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pro vyhledávání: '"Natalie J. Briones"'
In vivo interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype.
Autor:
Daniel R Ambruso, Natalie J Briones, Angelina F Baroffio, John R Murphy, Alexander D Tran, Katherine Gowan, Bridget Sanford, Michael Ellison, Kenneth L Jones
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
The cytokine Interferon-γ (IFN-γ) exerts powerful immunoregulatory effects on the adaptive immune system and also enhances functions of the neutrophil (PMN). The clinical use of IFN-γ has been driven by the finding that its administration to patie
Externí odkaz:
https://doaj.org/article/5560076a792640a2978e1586fa78271e
Autor:
John Murphy, Daniel R. Ambruso, Angelina Baroffio, Alexander D. Tran, Michael Ellison, Julie A. Reisz, Christopher M. McKinney, Natalie J. Briones, Angelo D'Alessandro
Publikováno v:
Blood Adv
Severe congenital neutropenia type 4 (SCN-4) is an autosomal recessive condition in which mutations in the G6PC3 gene encoding for the catalytic 3 subunit of glucose-6-phosphatase-β result in neutropenia, neutrophil dysfunction, and other syndromic