Výsledky vyhledávání - "Natalie Kipling"

Akademický článek

Aggressive uveal melanoma displays a high degree of centrosome amplification, opening the door to therapeutic intervention

Autor: Dorota Sabat‐Pośpiech, Kim Fabian‐Kolpanowicz, Helen Kalirai, Natalie Kipling, Sarah E Coupland, Judy M Coulson, Andrew B Fielding

Publikováno v: The Journal of Pathology: Clinical Research, Vol 8, Iss 4, Pp 383-394 (2022)

Abstract Uveal melanoma (UM) is the most common intraocular cancer in adults. Whilst treatment of primary UM (PUM) is often successful, around 50% of patients develop metastatic disease with poor outcomes, linked to chromosome 3 loss (monosomy 3, M3)

Externí odkaz: https://doaj.org/article/e52134711fec4d00857b44a97422ee2d

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Transcriptome Profiling Reveals New Insights into the Immune Microenvironment and Upregulation of Novel Biomarkers in Metastatic Uveal Melanoma

Autor: Dorota Sabat-Pośpiech, Amelia Acha-Sagredo, Sarah E. Coupland, Helen Kalirai, Yamini Krishna, Natalie Kipling, Carlos R. Figueiredo, Kim Clarke

Publikováno v: Cancers
Volume 12
Issue 10
Cancers, Vol 12, Iss 2832, p 2832 (2020)

Metastatic uveal melanoma (mUM) to the liver is incurable. Transcriptome profiling of 40 formalin-fixed paraffin-embedded mUM liver resections and 6 control liver specimens was undertaken. mUMs were assessed for morphology, nuclear BAP1 (nBAP1) expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628f8cc4e655f71b890c533bf7e5cc2c
http://europepmc.org/articles/PMC7650807

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Targeted Next-Generation Sequencing of 117 Routine Clinical Samples Provides Further Insights into the Molecular Landscape of Uveal Melanoma

Autor: Sam Haldenby, Azzam Taktak, Xuan Liu, Sophie Thornton, Lisa Olohan, John Kenny, Helen Kalirai, Natalie Kipling, Heinrich Heimann, Rumana Hussain, J S Sibbring, Sarah E. Coupland, Christiane Hertz-Fowler

Publikováno v: CANCERS
Cancers
Volume 12
Issue 4
Cancers, Vol 12, Iss 1039, p 1039 (2020)

Uveal melanoma (UM) has well-characterised somatic copy number alterations (SCNA) in chromosomes 1, 3, 6 and 8, in addition to mutations in GNAQ, GNA11, CYSLTR2, PLCB4, BAP1, SF3B1 and EIF1AX, most being linked to metastatic-risk. To gain further ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d207af10968525c28d1f555168600a63
http://livrepository.liverpool.ac.uk/3085684/1/cancers-744518_revised_010420_SEC.pdf

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