Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Natalie J. Michael"'
Autor:
Vanessa R. Haynes, Natalie J. Michael, Marco van den Top, Fei-Yue Zhao, Russell D. Brown, David De Souza, Garron T. Dodd, David Spanswick, Matthew J. Watt
Publikováno v:
Molecular Metabolism, Vol 34, Iss , Pp 54-71 (2020)
Objectives: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and
Externí odkaz:
https://doaj.org/article/090fce1d57f8401b9e992de5fd12af30
Autor:
Zhenyan He, Yong Gao, Linh Lieu, Sadia Afrin, Jianhong Cao, Natalie J. Michael, Yanbin Dong, Jia Sun, Hongbo Guo, Kevin W. Williams
Publikováno v:
Molecular Metabolism, Vol 28, Iss , Pp 120-134 (2019)
Objective: The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide, stimulates insulin secretion and efficiently suppresses food intake to reduce body weight. As such, liraglutide is growing in popularity in the treatment of di
Externí odkaz:
https://doaj.org/article/3c40425daaa440eb92ca967c62533821
Autor:
Alexandre Caron, Ryan P. Reynolds, Carlos M. Castorena, Natalie J. Michael, Charlotte E. Lee, Syann Lee, Rebecca Berdeaux, Philipp E. Scherer, Joel K. Elmquist
Publikováno v:
Molecular Metabolism, Vol 27, Iss , Pp 11-21 (2019)
Objective: The sympathetic nervous system (SNS) is a key regulator of the metabolic and endocrine functions of adipose tissue. Increased SNS outflow promotes fat mobilization, stimulates non-shivering thermogenesis, promotes browning, and inhibits le
Externí odkaz:
https://doaj.org/article/6908bc3895a84129ab3937e7bf6ec68f
Autor:
Natalie J. Michael, Alexandre Caron, Charlotte E. Lee, Carlos M. Castorena, Syann Lee, Jeffrey M. Zigman, Kevin W. Williams, Joel K. Elmquist
Publikováno v:
Molecular Metabolism, Vol 35, Iss , Pp - (2020)
Objective: Histaminergic neurons of the tuberomammillary nucleus (TMN) are wake-promoting and contribute to the regulation of energy homeostasis. Evidence indicates that melanocortin 4 receptors (MC4R) are expressed within the TMN. However, whether t
Externí odkaz:
https://doaj.org/article/71a6e8f89c5d4d2f9dcde30b4adc9f45
Autor:
Garron T Dodd, Natalie J Michael, Robert S Lee-Young, Salvatore P Mangiafico, Jack T Pryor, Astrid C Munder, Stephanie E Simonds, Jens Claus Brüning, Zhong-Yin Zhang, Michael A Cowley, Sofianos Andrikopoulos, Tamas L Horvath, David Spanswick, Tony Tiganis
Publikováno v:
eLife, Vol 7 (2018)
Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes remain unclear. Here we define populations of POMC neurons in mice that are activated or inhib
Externí odkaz:
https://doaj.org/article/fab6ed8d6e114ea6b2ada91531963160
Autor:
Joel K. Elmquist, Amanda G. Arnold, Madison Granier, Charlotte E. Lee, Jiwon Lee, Teppei Fujikawa, Carlos M. Castorena, Natalie J. Michael, Arely Salazar Tinajero, Alexandre Caron, William L. Holland, Syann Lee, Chelsea Limboy, Newaz Ahmed, Chen Liu, Jay D. Horton, Simeng Wang
Publikováno v:
Am J Physiol Endocrinol Metab
Cannabinoid 1 receptor (CB1R) inverse agonists reduce body weight and improve several parameters of glucose homeostasis. However, these drugs have also been associated with deleterious side effects. CB1R expression is widespread in the brain and in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c15ff6cef6c5a843b1799c939704547
https://doi.org/10.1152/ajpendo.00044.2021
https://doi.org/10.1152/ajpendo.00044.2021
Autor:
Natalie J. Michael, Matthew J. Watt
Publikováno v:
Neuroscience. 451:164-173
Long chain fatty acids (LCFAs) have been suggested to influence the activity of hypothalamic neurons, however, limited studies have attempted to identify the neurochemical phenotype of these neurons. We aimed to determine if physiological levels of L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b220a3d1663c971093ea015058e6409d
https://doi.org/10.1016/j.neuroscience.2020.09.045
https://doi.org/10.1016/j.neuroscience.2020.09.045
Autor:
Marianne Gagnon, Stéphanie Fournier, François Marcouiller, Vincent Joseph, Natalie J. Michael, Richard Kinkead
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a5cf66b82cf9f17ecbfcc91fb7dee61
https://doi.org/10.1096/fasebj.2022.36.s1.r3722
https://doi.org/10.1096/fasebj.2022.36.s1.r3722
Autor:
Garron T. Dodd, David P De Souza, Russell D Brown, David Spanswick, Vanessa R. Haynes, Marco van den Top, Natalie J. Michael, Fei-Yue Zhao, Matthew J. Watt
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 34, Iss, Pp 54-71 (2020)
Molecular Metabolism, Vol 34, Iss, Pp 54-71 (2020)
Objectives Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3ae996a2befbf98fb187500b5a9cbd
https://doi.org/10.1016/j.molmet.2020.01.002
https://doi.org/10.1016/j.molmet.2020.01.002
Autor:
Joel K. Elmquist, Natalie J. Michael
Publikováno v:
J Clin Invest
The brain has evolved in an environment where food sources are scarce, and foraging for food is one of the major challenges for survival of the individual and species. Basic and clinical studies show that obesity or overnutrition leads to overwhelmin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad936a3be73cfa9b5473dc6e671bebb
https://doi.org/10.1172/jci140585
https://doi.org/10.1172/jci140585