Výsledky vyhledávání - "Natalie J. Hepburn"

The crystal structure of rat complement receptor 1-related protein Y (CrrY) helps dissecting decay-acceleration and fI-cofactor activities

Autor: Claire L. Harris, Susan M. Lea, B. Paul Morgan, K.J. Leath, Pietro Roversi, Natalie J. Hepburn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763bcfd3e512b3793c0fb9bf5d56c9a9
https://doi.org/10.1016/j.molimm.2008.08.006

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Suppression of complement activation by recombinant Crry inhibits experimental autoimmune anterior uveitis (EAAU)

Autor: B. Paul Morgan, Nalini S. Bora, Purushottam Jha, Claire L. Harris, Balasubramanian Manickam, Natalie J. Hepburn, Puran S. Bora

Publikováno v: Molecular Immunology. 48:231-239

This study was initiated to explore the effect of recombinant rat Crry linked to the Fc portion of rat IgG2a (Crry-Ig) on the induction of experimental autoimmune anterior uveitis (EAAU) and on established disease. EAAU was induced in Lewis rats by i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b29a7aa56ef3947572254c09da959ce
https://doi.org/10.1016/j.molimm.2010.08.006

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Prevention of experimental autoimmune myasthenia gravis by rat Crry-Ig: A model agent for long-term complement inhibition in vivo

Autor: Jayne L. Chamberlain-Banoub, Bryan Paul Morgan, Natalie J. Hepburn, Anwen Sian Williams, Claire L. Harris

Publikováno v: Molecular Immunology

Despite its vital role in innate immunity, complement is involved in a number of inflammatory pathologies and has therefore become a therapeutic target. Most agents generated for anti-complement therapy have short half-lives in plasma, or have been o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63c574336baab19a4a86867dcbe5c82
https://doi.org/10.1016/j.molimm.2007.06.144

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Zymosan, but not lipopolysaccharide, triggers severe and progressive peritoneal injury accompanied by complement activation in a rat peritonitis model

Autor: Tomohiro Mizuno, Yukihiro Noda, Yasuhiko Ito, B. Paul Morgan, Masashi Mizuno, Natalie J. Hepburn, Yukio Yuzawa, Seiichi Matsuo, Claire L. Harris

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 183(2)

Fungal peritonitis is an important complication in peritoneal dialysis patients; either continuous or recurrent peritonitis may enhance peritoneal damage. Even when the peritoneal dialysis catheter is removed in patients with fungal peritonitis, peri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae8ee141fdf49f6e88a6163683b239d
https://pubmed.ncbi.nlm.nih.gov/19553534

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Complement, roles in renal disease and modulation for therapy

Autor: Claire L. Harris, Marieta M. Ruseva, Natalie J. Hepburn, Bryan Paul Morgan

Publikováno v: Europe PubMed Central

The complement system, an essential part of the innate immune system, defends the host against invading pathogens, prevents immune complex disease and aids the acquired immune response. Under normal conditions the host is protected from complement at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0433c21a9914579bad40329ef0f469c7
https://pubmed.ncbi.nlm.nih.gov/19000536

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