Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Natalie J. Davidson"'
Autor:
Natalie J. Davidson, Satish Menon, Michael W. Leach, Robin Lesley, Madeline M. Fort, Frank Brombacher, Donna Rennick
Publikováno v:
The Journal of Immunology. 166:2793-2800
IL-4 is associated with Th2-type immune responses and can either inhibit or, in some cases, promote Th1-type responses. We tested the effect of IL-4 treatment on the development of inflammation in the CD4+CD45RBhigh T cell transfer model of colitis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5c1aa458fd8d0ae674d40e8f874851
https://doi.org/10.4049/jimmunol.166.4.2793
https://doi.org/10.4049/jimmunol.166.4.2793
Publikováno v:
International Reviews of Immunology. 19:91-121
IL-10-deficient (IL-10-/-) mice, generated by a gene-targeted mutation, develop abnormal immune responses as a result of uncontrolled interactions between antigen presenting cells and lymphocytes. The studies reviewed herein have focused on the enter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcde0aa42eb0dcd32042038095216f8c
https://doi.org/10.3109/08830180009048392
https://doi.org/10.3109/08830180009048392
Autor:
Natalie J. Davidson, Susan A. Hudak, Robin E. Lesley, Satish Menon, Michael W. Leach, Donna M. Rennick
Publikováno v:
The Journal of Immunology. 161:3143-3149
IL-10-deficient (IL-10−/−) mice develop chronic enterocolitis mediated by CD4+ Th1 cells producing IFN-γ. Because IL-12 can promote Th1 development and IFN-γ production, the ability of neutralizing anti-IL-12 mAb to modulate colitis in IL-10−
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f528fd1b64ad5646f1e0aaeae841b537
https://doi.org/10.4049/jimmunol.161.6.3143
https://doi.org/10.4049/jimmunol.161.6.3143
Autor:
Natalie J Davidson
Publikováno v:
Expert Opinion on Investigational Drugs. 7:1115-1120
The outcome of inflammatory diseases is likely to be dependent upon the relative balance of pro- versus anti-inflammatory cytokines. Control of this balance through the use of anti-cytokine monoclonal antibodies (mAbs) promises to be an effective mea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62ad308bf7e4f04e75adad1a6da77dc
https://doi.org/10.1517/13543784.7.7.1115
https://doi.org/10.1517/13543784.7.7.1115
T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice
Autor:
Daniel J. Berg, Werner Müller, Donna M. Rennick, Luann Thompson-Snipes, Madeline M. Fort, Ralf Kühn, Michael W. Leach, Natalie J. Davidson
Publikováno v:
The Journal of Experimental Medicine
Mice rendered deficient in the production of interleukin 10 (IL-10-/-) develop a chronic inflammatory bowel disease (IBD) that predominates in the colon and shares histopathological features with human IBD. Our aim was to identify which cell type(s)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39fe46a4ebaffca4f2df39f138685c4
https://doi.org/10.1084/jem.184.1.241
https://doi.org/10.1084/jem.184.1.241
Publikováno v:
Clinical Immunology and Immunopathology. 76:S174-S178
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c6d81e9beb996498a73b3d57fc9935
https://doi.org/10.1016/s0090-1229(95)90144-2
https://doi.org/10.1016/s0090-1229(95)90144-2
Autor:
Daniel J. Berg, Ralf Kühn, Werner Müller, Michael W. Leach, Klaus Rajewsky, Natalie J. Davidson, Donna M. Rennick
Publikováno v:
The Journal of Experimental Medicine
We have examined the role of endogenously produced interleukin (IL) 4 and IL-10 in the regulation of inflammatory and immune reactions in the skin. In these experiments, irritant and contact hypersensitivity (CH) responses were elicited in mice with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8e2caf3242db1e53e470c2e49c7984
https://doi.org/10.1084/jem.182.1.99
https://doi.org/10.1084/jem.182.1.99
Autor:
Natalie J. Davidson, Richard L. Boyd
Publikováno v:
Developmental Immunology
The chicken thymic microenvironment, as it developed in an embryonic thymus organ culture system, was phenotypically mapped using a panel of mAb defining both epithelial and nonepithelial stromal cell antigens. We have previously reported that thymoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e41deff84761b34ee90c5992e777dd
https://doi.org/10.1155/1993/51718
https://doi.org/10.1155/1993/51718
Publikováno v:
European Journal of Immunology. 22:1429-1435
Thymocyte development was monitored in an embryonic thymus organ culture system to establish a model in the chicken in which the functional nature of the thymic microenvironment could be assessed. Thymus lobes were removed from 10-day-old embryos and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cc31462b1716397f09218ddd8abc10
https://doi.org/10.1002/eji.1830220615
https://doi.org/10.1002/eji.1830220615
Publikováno v:
Toxicologic pathology. 27(1)
Inflammatory bowel disease (IBD) is a generic term typically used to describe a group of idiopathic inflammatory intestinal conditions in humans that are generally divided into Crohn's disease and ulcerative colitis. Although the etiology of these di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7f1f5a9f7b53364fc9a009ba6850cb
https://pubmed.ncbi.nlm.nih.gov/10367687
https://pubmed.ncbi.nlm.nih.gov/10367687