Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Natalie J, Spillman"'
Autor:
Janette Reader, Mariëtte E. van der Watt, Dale Taylor, Claire Le Manach, Nimisha Mittal, Sabine Ottilie, Anjo Theron, Phanankosi Moyo, Erica Erlank, Luisa Nardini, Nelius Venter, Sonja Lauterbach, Belinda Bezuidenhout, Andre Horatscheck, Ashleigh van Heerden, Natalie J. Spillman, Anne N. Cowell, Jessica Connacher, Daniel Opperman, Lindsey M. Orchard, Manuel Llinás, Eva S. Istvan, Daniel E. Goldberg, Grant A. Boyle, David Calvo, Dalu Mancama, Theresa L. Coetzer, Elizabeth A. Winzeler, James Duffy, Lizette L. Koekemoer, Gregory Basarab, Kelly Chibale, Lyn-Marié Birkholtz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Here, Reader et al. screen the Medicines for Malaria Venture Pandemic Response Box in parallel against Plasmodiumasexual and liver stage parasites, stage IV/V gametocytes, gametes, oocysts and as endectocides. They identify two potent transmission-bl
Externí odkaz:
https://doaj.org/article/469ad5b32c23403795a07ad1d5fdbabe
Publikováno v:
eLife, Vol 9 (2020)
The antibiotic actinonin kills malaria parasites (Plasmodium falciparum) by interfering with apicoplast function. Early evidence suggested that actinonin inhibited prokaryote-like post-translational modification in the apicoplast; mimicking its activ
Externí odkaz:
https://doaj.org/article/d24db42376c24f489aa9dfd3a0be2dc2
Autor:
Jessica L. Bridgford, Stanley C. Xie, Simon A. Cobbold, Charisse Flerida A. Pasaje, Susann Herrmann, Tuo Yang, David L. Gillett, Lawrence R. Dick, Stuart A. Ralph, Con Dogovski, Natalie J. Spillman, Leann Tilley
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Artemisinin (ART) is a widely used antimalarial drug, but its mechanism of action is poorly understood. Here, Bridgford et al. show that ART kills parasites by a two-pronged mechanism, causing protein damage and compromising proteasome function, and
Externí odkaz:
https://doaj.org/article/65e9ecff6a5e4bf9bde0b3289d249518
Autor:
Kit Kennedy, Simon A Cobbold, Eric Hanssen, Jakob Birnbaum, Natalie J Spillman, Emma McHugh, Hannah Brown, Leann Tilley, Tobias Spielmann, Malcolm J McConville, Stuart A Ralph
Publikováno v:
PLoS Biology, Vol 17, Iss 7, p e3000376 (2019)
Apicomplexan parasites possess a plastid organelle called the apicoplast. Inhibitors that selectively target apicoplast housekeeping functions, including DNA replication and protein translation, are lethal for the parasite, and several (doxycycline,
Externí odkaz:
https://doaj.org/article/19120ff55fa54ec1bc71582404843ed8
Publikováno v:
mBio, Vol 8, Iss 2 (2017)
Externí odkaz:
https://doaj.org/article/8309c65bfe6c43f2ab908efcd0ef437e
Autor:
Fabio T. M. Costa, Júlio César Borges, Elizabeth Bilsland, Antonio P. Camargo, Carolina Horta Andrade, Diana Fontinha, Letícia Tiburcio Ferreira, Natalie J. Spillman, Miguel Prudêncio, Per Sunnerhagen, Djane Clarys Baia da Silva, Stefanie C. P. Lopes, Ana Carolina A. V. Kayano, Pedro Cravo, Bruno J. Neves, Marcelo Falsarella Carazzolle, Ludimila Dias Almeida, Kaira C. P. Tomaz, Luis Carlos Salazar Alvarez, Marcus V. G. Lacerda, Leann Tilley, Adrielle Ayumi de Vasconcelos, Daniel Y. Bargieri, Noeli Soares Melo da Silva, Tatyana Almeida Tavella, Gustavo Capatti Cassiano
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ACS Infectious Diseases
Universidade de São Paulo (USP)
instacron:USP
ACS Infectious Diseases
Antimalarial drugs with novel modes of action and wide therapeutic potential are needed to pave the way for malaria eradication. Violacein is a natural compound known for its biological activity against cancer cells and several pathogens, including t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950b53ad06dafb8e88ef50f1b34dfcc8
https://doi.org/10.1021/acsinfecdis.0c00454
https://doi.org/10.1021/acsinfecdis.0c00454
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
ABSTRACT Erythrocytes are reservoirs of important epoxide-containing lipid signaling molecules, including epoxyeicosatrienoic acids (EETs). EETs function as vasodilators and anti-inflammatory modulators in the bloodstream. Bioactive EETs are hydrolyz
Externí odkaz:
https://doaj.org/article/3e606cfd06664d5bacbd165b2cacc9b5
Autor:
Andrew Leis, Michael D. W. Griffin, Tuo Yang, David L. Gillett, Lawrence R. Dick, Michael J. Kuiper, Natalie J. Spillman, Christopher Tsu, Wilson Wong, Michael W. Parker, Craig J. Morton, Stanley C. Xie, Eric Hanssen, Riley D. Metcalfe, Leann Tilley
Publikováno v:
Nature Microbiology. 4:1990-2000
The activity of the proteasome 20S catalytic core is regulated by protein complexes that bind to one or both ends. The PA28 regulator stimulates 20S proteasome peptidase activity in vitro, but its role in vivo remains unclear. Here, we show that gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9535c01f9c05493f2591dff6108398
https://doi.org/10.1038/s41564-019-0524-4
https://doi.org/10.1038/s41564-019-0524-4
Autor:
Sabine Ottilie, Dale Taylor, Mariëtte van der Watt, Phanankosi Moyo, Lizette L. Koekemoer, Claire Le Manach, Daniel Opperman, James Duffy, Erica Erlank, Kelly Chibale, Sonja B Lauterbach, Lyn-Marie Birkholtz, Daniel E. Goldberg, Nimisha Mittal, Jessica I. Connacher, Lindsey M. Orchard, Ashleigh van Heerden, Natalie J. Spillman, Theresa L. Coetzer, Gregory S. Basarab, André Horatscheck, David Calvo, Elizabeth A. Winzeler, Anjo Theron, Janette Reader, Dalu Mancama, Nelius Venter, Grant A. Boyle, Eva S. Istvan, Manuel Llinás, Belinda C. Bezuidenhout, Luisa Nardini, Anne N. Cowell
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium. Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic Response Box against Plasmodiu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65542ff95a46fa520faa2ebd28c4b18c
https://doi.org/10.1038/s41467-020-20629-8
https://doi.org/10.1038/s41467-020-20629-8
Publikováno v:
eLife, Vol 9 (2020)
The antibiotic actinonin kills malaria parasites (Plasmodium falciparum) by interfering with apicoplast function. Early evidence suggested that actinonin inhibited prokaryote-like post-translational modification in the apicoplast; mimicking its activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6430ddd27cdf683a81523deaad481c72
https://doi.org/10.7554/elife.58629
https://doi.org/10.7554/elife.58629