Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Natalie K. Rynkiewicz"'
Autor:
Meredith J. Layton, Natalie K. Rynkiewicz, Ivan Ivetac, Kristy A. Horan, Christina A. Mitchell, Wayne A. Phillips
Publikováno v:
Bioscience Reports, Vol 34, Iss 2, p e00104 (2014)
Oncogenic mutations in PIK3CA lead to an increase in intrinsic phosphoinositide kinase activity, but it is thought that increased access of PI3Kα (phosphoinositide 3-kinase α) to its PM (plasma membrane) localized substrate is also required for inc
Externí odkaz:
https://doaj.org/article/13a6a58a586a41d09586fb2330ddd7f9
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
Autor:
Matthew J. Eramo, Helen E. Abud, Lisa M Ooms, Samuel J. Rodgers, Elizabeth V. Nguyen, Sabryn A. Hamila, Natalie K. Rynkiewicz, Absorn Sriratana, Georg Ramm, Genevieve Kerr, Catriona McLean, Viola Oorschot, Ralf B. Schittenhelm, Sherene Loi, Andrew M. Ellisdon, Rajendra Gurung, Christina Anne Mitchell, Clare G Fedele, Antonella Papa, Roger J. Daly, Franco Caramia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is also a reported oncogene in other cancers. How these opposing INPP4B roles relate to P
Autor:
Roger L. Williams, Sabine Suire, Oscar Vadas, David Oxley, Jonathan Clark, Karen E. Anderson, Natalie K. Rynkiewicz, Eleftherios Karanasios, Phillip T. Hawkins, Len R. Stephens, Daniel M. Collins
Publikováno v:
Sci Signal
The PI3Kγ isoform is activated by Gi-coupled GPCRs in myeloid cells, but the extent to which the two endogenous complexes of PI3Kγ, p101/p110γ and p84/p110γ, receive direct regulation through Gβγ or indirect regulation through RAS and the suffi
Autor:
Benjamin Grimshaw, Erin Spearing, Delphine Meynard, Luke Bayliss, Audrey Belot, Matthew Wake, Volker Germaschewski, Jemima Paterson, Jonathan Papworth, Igor Theurl, Emily Carter, Anais Palin, Amelie Largounez, Natalie K. Rynkiewicz, Verena Petzer, Alicia Poindron, Robyne Hudson
Publikováno v:
Blood. 134:3532-3532
Beta thalassemia is an inherited hemoglobinopathy caused by a genetic defect in beta-globin gene and characterised by ineffective erythropoiesis, iron overload, splenomegaly and anemia. Excessive EPO production, resulting from the anemia, has a suppr
Autor:
Graham G. Giles, Catriona McLean, Karen Chiam, Natalie K. Rynkiewicz, Lisa G. Horvath, James G. Kench, Lisa M Ooms, Clare G Fedele, Christina Anne Mitchell, Ruta Gupta
Publikováno v:
The Prostate. 75:92-102
BACKGROUND Phosphoinositide 3-kinase (PI3K)/Akt pathway is frequently activated in prostate carcinoma due to the loss of tumor suppressor PTEN, which leads to increased Akt activity. Expression of INPP4B, another negative regulator of the PI3K/Akt pa
Autor:
Mark A. Guthridge, Natalie K. Rynkiewicz, Nik Cummings, Sewa Rijal, Anthony T. Papenfuss, Andrew H. Wei, Tse-Chieh Teh, Julie McManus, Nhu-Y N Nguyen, Catriona McLean, Sharon Avery, Lisa M Ooms, Shaun Fleming, Christina Anne Mitchell
Publikováno v:
Blood. 125(18)
Phosphoinositide signaling regulates diverse cellular functions. Phosphoinositide-3 kinase (PI3K) generates PtdIns(3,4,5)P3 and PtdIns(3,4)P2, leading to the activation of proliferative and anti-apoptotic signaling pathways. Termination of phosphoino
Autor:
Natalie K, Rynkiewicz, Clare G, Fedele, Karen, Chiam, Ruta, Gupta, James G, Kench, Lisa M, Ooms, Catriona A, McLean, Graham G, Giles, Lisa G, Horvath, Christina A, Mitchell
Publikováno v:
The Prostate. 75(1)
Phosphoinositide 3-kinase (PI3K)/Akt pathway is frequently activated in prostate carcinoma due to the loss of tumor suppressor PTEN, which leads to increased Akt activity. Expression of INPP4B, another negative regulator of the PI3K/Akt pathway, is a
Autor:
Christina Anne Mitchell, Ivan Ivetac, Wayne A. Phillips, Natalie K. Rynkiewicz, Meredith J. Layton, Kristy A. Horan
Publikováno v:
Bioscience Reports
Bioscience Reports, Vol 34, Iss 2, p e00104 (2014)
Bioscience Reports, Vol 34, Iss 2, p e00104 (2014)
Oncogenic mutations in PIK3CA lead to an increase in intrinsic phosphoinositide kinase activity, but it is thought that increased access of PI3Kα (phosphoinositide 3-kinase α) to its PM (plasma membrane) localized substrate is also required for inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e57cf0b25e79fca314f084b77ffb8c
https://www.bib.irb.hr/1049295
https://www.bib.irb.hr/1049295
Publikováno v:
Advances in biological regulation. 52(1)
Autor:
Sharon Avery, Andrew H. Wei, Julie McManus, Christina Anne Mitchell, Natalie K. Rynkiewicz, Nik Cummings, Tse-Chieh Teh, Lisa M Ooms, Catriona McLean, Sewa Rijal, Nhu-Y Nugyen, Mark A. Guthridge
Publikováno v:
Cancer Research. 74:5283-5283
Acute myeloid leukaemia (AML) is an aggressive blood cancer that is usually fatal within weeks without effective therapy. Treatment currently involves standard chemotherapy agents such as cytarabine (Ara-C) and anthracyclines but these drugs fail to