Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Natalie J Griffiths"'
Autor:
Darryl J Hill, Natalie J Griffiths, Elena Borodina, Clio A Andreae, Richard B Sessions, Mumtaz Virji
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0124133 (2015)
The human pathogen Neisseria meningitides (Nm) attains serum resistance via a number of mechanisms, one of which involves binding to the host complement regulator protein vitronectin. We have shown previously that the Meningococcal surface fibril (Ms
Externí odkaz:
https://doaj.org/article/b5a49fde3607460a878b1c17b8cfc3dd
Publikováno v:
PLoS Pathogens, Vol 6, Iss 5, p e1000911 (2010)
The host vasculature is believed to constitute the principal route of dissemination of Neisseria meningitidis (Nm) throughout the body, resulting in septicaemia and meningitis in susceptible humans. In vitro, the Nm outer membrane protein Opc can enh
Externí odkaz:
https://doaj.org/article/59d45b8ca4a842baa60117b4dcab7523
Autor:
Natalie J. Griffiths, Claudia Sa E Cunha, Isabel Murillo, Abdel-Rahman Youssef, Elena Borodina, Darryl J. Hill, Mumtaz Virji
Publikováno v:
VacciMonitor, Vol 18, Iss 2, Pp 88-90 (2009)
Neisseria meningitidis outer membrane (OM) adhesins, Opa and Opc are known to exert significant influence on bacterial adhesion and invasion properties. They are also likely to affect the dynamics of cellular barrier penetration as they target human
Externí odkaz:
https://doaj.org/article/5f9922fba47045a3b3a9698a25f5f3aa
Autor:
Darryl J. Hill, Mumtaz Virji, Nathalie Devos, Natalie J. Griffiths, Jan Poolman, Elena Borodina, Christiane Feron, Richard B. Sessions
Publikováno v:
Molecular Microbiology. 82:1129-1149
Complement evasion is an important survival strategy of Neisseria meningitidis (Nm) during colonization and infection. Previously, we have shown that Nm Opc binds to serum vitronectin to inhibit complement-mediated killing. In this study, we demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd182048982df12a0cd38753ee9d9f6c
https://doi.org/10.1111/j.1365-2958.2011.07876.x
https://doi.org/10.1111/j.1365-2958.2011.07876.x
Publikováno v:
Clinical Science (London, England : 1979)
The human species is the only natural host of Neisseria meningitidis, an important cause of bacterial meningitis globally, and, despite its association with devastating diseases, N. meningitidis is a commensal organism found frequently in the respira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02caaf78eba818ca40f090a4f2b4a13
https://doi.org/10.1042/cs20090513
https://doi.org/10.1042/cs20090513
Autor:
Mumtaz Virji, Sandrine Bourdoulous, Darryl J. Hill, Etienne Carbonnelle, Natalie J. Griffiths, Xavier Nassif, Isabel Murillo, Philippe Morand
Publikováno v:
Vaccine. 27:B78-B89
Neisseria meningitidis interacts with host tissues through hierarchical, concerted and co-ordinated actions of a number of adhesins; many of which undergo antigenic and phase variation, a strategy that helps immune evasion. Three major structures, pi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ef0f450b8b272489773308b1458151
https://doi.org/10.1016/j.vaccine.2009.04.069
https://doi.org/10.1016/j.vaccine.2009.04.069
Publikováno v:
Cellular Microbiology
Neisseria meningitidis Opc protein is an effective invasin for human endothelial cells. We have investigated novel human endothelial receptors targeted by Opc and observed that Opc-expressing bacteria interacted with a 100 kDa protein in whole-cell l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e93ec955f1e21d16e698f5373d4071
https://doi.org/10.1111/j.1462-5822.2008.01262.x
https://doi.org/10.1111/j.1462-5822.2008.01262.x
Publikováno v:
Cellular Microbiology. 9:2968-2983
Temporal relationship between viral and bacterial infections has been observed, and may arise via the action of virus-induced inflammatory cytokines. These, by upregulating epithelial receptors targeted by bacteria, may encourage greater bacterial in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9a2905cbd0bd57d594a679a3db55803
https://doi.org/10.1111/j.1462-5822.2007.01038.x
https://doi.org/10.1111/j.1462-5822.2007.01038.x
Publikováno v:
Cellular Microbiology. 9:154-168
Summary Neisseria meningitidis (Nm) is a human specific opportunistic pathogen that occasionally penetrates mucosal barriers via the action of adhesins and invasins and evades host immune mechanisms during further dissemination via capsule expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cda8736314bfdb0720755d8ce124e53
https://doi.org/10.1111/j.1462-5822.2006.00775.x
https://doi.org/10.1111/j.1462-5822.2006.00775.x
Autor:
Zineb Benmechernene, Mumtaz Virji, Simon Bailey, Christos Tzitzilonis, Jeremy Moore, Natalie J. Griffiths, Jeremy P. Derrick
Publikováno v:
Journal of Biological Chemistry. 280:31489-31497
The adhesion of the pathogen Neisseria meningitidis to host cell surface proteoglycan, mediated by the integral outer membrane proteins OpcA and Opa, plays an important part in the processes of colonization and invasion by the bacterium. The precise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a58dca8aa14cb61525b3031b60d456
https://doi.org/10.1074/jbc.m506354200
https://doi.org/10.1074/jbc.m506354200