A Small-Angle Neutron Scattering, Calorimetry and Densitometry Study to Detect Phase Boundaries and Nanoscale Domain Structure in a Binary Lipid Mixture

Autor: Natalie Krzyzanowski, Lionel Porcar, Ursula Perez-Salas

Publikováno v: Membranes, Vol 13, Iss 3, p 323 (2023)

Techniques that can probe nanometer length scales, such as small-angle neutron scattering (SANS), have become increasingly popular to detect phase separation in membranes. But to extract the phase composition and domain structure from the SANS traces

Externí odkaz: https://doaj.org/article/941ed816b9ce487ba163cdac581f2a90

Influence of the membrane environment on cholesterol transfer

Autor: Ursula Perez-Salas, Jeffrey Michael Breidigan, Natalie Krzyzanowski, Yangmingyue Liu, Lionel Porcar

Publikováno v: 'Journal of Lipid Research ', vol: 58, pages: 2255-2263 (2017)
Journal of Lipid Research
Journal of Lipid Research, Vol 58, Iss 12, Pp 2255-2263 (2017)

Cholesterol, an essential component in biological membranes, is highly unevenly distributed within the cell, with most localized in the plasma membrane while only a small fraction is found in the endoplasmic reticulum, where it is synthesized. Cellul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d03ee4d92a392c616e2fed653c5732b
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ILL:26980

Cholesterol solubility limit in lipid membranes probed by small angle neutron scattering and MD simulations

Autor: Natalie Krzyzanowski, Sumit Garg, Lionel Porcar, Paul Butler, Francisco Castro-Roman, Ursula Perez-Salas, Pedro Jesus Bautista

Publikováno v: Soft Matter. 10:9313-9317

The solubility limits of cholesterol in small unilamellar vesicles made of POPS and POPC were probed using Small Angle Neutron Scattering (SANS) and coarse grained (CG) molecular dynamics (MD) simulations. SANS, being non-invasive, allowed the direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3705903f088a64d92888b52848863f
https://doi.org/10.1039/c4sm01219d

Temperature Behavior of Nanometer-Size Lipid Domains in DPPC:DLPC Model Membranes Studied by Small Angle Neutron Scattering

Autor: Paul Butler, Sumit Garg, Ursula Perez-Salas, Natalie Krzyzanowski, Lionel Porcar

Publikováno v: Biophysical Journal. 102(3)

Cellular membranes are no longer viewed as a heterogeneous mix of lipids and proteins, but rather as having distinct lipid domains which are key for many biological processes. Much work devoted to understanding the mechanisms that drives lateral orga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db15dc62d07f2af983a7d42022caffd

The Effect of Membrane-To-Domain Thickness Mismatch in Phase Separation Ternary Lipid Systems as a Function of Vesicle Size

Autor: Lionel Porcar, Natalie Krzyzanowski, Ursula Perez-Salas

Publikováno v: Biophysical Journal. 106:95a

Cellular membranes are no longer viewed as a homogeneous mix of lipids and proteins, but rather as having distinct lipid domains, so-called “rafts”, which are key for many biological processes. Much work devoted to understanding the actual mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685be9c442d69eddda34b3e3c1c18579
https://doi.org/10.1016/j.bpj.2013.11.598