietary n-3 PUFA; however, direct comparisons of
Externí odkaz:
https://doaj.org/article/09e037ea7dab4a499ea273ec9f7d9063
Publikováno v:
Nutrients, Vol 9, Iss 3, p 261 (2017)
Buglossoides arvensis (Ahiflower) oil is a dietary oil rich in stearidonic acid (20% SDA; 18:4 n-3). The present randomized, double blind, placebo-controlled clinical trial investigated the effects of three Ahiflower oil dosages on omega-3 polyunsatu
Externí odkaz:
https://doaj.org/article/fd008fc32a4a4c07b0dea3ed2334523b
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids. 138:38-44
5-lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into pro-inflammatory leukotrienes. N-3 PUFA like eicosapentaenoic acid are subject to a similar metabolism and are precursors of pro-resolving mediators. Stearidonic acid (18:4
Autor:
Vett K. Lloyd, Mohamed Touaibia, Adrian S. Culf, Natalie Lefort, Amy N. Brown, Rodney J. Ouellette, Miroslava Cuperlovic-Culf
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 93:77-85
Metabolomics analysis was used to determine the effect of two well known, non-proprietary metabolic modulators, dichloroacetate and allopurinol on breast cancer cell lines. Dichloroacetate, a pyruvate dehydrogenase kinase inhibitor and allopurinol, a
Publikováno v:
Ecotoxicology and environmental safety.
In Atlantic Canada and other salmon-growing regions, treatment of sea lice infestations in salmon aquaculture is necessary to protect fish health. The product Salmosan®, which contains the organophosphate azamethiphos as the active ingredient, is a
Publikováno v:
Future Oncology. 8:1315-1330
The metabolism of tumors is remarkably different from the metabolism of corresponding normal cells and tissues. Metabolic alterations are initiated by oncogenes and are required for malignant transformation, allowing cancer cells to resist some cell
Autor:
Muhammad A. Abdul-Ghani, Ralph A. DeFronzo, Holly Van Remmen, Nicolas Musi, Sangeeta Ghosh, Benjamin P. Bowen, Joaquin Joya-Galeana, Natalie Lefort, Lawrence J. Mandarino, Raweewan Lertwattanarak, Arlan Richardson, Marjorie Molina-Carrion, José de Jesús Garduño-García
Publikováno v:
Diabetes
OBJECTIVE Aging increases the risk of developing impaired glucose tolerance (IGT) and type 2 diabetes. It has been proposed that increased reactive oxygen species (ROS) generation by dysfunctional mitochondria could play a role in the pathogenesis of
Autor:
Heather A. Bimonte-Nelson, Alexandra N. Garcia, Alain R. Simard, B. Blair Braden, Stephanie R. Villa, Natalie Lefort, Sarah E. Mennenga, Jazmin I. Acosta, Laszlo Prokai
Publikováno v:
Psychopharmacology. 218:405-418
The synthetic progestin medroxyprogesterone acetate (MPA), widely used in hormone therapy (HT) and as the contraceptive Depo Provera, is implicated in detrimental cognitive effects in women. Recent evidence in aged ovariectomized (Ovx) rodents shows
Autor:
Natalie Lefort, Christian Meyer, Charles R. Flynn, Kurt Højlund, Hyonson Hwang, Lawrence J. Mandarino, Zhengping Yi, Christopher C. Smoke, Christine Roberts, Benjamin P. Bowen, Elena A. De Filippis
Publikováno v:
Diabetes
Hwang, H, Bowen, B P, Lefort, N, Flynn, C R, De Filippis, E A, Roberts, C, Smoke, C C, Meyer, C, Højlund, K, Yi, Z & Mandarino, L J 2010, ' Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes ', Diabetes, vol. 59, no. 1, pp. 33-42 . https://doi.org/10.2337/db09-0214
Hwang, H, Bowen, B P, Lefort, N, Flynn, C R, De Filippis, E A, Roberts, C, Smoke, C C, Meyer, C, Højlund, K, Yi, Z & Mandarino, L J 2010, ' Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes ', Diabetes, vol. 59, no. 1, pp. 33-42 . https://doi.org/10.2337/db09-0214
OBJECTIVE Insulin resistance in skeletal muscle is an early phenomenon in the pathogenesis of type 2 diabetes. Studies of insulin resistance usually are highly focused. However, approaches that give a more global picture of abnormalities in insulin r
Autor:
Zhengping Yi, Paul R. Langlais, Natalie Lefort, Christine Y. Christ-Roberts, Hyonson Hwang, Elena A. De Filippis, Moulun Luo, Lawrence J. Mandarino
Publikováno v:
Endocrinology. 148:4895-4905
The function of insulin receptor substrate-1 (IRS-1) is regulated by both tyrosine and serine/threonine phosphorylation. Phosphorylation of some serine/threonine residues in IRS-1 dampens insulin signaling, whereas phosphorylation of other serine/thr